G Protein Pathway Suppressor 2 Proteins (GPS2)

Human G Protein Pathway Suppressor 2 (GPS2) interaction partners

1. These findings, together, reveal an additional layer of regulation of mitochondrial gene transcription, uncover a direct mitochondria-nuclear communication pathway, and indicate that GPS2 retrograde signaling is a key component of the mitochondrial stress response in mammals.

2. The study of adipose tissue from humans with and without obesity revealed correlations between reduced GPS2 expression in macrophages, elevated systemic and adipose tissue inflammation, and diabetic status.

3. our studies identify GPS2 functions as a tumor suppressor in LPS and its downregulation is correlated to prognosis of LPS.

4. Posttranslational modification of GPS2 by SUMOylation may serve as a key factor that regulates the function of GPS2 in vivo.

5. regulation of GPS2 by posttranslational modifications provides an effective strategy for modulating its molecular function within the nuclear compartment.

6. Chromosomal translocation in a pediatric undifferentiated spindle cell sarcoma have characterized this alteration to show rearrangement of the MLL4 and GPS2 genes, resulting in fusion gene MLL4-GPS2, the expression of which promotes independent growth.

7. GPS2 is required for the association of viral NS5A with VAP-A and hepatitis C virus replication.

8. expression of the transcriptional corepressor complex subunits GPS2 and SMRT was significantly reduced in obese adipose tissue, inversely correlated to inflammatory status

9. Results show for the first time that GPS-2 is differentially methylated at a site that lacks known methylation motifs and that the methylation state is detected by the immune system

10. metabolically important coregulator GPS2 functions as a hitherto unrecognized transrepression mediator of interactions between SUMOylated nuclear receptors and the N-CoR corepressor complex

11. Results show that the N-CoR-HDAC3 complex inhibits JNK activation through the associated GPS2 subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP-1 function.

12. the GPS2 might function in concert with hMSH4-hMSH5 during the process of homologous recombination.

13. Direct interactions of GPS2 with hnf4alpha and farnesoid x receptor indicate alternative coregulator recruitment strategies to cause differential transcriptional outcomes in governing bile acid biosynthesis.

14. GPS2 interacts with RFX4_v3 to modulate transactivation of genes involved in brain morphogenesis, including Cx3Cl1

15. Data describe the requirement of GPS2 for ABCG1 gene transcription and cholesterol efflux from macrophages, and implicate GPS2 in facilitating LXRalpha/beta recruitment to an ABCG1-specific promoter/enhancer unit upon ligand activation.

16. G protein pathway suppressor 2 (GPS2) is a transcriptional corepressor important for estrogen receptor alpha-mediated transcriptional regulation.

Mouse (Murine) G Protein Pathway Suppressor 2 (GPS2) interaction partners

1. These findings, together, reveal an additional layer of regulation of mitochondrial gene transcription, uncover a direct mitochondria-nuclear communication pathway, and indicate that GPS2 retrograde signaling is a key component of the mitochondrial stress response in mammals.

2. In macrophage-specific Gps2-knockout mice, inappropriate co-repressor complex function caused enhancer activation, pro-inflammatory gene expression and hypersensitivity toward metabolic-stress signals. By contrast, transplantation of GPS2-overexpressing bone marrow into two mouse models of obesity (ob/ob and diet-induced obesity) reduced inflammation and improved insulin sensitivity.

3. GPS2 is required for restricting the activation of TLR and BCR signaling pathways and the AKT/FOXO1 pathway in immune cells based on direct inhibition of Ubc13 enzymatic activity

4. GPS2 stabilizes KDM4A on target promoters by inhibiting Ubc13/RNF8 ubiquitination.

5. GPS2 binds to active PPARgamma, facilitates its repression by NCoR, and is required for the optimal NCoR corepressor function for PPARgamma.

6. GPS2 as a molecular guardian required for precise control of inflammatory responses involved in immunity and homeostasis.

7. metabolically important coregulator GPS2 functions as a hitherto unrecognized transrepression mediator of interactions between SUMOylated nuclear receptors and the N-CoR corepressor complex