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The protein encoded by FXR1 is an RNA binding protein that interacts with the functionally-similar proteins FMR1 and FXR2. Additionally we are shipping FXR1 Proteins (4) and and many more products for this protein.
Showing 10 out of 100 products:
Mouse (Murine) Polyclonal FXR1 Primary Antibody for WB - ABIN1881357
Coffee, Tessier, Woodruff, Broadie: Fragile X mental retardation protein has a unique, evolutionarily conserved neuronal function not shared with FXR1P or FXR2P. in Disease models & mechanisms 2010
Show all 5 Pubmed References
Human Polyclonal FXR1 Primary Antibody for IF (p), IHC (p) - ABIN710891
Zhao, Xu, Yuan, Jiang, Zhou, Li, Yin, Zhou, Zhang, Wang: 8-Methoxypsoralen disrupts MDR3-mediated phospholipids efflux and bile acid homeostasis and its relevance to hepatotoxicity. in Toxicology 2017
Human Polyclonal FXR1 Primary Antibody for ICC, IF - ABIN4312875
Fischer-Kešo, Breuninger, Hofmann, Henn, Röhrig, Ströbel, Stoecklin, Hofmann: Plakophilins 1 and 3 bind to FXR1 and thereby influence the mRNA stability of desmosomal proteins. in Molecular and cellular biology 2014
in head and neck squamous cell carcinoma, fragile X mental retardation syndrome related protein 1 (Fxr1) overexpression correlates with reduced F-box protein 4 (Fbxo4 (show FBXO4 Antibodies)) levels.
Inhibition of the remaining family member FXR1 selectively blocks cell proliferation in human cancer cells containing homozygous deletion of both TP53 (show TP53 Antibodies) and FXR2 (show FXR2 Antibodies) in a collateral lethality manner.
Our findings support our a priori hypothesis of a possible interaction between GSK3B (rs12630592 T allele) and FXR1 (rs496250 A allele) in mood disorder patients.
human microbiota was able to reduce the levels of tauro-beta-muricholic acid and induce expression of FXR (show NR1H4 Antibodies) target genes Fgf15 and Shp (show LAMC1 Antibodies) in ileum after long-term colonization. We show that a human microbiota can change BA composition and induce FXR (show NR1H4 Antibodies) signaling in colonized mice, but the levels of secondary BAs produced are lower than in mice colonized with a mouse microbiota
These data reveal a new role of FXR1 in controlling induction of monocyte migration.
FXR1 binds and destabilizes p21 (show CDKN1A Antibodies) mRNA, binds and stabilizes TERC RNA and suppresses the cellular senescence in oral cancer cells.
FXR1P interacts with CMAS, and that FXR1P may enhance the activation of sialic acid via interaction with CMAS, and increase GM1 levels to affect the development of the nervous system, thus providing evidence for further research into the pathogenesis of FXS.
P97 (show EIF4G2 Antibodies) interacts with 3' UTR (show UTS2R Antibodies)-binding FXR1a-associated microRNPs and with PARN (show PARN Antibodies), which binds mRNA 5' caps (show CAPS Antibodies), forming a specialized complex to translate recruited mRNAs in these altered canonical translation conditions.
An accumulation of 8 SNPs in the fragile gene family (FMR1 (show FMR1 Antibodies), FXR1 and FXR2 (show FXR2 Antibodies))were found associated with autistic traits in a sample of male patients.
FXR1P is a GSK3beta substrate with a role in regulating mood and emotion processing
Removal of FXR1P from the forebrain of postnatal mice selectively enhances long-term storage of spatial memories, hippocampal late-phase long-term potentiation (L-LTP (show SCP2 Antibodies)), and de novo GluA2 (show GRIA2 Antibodies) synthesis.
FXR1P was highly expressed during hippocampal development and co-localized with ribosomes and mRNAs in the dendrite and at a subset of spines.
FXR1P is required for efficient processing of pre-microR-9 and pre-microR-124 in vitro and forms a complex with Dicer (show DICER1 Antibodies) and pre-miRNAs.
Fxr1 knockout hearts exhibit an up-regulation of desmoplakin (show DSP Antibodies) and talin2 proteins, which is accompanied by severe disruption of desmosome as well as costamere architecture and composition in the heart
Targeting the p38 mitogen-activated protein kinase (show MAPK14 Antibodies) pathway of LPS (show TLR4 Antibodies)-treated cells with small molecule inhibitors can induce FXR1 protein expression.
Four FXR1 isoforms of molecular weight 70, 74, 78, 80 kDa are widely distributed in mouse organs, while in striated (show NSDHL Antibodies) muscles these isoforms are replaced by proteins of 82 and 84 kDa containing an extra pocket of 27 amino acids.
FXR1P operates as a repressor of TNF (show TNF Antibodies) translation
the data clearly demonstrate the importance of FXR1P RBP (show RBP4 Antibodies) in the regulation of a wide spectrum of inflammatory genes and suggest an important role of MAP signalling in the response of macrophages to selected TLR ligands, including CpG.
Fxr1 regulates mammalian circadian behavioral rhythms.
Fxr1 plays a vital role during Xenopus embryogenesis. Knockdown of Fxr1 has highly muscle-specific (show EIF3K Antibodies) effects leading to disruption of MyoD (show MYOD1 Antibodies) expression, inhibition of somite myotomal cell rotation and segmentation, and abnormal dermatome formation.
The protein encoded by this gene is an RNA binding protein that interacts with the functionally-similar proteins FMR1 and FXR2. These proteins shuttle between the nucleus and cytoplasm and associate with polyribosomes, predominantly with the 60S ribosomal subunit. Three transcript variants encoding different isoforms have been found for this gene.
fragile X mental retardation syndrome-related protein 1
, fragile X mental retardation gene 1, autosomal homolog
, fragile X mental retardation-related protein 1
, Fragile X mental retardation syndrome-related protein 1 homolog
, fragile X mental retardation syndrome-related protein 1 homolog
, fragile X mental retardation, autosomal homolog 1
, fragile X mental retardation syndrome-related protein 1-like
, fragile X mental retardation gene, autosomal homolog
, fragile-X-related protein 1
, fragile X mental retardation syndrome-related protein 1 homolog A
, fragile X-related protein
, Fragile X mental retardation syndrome related protein 1
, fragile X mental retardation syndrome-related protein 1 homolog B