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Receptor for short chain fatty acids. Additionally we are shipping FFAR3 Antibodies (47) and FFAR3 Proteins (7) and many more products for this protein.
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An inverse regulation of FFAR2 (show FFAR2 ELISA Kits) and FFAR3 expression over time and both receptors also showed an inverse mRNA abundance as induced by different portions of concentrate. Thus, indicating divergent nutrient sensing of both receptors in adipose tissues (AT) during the transition period.
GPR41 gene contains 3 exons and its transcription is initiated at 2 leader exons, generating 2 GPR41 mRNA variants differing in the 5' untranslated region
Data suggest that cytokines TNFalpha (show TNF ELISA Kits) and interleukin-1b markedly reduce GPR120/FFAR4 (show O3FAR1 ELISA Kits) expression in adipocytes; in contrast, these cytokines induce expression of GPR84 and GPR41/FFAR3 in adipocytes. These studies were conducted in adipocytes cultured from subcutaneous adipose tissue. (GPR (show ALDH18A1 ELISA Kits) = G-protein coupled receptor (show ADRA1A ELISA Kits); FFAR = free fatty acid receptor)
a single dose of soluble fibre was able to significantly reduce airway inflammation in stable asthma by downregulating GPR43 (show FFAR2 ELISA Kits) and GPR41
Short-chain fatty acids lowered TNF-alpha (show TNF ELISA Kits)-induced MCP-1 (show CCL2 ELISA Kits) expression by reducing phosphorylation of p38 MAPK (show MAPK14 ELISA Kits) and JNK (show MAPK8 ELISA Kits) in a GPR41/GRP43-dependent manner in renal cortical epithelial cells.
Our data suggest that GPR42 be reclassified as a functioning gene and that recognition of sequence and copy number polymorphism of the FFAR3/GPR42 complex be considered during genetic and pharmacological investigation of these receptors.
FFAR3 is expressed in pancreatic beta cells and mediates an inhibition of insulin (show INS ELISA Kits) secretion by coupling to Gi-type G proteins.
a significant correlation between a higher body mass index and lower methylation in the promoter region of FFAR3 in type 2 diabetes and obesity patients
Propionate-stimulated GPR41 strongly coupled to ERK1/2 (show MAPK1/3 ELISA Kits) activation, while the coupling of linoleic acid-activated GPR40 (show FFAR1 ELISA Kits) and acetate-activated GPR43 (show FFAR2 ELISA Kits) was weaker.
GPR41 activation inhibits histone acetylation and cell growth.
GPR41 gene expression is mediated by internal ribosome entry site (IRES)-dependent translation of bicistronic mRNA encoding GPR40 (show FFAR1 ELISA Kits) and GPR41 proteins
Selective orthosteric free fatty acid receptor 2 (show FFAR2 ELISA Kits) (FFA2) agonists: identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3.
Gpr41 KO mice have hypertension of a vascular origin.
the maternal microbiome influences Treg differentiation in the thymus of offspring through GPR41-mediated Aire (show AIRE ELISA Kits) expression
that GPR41 and its ligands, short-chain fatty acids, may play an important role in the fine-tuning of insulin (show INS ELISA Kits) secretion in fed and fasting states
Pharmacological and knockdown experiments showed that activation of sympathetic neurons by SCFA propionate involves SCFA receptor GPR41 linking to Gbetagamma-PLCbeta3-ERK1/2 (show MAPK1/3 ELISA Kits)-synapsin 2 (show SYN2 ELISA Kits)
mediates beta cell glucose stimulated insulin (show INS ELISA Kits) secretion through Galphai/o sensitive pathway
Results indicate that FFAR3 is expressed on postganglionic sympathetic and sensory neurons in both the autonomic and somatic peripheral nervous system
Data from transgenic mice suggest that Ffar3/Gpr41 and Ffar2/Gpr43 (show FFAR2 ELISA Kits) both act as sensors for short-chain fatty acids in enteroendocrine cells; Ffar3/Gpr41 appears to play this role alone in enteric neurons and Ffar2/Gpr43 (show FFAR2 ELISA Kits) alone in enteric leukocytes.
Short-chain fatty acids activate GPR41 and on intestinal epithelial cells, leading to mitogen-activated protein kinase (show MAPK1 ELISA Kits) signaling and rapid production of chemokines and cytokines. These pathways mediate protective immunity and tissue inflammation in mice.
Receptor for short chain fatty acids. The activity of this receptor is coupled to the formation of inositol 1,4,5- trisphosphate, intracellular Ca2+ mobilization, the activation of ERK 1/2 and inhibition of intracellular cAMP accumulation. Coupled exclusively to the pertussis toxin-sensitive G(i/o)-alpha protein. The rank order of potency for agonists of this receptor is propionate = pentanoate = butyrate > acetate > formate.
free fatty acid receptor 3
, G protein-coupled receptor 41
, G-protein coupled receptor 41
, putative G protein-coupled receptor GPR41