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Adrenomedullin is a potent vasodilator peptide that exerts major effects on cardiovascular function. Additionally we are shipping G Protein-Coupled Receptor 182 Kits (5) and G Protein-Coupled Receptor 182 Proteins (5) and many more products for this protein.
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Our data demonstrate that GPR182 is an endothelial subtype-specific marker for human sinusoidal EC of the liver, spleen, lymph node and bone marrow. In addition, we provide evidence for GPR182-dependent downstream signaling via ERK and SRF pathways that may be involved in regulating endothelial subtype-specific sinusoidal differentiation and sinusoidal functions such as permeability.
Gene expression of adrenomedullin receptor components are differentially regulated in the uterus during the estrous cycle.
ADMR mediates the stimulatory effects of adrenomedullin (show ADM Antibodies) on cancer cells and on endothelial and stellate cells within the tumor microenvironment
Endogenous ADM (show ADM Antibodies) system plays a potentially important role in the paracrine or autocrine functional control of Conn's adenomas.
The cardiovascular response in sepsis: proposed mechanisms of the beneficial effect of adrenomedullin (show ADM Antibodies) and its binding protein (review).
The co-expression of Adm (show ADM Antibodies) and its receptor in perineural fibroblasts and the expression of an Adm (show ADM Antibodies) receptor in Schwann cells suggest autocrine and/or paracrine modes of action of Adm (show ADM Antibodies) in peripheral nerves.
Chondrocyte phenotype cells expressed adrenomedullin (show ADM Antibodies) and the adrenomedullin receptor, and secreted high concentration of adrenomedullin (show ADM Antibodies) into the culture medium
Hybridization in situ showed that ADMR mRNA expression was significantly higher in pulmonary artery walls in patients with chronic obstructive pulmonary disease.
distribution of adrenomedullin receptor (AM-R )in the villous and extravillous trophoblast cells of the placenta and in chorion and decidua cells of the fetal membranes changed with gestational age but not with labor
This putative G protein-coupled receptor (show GPR176 Antibodies) remains an orphan, as the ability to bind and be activated by adrenomedullin (show ADM Antibodies) has been refuted. A complex of CRLR (show CALCRL Antibodies) and RAMP2 (show RAMP2 Antibodies) or RAMP3 (show RAMP3 Antibodies) gives a functional adrenomedullin receptor.
Gpr182 reduction led to increased activation of ERK1/2 in basal and challenge models, demonstrating a potential role for this orphan GPCR in regulating the proliferative capacity of the intestine.
Adrenomedullin is a potent vasodilator peptide that exerts major effects on cardiovascular function. This gene encodes a seven-transmembrane protein that belongs to the family 1 of G-protein coupled receptors. Studies of the rat counterpart suggest that the encoded protein may function as a receptor for adrenomedullin.
G-protein coupled receptor 182
, adrenomedullin receptor
, G protein-coupled receptor 182
, G-protein coupled receptor 182-like