anti-Fragile X Mental Retardation, Autosomal Homolog 1 (FXR1) Antibodies

The protein encoded by FXR1 is an RNA binding protein that interacts with the functionally-similar proteins FMR1 and FXR2. Additionally we are shipping FXR1 Proteins (4) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
FXR1 8087 P51114
FXR1 361927 Q5XI81
FXR1 14359 Q61584
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Top anti-FXR1 Antibodies at antibodies-online.com

Showing 10 out of 101 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-FXR1 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Goat Un-conjugated ELISA, FACS, IF, WB ABIN185683 (0.2µg/ml) staining of NIH/3T3 cell lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 6 to 7 Days
$429.84
Details
Dog Goat Un-conjugated WB   0.1 mg Log in to see Available
$462.00
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), IP, WB Western Blot: FXR1 Antibody [NBP1-33719] - Sample (30 ug of whole cell lysate) A: Hep G2 7. 5% SDS PAGE; antibody diluted at 1:1000. Immunocytochemistry/Immunofluorescence: FXR1 Antibody [NBP1-33719] - Analysis of methanol-fixed HeLa, using antibody at 1:100 dilution. 0.1 mL Log in to see 8 to 11 Days
$516.98
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), SimWes, WB Western Blot: FXR1 Antibody [NBP1-89546] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11.Lane 2: Human cell line RT-4.Lane 3: Human cell line U-251MG sp.Lane 4: Human plasma (IgG/HSA depleted).Lane 5: Human liver tissue.Lane 6: Human tonsil tissue Immunocytochemistry/Immunofluorescence: FXR1 Antibody [NBP1-89546] - Staining of human cell line A-431 shows positivity in cytoplasm. 0.1 mL Log in to see 10 to 13 Days
$494.38
Details
Human Mouse Un-conjugated ELISA, IHC, WB Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.63 KDa) . Dilution: 1:500~1000 100 μg Log in to see 8 to 11 Days
$527.50
Details
Human Rabbit Un-conjugated IP, WB Immunoprecipitation: FXR1 Antibody [NBP2-22246] - Whole cell lysate (1 mg for IP; 20% of IP loaded) from 293T cells. Antibodies: NBP2-22246 used for IP at 6 ug/mg lysate. FXR1 was also immunoprecipitated by rabbit anti-FXR1 antibody. For blotting immunoprecipitated FXR1, NBP2-22246 was used at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 10 seconds. Western Blot: FXR1 Antibody [NBP2-22246] - Whole cell lysate from mouse NIH3T3 (15 and 50 ug) cells. NBP2-22246 used for WB at 0.4 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes. 100 μL Log in to see 7 to 9 Days
$559.35
Details
Bat Rabbit Un-conjugated WB 50 μg Log in to see 11 to 14 Days
$551.83
Details
Bat Goat Un-conjugated ELISA, WB 100 μg Log in to see 11 to 14 Days
$610.50
Details
Mouse Rabbit Un-conjugated WB FXR1 Antibody (N-term) (ABIN1881357) western blot analysis in mouse liver tissue lysates (35 µg/lane). This demonstrates the FXR1 antibody detected the FXR1 protein (arrow). 400 μL Log in to see 10 to 11 Days
$385.00
Details

Top referenced anti-FXR1 Antibodies

  1. Mouse (Murine) Polyclonal FXR1 Primary Antibody for WB - ABIN1881357 : Coffee, Tessier, Woodruff, Broadie: Fragile X mental retardation protein has a unique, evolutionarily conserved neuronal function not shared with FXR1P or FXR2P. in Disease models & mechanisms 2010 (PubMed)
    Show all 5 Pubmed References

  2. Dog (Canine) Polyclonal FXR1 Primary Antibody for ELISA, WB - ABIN547728 : Coon, Matsunami, Stevens, Miller, Pingree, Camp, Thomas, Krasny, Lainhart, Leppert, McMahon: Evidence for linkage on chromosome 3q25-27 in a large autism extended pedigree. in Human heredity 2006 (PubMed)

  3. Human Polyclonal FXR1 Primary Antibody for ICC, IF - ABIN4312875 : Fischer-Kešo, Breuninger, Hofmann, Henn, Röhrig, Ströbel, Stoecklin, Hofmann: Plakophilins 1 and 3 bind to FXR1 and thereby influence the mRNA stability of desmosomal proteins. in Molecular and cellular biology 2014 (PubMed)

