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FLI1 encodes a transcription factor containing an ETS DNA-binding domain. Additionally we are shipping Friend Leukemia Virus Integration 1 Antibodies (158) and Friend Leukemia Virus Integration 1 Proteins (7) and many more products for this protein.
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CXCL6 expression is upregulated by Fli1 deficiency in fibroblasts and endothelial cells, potentially contributing to the development of fibrosis and vasculopathy in the skin, lung, and heart of systemic sclerosis.
This is the first report presenting CD13 (show ANPEP ELISA Kits) and FLI1 as important mediators of resistance to BRAF (show BRAF ELISA Kits) inhibition with potential as drug targets in BRAF (show BRAF ELISA Kits) inhibitors refractory melanoma.
This study uncovers FLI1 as an important driving factor that promotes tumor growth in SCLC through the miR-17-92 pathway. FLI1 may serve as an attractive target for therapeutic intervention of SCLC.
identification of two novel FLI1 variants (c.1010G>A and c.1033A>G) responsible for macrothrombocytopenia; study provides new insights into the phenotype, pathophysiology and diagnosis of FLI1 variant-associated thrombocytopenia
miR (show MLXIP ELISA Kits)-145 acts as a tumor suppressor by directly reducing expression of FLI-1, and the miR (show MLXIP ELISA Kits)-145/FLI-1 pathway is important for tumor progression in osteosarcoma
this paper provides a mechanistic insight into the regulation of angiogenesis by TLRs and confirm a central role of Fli1 in regulating vascular homeostasis.
Recent advances in biologic and genomic understanding of these two cancers has expanded the potential for therapeutic advancement and prevention. In Ewing sarcoma, directed focus on inhibition of EWSR1 (show EWSR1 ELISA Kits)-FLI1 and its effectors has produced promising results.
Fusion of short fragments of EWSR1 (show EWSR1 ELISA Kits) to FLI1 is sufficient to recapitulate BAF complex retargeting and EWS (show EWSR1 ELISA Kits)-FLI1 activities; studies thus demonstrate that the physical properties of prion (show PRNP ELISA Kits)-like domains can retarget critical chromatin regulatory complexes to establish and maintain oncogenic gene expression programs.
In American cutaneous leishmaniasis caused by Leishmania braziliensis infection, MMP1 (show MMP1 ELISA Kits) is regulated by factors other than FLI1, and the influence of IL-6 (show IL6 ELISA Kits) on MMP1 (show MMP1 ELISA Kits) was independent of its effect on FLI1.
epithelial Fli1 deficiency might be involved in the systemic autoimmunity and selective organ fibrosis in systemic sclerosis (SSc (show CYP11A1 ELISA Kits)).
Histones showed limited activation in regions of single TF binding, while enhancers that bind NF-E2 and either RUNX1 (show RUNX1 ELISA Kits), FLI1 or both TFs gave the highest signals for TF occupancy and H3K4me2; these enhancers associated best with genes activated late in MK maturation.
loss of ERG (show ERG ELISA Kits) and FLI1 might contribute to the pathogenesis of vascular lung complications through the induction of inflammation.
These results provide the first evidences that Fli-1 positively regulates LPS (show TLR4 ELISA Kits)-induced IL-27 (show IL27 ELISA Kits) production in macrophages
protective against nephritis MRL/lpr (show FAS ELISA Kits) mice
Fli1 is epigenetically suppressed and is a potential predisposing factor in the pathogenesis of systemic sclerosis. (Review)
The short nose, otitis media, and hearing impairment in Jacobsen syndrome are likely because of hemizygosity for ETS1 (show ETS1 ELISA Kits) and FLI1.
Simultaneous downregulation of KLF5 (show KLF5 ELISA Kits) and Fli1 is a key feature underlying systemic sclerosis.
bosentan...increased DNA binding of Fli1 and the suppression of type I collagen expression in systemic sclerosis fibroblasts
FLI1 and GATA2 (show GATA2 ELISA Kits) are upstream regulators of SMAD1 (show SMAD1 ELISA Kits) and SMAD5 (show SMAD5 ELISA Kits) expression in endothelial cells.
These results demonstrate that Fli-1 is a novel regulator of the proinflammatory chemokine (show CCL1 ELISA Kits) MCP-1 (show CPT1B ELISA Kits).
mesodermal Wnt3a (show WNT3A ELISA Kits)-mediated signaling via the transcription factor Lef1 (show LEF1 ELISA Kits) positively regulates EC specification (defined by kdrl expression) at the expense of primitive erythrocyte specification (defined by gata1 (show GATA1 ELISA Kits) expression) in zebrafish embryos.
Fli+ etsrp+ hemato-vascular progenitor cells proliferate at the lateral plate mesoderm during vasculogenesis in zebrafish.
These results showed that young thrombocytes have higher GATA1 (show GATA1 ELISA Kits) promoter activity, while mature thrombocytes have more fli1 gene promoter transcription.
fli1, and etsrp, demonstrated that erg and fli1 act cooperatively and are required for angiogenesis possibly via direct regulation of an endothelial cell junction molecule, VE-cadherin (show CDH5 ELISA Kits)
Interaction between EWSR1 (show EWSR1 ELISA Kits)/FLI1 and EWSR1 (show EWSR1 ELISA Kits) in Ewing sarcoma may induce mitotic defects leading to genomic instability and subsequent malignant transformation.
This gene encodes a transcription factor containing an ETS DNA-binding domain. The gene can undergo a t(11\;22)(q24\;q12) translocation with the Ewing sarcoma gene on chromosome 22, which results in a fusion gene that is present in the majority of Ewing sarcoma cases. An acute lymphoblastic leukemia-associated t(4\;11)(q21\;q23) translocation involving this gene has also been identified. Alternative splicing results in multiple transcript variants.
Ewing sarcoma breakpoint region 2
, Friend leukemia integration 1 transcription factor
, Friend leukemia virus integration 1
, proto-oncogene Fli-1
, transcription factor ERGB
, fli-1 proto-oncogene
, friend leukemia integration 1 transcription factor-like
, Friend leukemia integration 1 transcription factor-like
, retroviral integration site protein Fli-1
, retroviral integration site protein Fli-1 homolog