Free Fatty Acid Receptor 3 (FFAR3) ELISA Kits

Receptor for short chain fatty acids. Additionally we are shipping FFAR3 Antibodies (50) and FFAR3 Proteins (7) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human FFAR3 FFAR3 2865 O14843
FFAR3 365228  
FFAR3 233080 Q3UFD7
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Top FFAR3 ELISA Kits at antibodies-online.com

Showing 2 out of 7 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Mouse 0.053 ng/mL 0.15 ng/mL - 10 ng/mL 96 Tests Log in to see 13 to 16 Days
$682.11
Details
Rat 0.059 ng/mL 0.15 ng/mL - 10 ng/mL   96 Tests Log in to see 13 to 16 Days
$1,003.44
Details

More ELISA Kits for FFAR3 Interaction Partners

Cow (Bovine) Free Fatty Acid Receptor 3 (FFAR3) interaction partners

  1. An inverse regulation of FFAR2 and FFAR3 expression over time and both receptors also showed an inverse mRNA abundance as induced by different portions of concentrate. Thus, indicating divergent nutrient sensing of both receptors in adipose tissues (AT) during the transition period.

  2. GPR41 gene contains 3 exons and its transcription is initiated at 2 leader exons, generating 2 GPR41 mRNA variants differing in the 5' untranslated region

Human Free Fatty Acid Receptor 3 (FFAR3) interaction partners

  1. FFAR2 and FFAR3 interact to form a heteromer in primary monocytes and macrophages via proximity ligation assay, and during heterologous expression in HEK293 cells via bimolecular fluorescence complementation and fluorescence resonance energy transfer. FFAR2 and FFAR3 may interact to form a receptor heteromer with signaling that is distinct from the parent homomers.

  2. Data suggest that cytokines TNFalpha and interleukin-1b markedly reduce GPR120/FFAR4 expression in adipocytes; in contrast, these cytokines induce expression of GPR84 and GPR41/FFAR3 in adipocytes. These studies were conducted in adipocytes cultured from subcutaneous adipose tissue. (GPR = G-protein coupled receptor; FFAR = free fatty acid receptor)

  3. a single dose of soluble fibre was able to significantly reduce airway inflammation in stable asthma by downregulating GPR43 and GPR41

  4. Short-chain fatty acids lowered TNF-alpha-induced MCP-1 expression by reducing phosphorylation of p38 MAPK and JNK in a GPR41/GRP43-dependent manner in renal cortical epithelial cells.

  5. Our data suggest that GPR42 be reclassified as a functioning gene and that recognition of sequence and copy number polymorphism of the FFAR3/GPR42 complex be considered during genetic and pharmacological investigation of these receptors.

  6. FFAR3 is expressed in pancreatic beta cells and mediates an inhibition of insulin secretion by coupling to Gi-type G proteins.

  7. a significant correlation between a higher body mass index and lower methylation in the promoter region of FFAR3 in type 2 diabetes and obesity patients

  8. Propionate-stimulated GPR41 strongly coupled to ERK1/2 activation, while the coupling of linoleic acid-activated GPR40 and acetate-activated GPR43 was weaker.

  9. Extracellular ionic locks determine variation in constitutive activity and ligand potency between species orthologs of the free fatty acid receptors FFA2 and FFA3

  10. GPR41 activation inhibits histone acetylation and cell growth.

  11. GPR41 gene expression is mediated by internal ribosome entry site (IRES)-dependent translation of bicistronic mRNA encoding GPR40 and GPR41 proteins

  12. Selective orthosteric free fatty acid receptor 2 (FFA2) agonists: identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3.

  13. characterization of GP41 in human tissue as a receptor for short chain fatty acids

  14. C2-C6 short-chain fatty acids, ligands of an orphan G protein-coupled receptor GPR41, stimulate leptin expression in both a mouse adipocyte cell line and mouse adipose tissue in primary culture

  15. GPR41 and 43 mediate SCFA signaling in mammary epithelial cells and thereby play an important role in their stress management.