  4. Human Polyclonal FXR1 Primary Antibody for IF (p), IHC (p) - ABIN710891 : Zhao, Xu, Yuan, Jiang, Zhou, Li, Yin, Zhou, Zhang, Wang: 8-Methoxypsoralen disrupts MDR3-mediated phospholipids efflux and bile acid homeostasis and its relevance to hepatotoxicity. in Toxicology 2017 (PubMed)

More Antibodies against FXR1 Interaction Partners

Human Fragile X Mental Retardation, Autosomal Homolog 1 (FXR1) interaction partners

  1. in head and neck squamous cell carcinoma, fragile X mental retardation syndrome related protein 1 (Fxr1) overexpression correlates with reduced F-box protein 4 (Fbxo4) levels.

  2. In the Title.

  3. Inhibition of the remaining family member FXR1 selectively blocks cell proliferation in human cancer cells containing homozygous deletion of both TP53 and FXR2 in a collateral lethality manner.

  4. Our findings support our a priori hypothesis of a possible interaction between GSK3B (rs12630592 T allele) and FXR1 (rs496250 A allele) in mood disorder patients.

  5. human microbiota was able to reduce the levels of tauro-beta-muricholic acid and induce expression of FXR target genes Fgf15 and Shp in ileum after long-term colonization. We show that a human microbiota can change BA composition and induce FXR signaling in colonized mice, but the levels of secondary BAs produced are lower than in mice colonized with a mouse microbiota

  6. These data reveal a new role of FXR1 in controlling induction of monocyte migration.

  7. FXR1 binds and destabilizes p21 mRNA, binds and stabilizes TERC RNA and suppresses the cellular senescence in oral cancer cells.

  8. FXR1P interacts with CMAS, and that FXR1P may enhance the activation of sialic acid via interaction with CMAS, and increase GM1 levels to affect the development of the nervous system, thus providing evidence for further research into the pathogenesis of FXS.

  9. P97 interacts with 3' UTR-binding FXR1a-associated microRNPs and with PARN, which binds mRNA 5' caps, forming a specialized complex to translate recruited mRNAs in these altered canonical translation conditions.

  10. An accumulation of 8 SNPs in the fragile gene family (FMR1, FXR1 and FXR2)were found associated with autistic traits in a sample of male patients.

  11. FXR1P is a GSK3beta substrate with a role in regulating mood and emotion processing

  12. The mechanisms by which FXR1 executes its regulatory function by forming a novel complex with two other oncogenes, protein kinase C, iota and epithelial cell transforming 2, located in the same amplicon via distinct binding mechanisms, were identified.

  13. binding of PKP1/3 to FXR1 was RNA independent, and both PKP3 and FXR1 stabilized PKP2 mRNA.

  14. Deregulation of Fragile X-related protein 1 by the lipodystrophic lamin A p.R482W mutation elicits a myogenic gene expression program in preadipocytes.

  15. findings showed that FXR1P interacts with BTF in vivo and proved that FXR1P and BTF can co-localize mainly in the cytoplasm around the nucleus

  16. FXR1 and UPF1 may have a functional role in prostate cancer progression and metastasis.

  17. Our study describes a novel role of FXR1P that has crucial implications for the understanding of its role during myogenesis and muscle development

  18. Data show that the nuclear localization signals of the FXR1 and FXR2 comprise tandem Tudor domain architectures.

  19. These results indicate that FMR1 gene function is evolutionarily conserved in neural mechanisms and cannot be compensated by either FXR1 or FXR2, but that all three proteins can substitute for each other in non-neuronal requirements.

  20. Fxr1p shows a more tissue-specific expression particularly during late embryonic development.

Mouse (Murine) Fragile X Mental Retardation, Autosomal Homolog 1 (FXR1) interaction partners

  1. FXR1P is a GSK3beta substrate with a role in regulating mood and emotion processing

  2. Removal of FXR1P from the forebrain of postnatal mice selectively enhances long-term storage of spatial memories, hippocampal late-phase long-term potentiation (L-LTP), and de novo GluA2 synthesis.

  3. FXR1P was highly expressed during hippocampal development and co-localized with ribosomes and mRNAs in the dendrite and at a subset of spines.

