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The anaphylatoxins C3a (see MIM 120700), C4a (see MIM 120810), and C5a are cationic fragments generated during the complement cascade that participate in host defense. Additionally we are shipping G Protein-Coupled Receptor 77 Antibodies (104) and and many more products for this protein.
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Both rs2972607 and rs8112962 SNPs of C5L2 are associated with coronary artery disease in a Han population of China.
Studies indicate that the complement response lie the active fragments, C3a (show C3 ELISA Kits) and C5a, acting through their specific receptors, C3aR (show C3AR1 ELISA Kits), C5aR1 (show C5AR1 ELISA Kits) and C5aR2 to direct the cellular response to inflammation.
negative regulator of BDNF (show BDNF ELISA Kits) secretion by pulp fibroblasts under carious teeth
All the C698T genotypes and allele frequencies in C5L2 were almost similar in both the cases and controls.
C5AR (show C5AR1 ELISA Kits) and C5L2-mediated neutrophil dysfunction is associated with a poor outcome in sepsis.
this study reveals a novel role for C5aR2 in C5a-mediated activation of mast cells and demonstrates that C5aR2 ligation initiates a beta-arrestin-2 (show ARRB2 ELISA Kits)-, PI3K (show PIK3CA ELISA Kits)-, and ERK (show EPHB2 ELISA Kits)-dependent signaling pathway in these cells.
C5a2 can modulate ERK1/2 signaling in macrophages via heteromer formation with C5a1 and beta-arrestin recruitment.
prominent C5L2 expression in advanced atherosclerotic stages directly correlates with high levels of proinflammatory cytokines
The present study has extended the mutation spectrum of C5L2, and Thr196Asn mutations in C5L2 were associated with retinitis pigmentosa and serum lipid levels.
C5aR (show C5AR1 ELISA Kits) and C5L2 may have roles in adiposity in women
The role of C5aR1 (show C5AR1 ELISA Kits) and C5aR2 in response to renal ischemia-reperfusion injury is reported. The results also demonstrated that C5aR2 is a functional receptor, rather than a decoy receptor, and may provide a new target for intervention.
C5L2 plays an important antiinflammatory role.
Findings demonstrate that, under excitotoxicity, Fosb (show FOSB ELISA Kits) products contribute to a neuroinflammatory response in the hippocampus through regulation of microglial C5ar1 (show C5AR1 ELISA Kits) and C5ar2 expression
This work reveals an essential role for C5L2 in C5a-triggered, AP2 (show TFAP2A ELISA Kits)-dependent C5aR (show C5AR1 ELISA Kits) internalization and downstream ERK (show EPHB2 ELISA Kits) signaling.
Mouse susceptibility to MHV-3-induced fulminant hepatitis may rely on C5a/C5aR interactions, for which ERK1/2 (show MAPK1/3 ELISA Kits) and p38 (show CRK ELISA Kits) pathways participate in up-regulating Fgl2 (show FGL2 ELISA Kits) expression.
These observations indicate the importance of C5aR (show C5AR1 ELISA Kits) in adipose tissue metabolism and immunity, which may be regulated through heterodimerization with C5L2.
in allergic contact sensitivity, as in isolated human neutrophils, C5L2 functions to suppress C5a-C5aR-mediated responses, further underscoring its role as a negative regulator of anaphylatoxin activity.
Disruption of C5L2 increases macrophage presence in white adipose tissue, contributing to obesity-associated pathologies.
C5L2 is a functional receptor for ASP (show C3 ELISA Kits) and act as a decoy receptor for C5a in pathophysiological conditions.
These findings elucidate the functional characteristics of the C5L2 receptor during the acute inflammatory response.
This gene encodes a G-protein coupled receptor 1 family member involved in the complement system of the innate immune response. Unlike classical G-protein coupled receptors, the encoded protein does not associate with intracellular G-proteins. It may instead modulate signal transduction through the beta-arrestin pathway, and may alternatively act as a decoy receptor. This gene may be involved in coronary artery disease and in the pathogenesis of sepsis. Alternative splicing results in multiple transcript variants.
G protein-coupled receptor 77
, G protein-coupled receptor C5L2
, C5a anaphylatoxin chemotactic receptor 2
, C5a anaphylatoxin chemotactic receptor C5L2
, G-protein coupled receptor 77
, C5A receptor beta
, complement 5A receptor beta