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seven transmembrane domain G-protein coupled receptor\; most often found in sensory neurons [RGD, Feb 2006].. Additionally we are shipping G Protein-Coupled Receptor MRGX2 Antibodies (89) and G Protein-Coupled Receptor MRGX2 Kits (4) and many more products for this protein.
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Low levels of MRGPRX2 were detected in non-asthma lung mast cells, but its expression was significantly up-regulated in asthma lung mast cells.
the present study demonstrates that FceRI (show FCER1A Proteins) and MRGPRX2 function can be inversely regulated by SCF (show KITLG Proteins) in an acute scenario, suggesting that the signaling requirements differ profoundly between the routes.
The authors discuss the possibility that MRGPRX2 responds to various as-yet-unidentified endogenous ligands that have specific characteristics, and propose that MRGPRX2 plays an important role in regulating inflammatory responses to endogenous harmful stimuli, such as protein breakdown products released from damaged or dying cells.
these peptides are identified as fragments of albumin (show ALB Proteins). The isolated fragments activate MRGPRX2 and degranulate MRGPRX2 expressing LAD (show DLD Proteins) 2 cells in dose-dependent manner. The isolated basic peptides generated from human albumin (show ALB Proteins) are able to degranulate mast cells via the MRGPRX2.
The results showed a kind of mechanism that sinomenine-induced anaphylactoid reactions were mediated by MRGPRX2 via activating PLC (show HSPG2 Proteins) molecular signaling pathways to provoke mast cells Ca(2 (show CA2 Proteins)+) mobilization and degranulation.
data suggest that mast cells play important roles in both gingival homeostasis and periodontal disease by orchestrating an interaction between gingival epithelial cells and neutrophils via MRGPRX2-mediated degranulation
MRGX2 is related to nociception, adrenal gland secretion and mast cell degranulation. (Review)
Ectopic expression of MrgX2 in rat basophilic leukemia RBL-2H3 cells and murine bone marrow mast cells renders these cells responsive to human beta-defensin (show DEFB1 Proteins) for degranulation.
identified MrgX2 as a novel G protein-coupled receptor for the antibacterial peptide LL-37 and demonstrated that unlike most G protein-coupled receptors it is resistant to agonist-induced receptor phosphorylation, desensitization, and internalization.
cortistatin-14 (show CORT Proteins) shown to be a high affinity ligand for G protein coupled receptor MrgX2 which is expressed in dorsal root ganglion
seven transmembrane domain G-protein coupled receptor\; most often found in sensory neurons
G protein-coupled receptor MRGX2
, mas-related G-protein coupled receptor member X2
, MAS-related GPR, member B10
, mas-related G-protein coupled receptor member B10
, MAS-related G protein-coupled receptor, member B1
, MAS-related gene B1