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FMNL2 encodes a formin-related protein. Additionally we are shipping FMNL2 Antibodies (26) and FMNL2 Kits (4) and many more products for this protein.
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force generation in lamellipodia strongly depends on FMNL (show FMNL1 Proteins) formin (show FMN1 Proteins) activity.
FMNL1 (show FMNL1 Proteins) and FMNL2 are required non-redundantly in the repair of damaged myofibrils.
FMNL2 is a novel elongation factor of actin filaments that constitutes the first Cdc42 effector promoting cell migration and actin polymerization at the tips of lamellipodia.
mDia1-FH2 has an effect on the conformation of actin filaments
FMNL2 knockout cells were characterized by impaired filopodia formation similar to depletion of the Rho GTPase (show RACGAP1 Proteins) Cdc42 (show CDC42 Proteins).
Data demonstrate that the FMNL2/COMMD10/p65 NF kappaB (show NFkBP65 Proteins) axis acts as a critical regulator in the maintenance of metastatic phenotypes in colorectal cancer.
Our data proved that RMRP (show NME1 Proteins) acted as an oncogene (show RAB1A Proteins) LncRNA to promote the expression of KRAS, FMNL2 and SOX9 (show SOX9 Proteins) by inhibiting miR (show MLXIP Proteins)-206 expression in lung cancer. These data suggested that RMRP (show NME1 Proteins) might serve as a therapeutic target in lung adenocarcinoma
FMNL2 is likely to be generally required in melanoma cells for invasion.
miR (show MLXIP Proteins)-206 functioned as a tumor suppressor in the progression of colorectal cancer(CRC (show CALR Proteins)) by targeting FMNL2 and c-MET. Restoration of miR (show MLXIP Proteins)-206 expression may represent a promising therapeutic approach for targeting malignant CRC (show CALR Proteins).
Capping protein and FMNL2 functionally coregulate filament barbed-end assembly.
The two interacting FMNL-Cdc42 heterodimers expose six membrane interaction motifs on a convex protein surface, the assembly of which may facilitate actin filament elongation at the leading edge of lamellipodia and filopodia.
These data establish a role for FMNL2 in the regulation of beta1-integrin and provide a mechanistic understanding of the function of FMNL2 in cancer invasiveness.
MiR-34a was down-regulated in colorectal cancer cells and inversely correlated with FMNL2 and E2F5 expressions. Our study suggests that miR-34a is an important tumor suppressor of CRC progression by targeting FMNL2 and E2F5.
Rac1-induced actin assembly and subsequent AJ formation critically depends on FMNL2.
This gene encodes a formin-related protein. Formin-related proteins have been implicated in morphogenesis, cytokinesis, and cell polarity. Alternatively spliced transcript variants encoding different isoforms have been described but their full-length nature has yet to be determined.
formin-like domain containing protein MAN
, formin-like protein 2
, protein Man
, formin homology 2 domain containing 2
, formin homology 2 domain-containing protein 2
, formin-like 2