  4. FXR1P is required for efficient processing of pre-microR-9 and pre-microR-124 in vitro and forms a complex with Dicer and pre-miRNAs.

  5. Fxr1 knockout hearts exhibit an up-regulation of desmoplakin and talin2 proteins, which is accompanied by severe disruption of desmosome as well as costamere architecture and composition in the heart

  6. Targeting the p38 mitogen-activated protein kinase pathway of LPS-treated cells with small molecule inhibitors can induce FXR1 protein expression.

  7. Four FXR1 isoforms of molecular weight 70, 74, 78, 80 kDa are widely distributed in mouse organs, while in striated muscles these isoforms are replaced by proteins of 82 and 84 kDa containing an extra pocket of 27 amino acids.

  8. FXR1P operates as a repressor of TNF translation

  9. the data clearly demonstrate the importance of FXR1P RBP in the regulation of a wide spectrum of inflammatory genes and suggest an important role of MAP signalling in the response of macrophages to selected TLR ligands, including CpG.

  10. Fxr1 regulates mammalian circadian behavioral rhythms.

  11. FXR1P and FXR2P KH2 domains bind G-quadruplex and kissing complex RNA with the same affinity as the FMRP KH2 domain.

Xenopus laevis Fragile X Mental Retardation, Autosomal Homolog 1 (FXR1) interaction partners

  1. Fxr1 plays a vital role during Xenopus embryogenesis. Knockdown of Fxr1 has highly muscle-specific effects leading to disruption of MyoD expression, inhibition of somite myotomal cell rotation and segmentation, and abnormal dermatome formation.

FXR1 Antigen Profile

Protein Summary

The protein encoded by this gene is an RNA binding protein that interacts with the functionally-similar proteins FMR1 and FXR2. These proteins shuttle between the nucleus and cytoplasm and associate with polyribosomes, predominantly with the 60S ribosomal subunit. Three transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with FXR1

  • FMR1 autosomal homolog 1 (FXR1) antibody
  • fragile X mental retardation, autosomal homolog 1 (fxr1) antibody
  • FMR1 autosomal homolog 1 (Fxr1) antibody
  • fragile X mental retardation, autosomal homolog 1 (FXR1) antibody
  • FMR1 autosomal homolog 1 (fxr1) antibody
  • fragile X mental retardation gene 1, autosomal homolog (Fxr1) antibody
  • FMR1 autosomal homolog 1 L homeolog (fxr1.L) antibody
  • FMR1 autosomal homolog 1 S homeolog (fxr1.S) antibody
  • 1110050J02Rik antibody
  • 9530073J07Rik antibody
  • AI851072 antibody
  • fxr1 antibody
  • fxr1h antibody
  • Fxr1p antibody
  • wu:fb16f11 antibody
  • wu:fd18c10 antibody
  • xfxr1 antibody
  • xFxr1p antibody
  • XtFxr1p antibody
  • zgc:66226 antibody

Protein level used designations for FXR1

fragile X mental retardation syndrome-related protein 1 , hFXR1p , fragile X mental retardation gene 1, autosomal homolog , fragile X mental retardation-related protein 1 , Fragile X mental retardation syndrome-related protein 1 homolog , fragile X mental retardation syndrome-related protein 1 homolog , fragile X mental retardation, autosomal homolog 1 , fragile X mental retardation syndrome-related protein 1-like , fragile X mental retardation gene, autosomal homolog , fragile-X-related protein 1 , mFxr1p , FXR1 , fragile X mental retardation syndrome-related protein 1 homolog A , xFxr1p-A , fragile X-related protein , Fragile X mental retardation syndrome related protein 1 , fragile X mental retardation syndrome-related protein 1 homolog B , xFxr1p-B

GENE ID SPECIES
8087 Homo sapiens
327220 Danio rerio
361927 Rattus norvegicus
424968 Gallus gallus
478642 Canis lupus familiaris
536793 Bos taurus
594894 Xenopus (Silurana) tropicalis
710170 Macaca mulatta
746398 Pan troglodytes
100066076 Equus caballus
100172974 Pongo abelii
100340080 Oryctolagus cuniculus
100399500 Callithrix jacchus
100595780 Nomascus leucogenys
14359 Mus musculus
398050 Xenopus laevis
100689323 Cricetulus griseus
100155866 Sus scrofa
380114 Xenopus laevis
100714193 Cavia porcellus
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