anti-Free Fatty Acid Receptor 2 (FFAR2) Antibodies

Human Free Fatty Acid Receptor 2 (FFAR2) interaction partners

1. Compared with the control group, the densitometric quantification and mean density of GPR43 and ChAT proteins, and expression of GPR43 and CHAT genes, were significantly decreased in the patients with mixed refractory constipation.

2. a single dose of soluble fibre was able to significantly reduce airway inflammation in stable asthma by downregulating GPR43 and GPR41 (show FFAR3 Antibodies)

3. Short-chain fatty acids lowered TNF-alpha (show TNF Antibodies)-induced MCP-1 (show CCL2 Antibodies) expression by reducing phosphorylation of p38 MAPK (show MAPK14 Antibodies) and JNK (show MAPK8 Antibodies) in a GPR41 (show FFAR3 Antibodies)/GRP43-dependent manner in renal cortical epithelial cells.

4. FFA2 processes mediated by Gi signaling, whereas, in concert with blockade by the Gq/G11 (show STK19 Antibodies) inhibitor FR900359, the inability of AZ1729 to mimic or regulate propionate-mediated release of GLP-1 (show GCG Antibodies) from mouse colonic preparations defined this physiological response as an end point transduced via activation of Gq/G11 (show STK19 Antibodies).

5. the results of mutagenesis studies based on the crystal structure of hFFA1 bound to TAK (show CDK9 Antibodies)-875 at 2.3 A resolution to identify important residues for orthosteric agonist 6e inducing FFA2 activation.

6. Although both agonist and antagonist ligands contain negatively charged carboxylates that interact with two key positively charged arginine residues in transmembrane domains V and VII (show TH Antibodies) of FFA2, there are clear differences in how these interactions occur.

7. FFAR2 signaling occurs by divergent G protein pathways.

8. GPR3 agonism potentiates insulin secretion in isolated islets.

9. GPR43 expression is reduced in monocytes upon siRNA-knockdown of XBP1 (show XBP1 Antibodies), while A549 cells overexpressing XBP1 (show XBP1 Antibodies) displayed elevated GPR43 levels.

10. FFAR2 is a potential therapeutic target of T1 diabetes, representing a link between immune response and glucose homeostasis.

Mouse (Murine) Free Fatty Acid Receptor 2 (FFAR2) interaction partners

1. this paper show that microbiota metabolite short-chain fatty acid acetate promotes intestinal IgA (show IgA Antibodies) response to microbiota which is mediated by GPR43

2. dual oxidase-2 (show DUOX1 Antibodies) and IL-6 (show IL6 Antibodies) play important roles in GPR43-mediated skin inflammation.

3. Loss of Ffar2 expression is associated with leukemia.

4. the role of GPR43 in adipose tissue macrophages, was examined.

5. loss of FFAR2 is associated with colon tumorigenesis.

6. Gestational glucose tolerance in WT mice, but not Ffar2-/- mice improved while on antibiotics. Gestational glucose tolerance worsened in Ffar2-/- mice during a second pregnancy. Maternal Ffar2 expression had no effect on the growth rates and glucose and glucose tolerance in the offspring.

7. FFA2 processes mediated by Gi signaling, whereas, in concert with blockade by the Gq/G11 (show STK19 Antibodies) inhibitor FR900359, the inability of AZ1729 to mimic or regulate propionate-mediated release of GLP-1 (show GCG Antibodies) from mouse colonic preparations defined this physiological response as an end point transduced via activation of Gq/G11 (show STK19 Antibodies).

8. A Western diet could aggravate the inflammatory colitis process; the activation of the GPR43 receptor pathway could be used as a new strategy to treat Crohn's Disease patients.

9. FFAR2 signaling occurs by divergent G protein pathways.

10. Data (including data from studies in knockout mice) suggest Ffar2 expression in pancreatic beta-cells plays role in gestational glucose homeostasis; this mechanism involves gut microbiome (which contributes to plasma short-chain fatty acid levels).