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FPR1 encodes a G protein-coupled receptor of mammalian phagocytic cells that is a member of the G-protein coupled receptor 1 family. Additionally we are shipping FPR1 Antibodies (119) and FPR1 Proteins (5) and many more products for this protein.
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To develop enzyme-resistant analogues, we applied here the Retro-Inverso (RI) approach, whereby the topology of the side chains is maintained by inverting the sequence of the peptide and the chirality of all residues. Molecular dynamics suggests that peptide RI-3 adopts the turn structure typical of uPAR (show PLAUR ELISA Kits)-FPR1 antagonists
Authors found that the co-expression of uPAR (show PLAUR ELISA Kits) and FPR1 confers to A375 and M14 melanoma cells a clear-cut capability to move towards chemotactic gradients, to cross extracellular matrix and endothelial monolayers. FPR1 activity is required, as cell migration and invasion were abrogated by receptor desensitization.
Taken together, our results suggest that intracellular FPR in naive CD4 (show CD4 ELISA Kits) T cells and surface FPRs in activated CD4 (show CD4 ELISA Kits) T cells might regulate immune responses by regulating CD4 (show CD4 ELISA Kits) T cell activity.
the FPR1 downstream signaling pathways were competitively inhibited by HCH6-1. Furthermore, HCH6-1 prevented pulmonary neutrophil infiltration and edema along with alveolar damage in LPS-induced ALI in mice. Our findings suggest that HCH6-1, a FPR1 antagonist, may have potential as a new therapeutic agent for treating FPR1-involved inflammatory lung diseases
The data demonstrate that FPR1 is involved in neuroblastoma development and could represent a therapy option for the treatment of neuroblastoma.
FAM3D plays a role in gastrointestinal homeostasis and inflammation through its receptors FPR1 and FPR2 (show FPR2 ELISA Kits).
Formylated MHC class Ib (show HLAF ELISA Kits) binding peptides activate both human and mouse neutrophils primarily through FPR1.
The inhibitory function of oxidant sensing by TRPM2 (show CLU ELISA Kits) requires the oxidation of Cys549, which then induces TRMP2 binding to formyl peptide receptor 1 (FPR1) and subsequent FPR1 internalization and signaling inhibition
FPR1 expression is significantly upregulated in human masticatory mucosa during wound healing
FAM19A4 (show FAM19A4 ELISA Kits) is a novel ligand of formyl peptide receptor 1.
Study showed significantly increased expression of FPR1 and FPR2 (show FPR2 ELISA Kits), during differentiation of neural stem cells (NSCs). The activation of FPRs promotes NSCs to differentiate into neurons with more primary neurites and branch points and longer neurites per cell. Meanwhile, this activation also inhibits the differentiation of NSCs into astrocytes.
FPR1-deficient mice showed a slight but significant decrease of demyelination in the corpus callosum and reduced glial cell activation.
the FPR1 downstream signaling pathways were competitively inhibited by HCH6-1. Furthermore, HCH6-1 prevented pulmonary neutrophil infiltration and edema along with alveolar damage in LPS (show TLR4 ELISA Kits)-induced ALI in mice. Our findings suggest that HCH6-1, a FPR1 antagonist, may have potential as a new therapeutic agent for treating FPR1-involved inflammatory lung diseases
Intravital TPLSM revealed that formyl-peptide-FPR1 signaling is responsible for regulating neutrophil chemotaxis to allow migration into the necrotic area in hepatic ischemia-reperfusion injury
Formylated MHC class Ib binding peptides activate both human and mouse neutrophils primarily through FPR1.
Blocking of FPR1 completely abrogated the fMet-Leu-Phe-, gliadin- and synthetic peptide-induced migration.
these results highlight the importance of FPR1 in chemotherapy-induced anticancer immune responses.
Ovalbumininduced airway inflammation is mediated by upregulation of the TLR2/MyD88 (show MYD88 ELISA Kits)/NFkappaB signaling pathway and inhibition of LXA4R.
Deficiency of formyl peptide receptor 1 is associated with increased inflammation and enhanced liver injury after LPS-stimulation
This gene encodes a G protein-coupled receptor of mammalian phagocytic cells that is a member of the G-protein coupled receptor 1 family. The protein mediates the response of phagocytic cells to invasion of the host by microorganisms and is important in host defense and inflammation.
N-formylpeptide chemoattractant receptor
, fMLP receptor
, fMet-Leu-Phe receptor
, N-formyl peptide receptor
, lipoxin A4 receptor