  16. analysis of conserved polar residues in transmembrane domains V, VI, and VII of free fatty acid receptor 2 and free fatty acid receptor 3 are required for the binding and function of short chain fatty acids

  17. Results suggest that GPR41 expressed in human colonic mucosa may function as a sensor for luminal short-chain fatty acids.

  18. Study presents evidence showing that the six amino acid differences, including that R/W174 are polymorphisms rather than gene-specific differences between GPR41 and GPR42.

Mouse (Murine) Free Fatty Acid Receptor 3 (FFAR3) interaction partners

  1. Gpr41 KO mice have hypertension of a vascular origin.

  2. the maternal microbiome influences Treg differentiation in the thymus of offspring through GPR41-mediated Aire expression

  3. that GPR41 and its ligands, short-chain fatty acids, may play an important role in the fine-tuning of insulin secretion in fed and fasting states

  4. Pharmacological and knockdown experiments showed that activation of sympathetic neurons by SCFA propionate involves SCFA receptor GPR41 linking to Gbetagamma-PLCbeta3-ERK1/2-synapsin 2

  5. mediates beta cell glucose stimulated insulin secretion through Galphai/o sensitive pathway

  6. Results indicate that FFAR3 is expressed on postganglionic sympathetic and sensory neurons in both the autonomic and somatic peripheral nervous system

  7. FFAR3 is expressed in pancreatic beta cells and mediates an inhibition of insulin secretion by coupling to Gi-type G proteins.

  8. Data from transgenic mice suggest that Ffar3/Gpr41 and Ffar2/Gpr43 both act as sensors for short-chain fatty acids in enteroendocrine cells; Ffar3/Gpr41 appears to play this role alone in enteric neurons and Ffar2/Gpr43 alone in enteric leukocytes.

  9. Short-chain fatty acids activate GPR41 and on intestinal epithelial cells, leading to mitogen-activated protein kinase signaling and rapid production of chemokines and cytokines. These pathways mediate protective immunity and tissue inflammation in mice.

  10. Extracellular ionic locks determine variation in constitutive activity and ligand potency between species orthologs of the free fatty acid receptors FFA2 and FFA3

  11. GPR41 gene expression is mediated by internal ribosome entry site (IRES)-dependent translation of bicistronic mRNA encoding GPR40 and GPR41 proteins

  12. Short chain fatty acids and ketone bodies directly regulate GPR41-mediated sympathetic nervous system activity and thereby control body energy expenditure in maintaining metabolic homeostasis.

  13. Acetate and propionate short chain fatty acids may have important physiological roles in adipogenesis through GPCR43, but not through GPCR41.

  14. Gpr41 is a regulator of host energy balance through effects that are dependent upon the gut microbiota

  15. In this review, the mechanism of receptor activation, pharmacology, and the physiological functions of the fatty acid binding receptors GPR40, GPR41, GPR43, and GPR119 are discussed.

FFAR3 Antigen Profile

Antigen Summary

Receptor for short chain fatty acids. The activity of this receptor is coupled to the formation of inositol 1,4,5- trisphosphate, intracellular Ca2+ mobilization, the activation of ERK 1/2 and inhibition of intracellular cAMP accumulation. Coupled exclusively to the pertussis toxin-sensitive G(i/o)-alpha protein. The rank order of potency for agonists of this receptor is propionate = pentanoate = butyrate > acetate > formate.

Gene names and symbols associated with FFAR3

  • free fatty acid receptor 3 (LOC455946) antibody
  • free fatty acid receptor 3 (FFAR3) antibody
  • free fatty acid receptor 3 (LOC100600134) antibody
  • free fatty acid receptor 3 (Ffar3) antibody
  • FFA3R antibody
  • Gm478 antibody
  • Gpr41 antibody

Protein level used designations for FFAR3

free fatty acid receptor 3 , G protein-coupled receptor 41 , G-protein coupled receptor 41 , putative G protein-coupled receptor GPR41

GENE ID SPECIES
455946 Pan troglodytes
527517 Bos taurus
612659 Canis lupus familiaris
708732 Macaca mulatta
100600134 Nomascus leucogenys
2865 Homo sapiens
365228 Rattus norvegicus
233080 Mus musculus
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