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The protein encoded by GTSE1 is only expressed in the S and G2 phases of the cell cycle, where it colocalizes with cytoplasmic tubulin and microtubules. Additionally we are shipping GTSE1 Kits (4) and GTSE1 Proteins (3) and many more products for this protein.
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Human Polyclonal GTSE1 Primary Antibody for WB - ABIN526771
Cheeseman, Harry, McAinsh, Prior, Royle: Specific removal of TACC3-ch-TOG-clathrin at metaphase deregulates kinetochore fiber tension. in Journal of cell science 2013
High expression of GTSE1 is commonly noted in hepatocellular carcinoma (HCC) and is closely correlated with migration and invasion by epithelial-to-mesenchymal transition modulation. Activated GTSE1 significantly interferes with chemotherapy efficacy and influences the probability of survival of patients with HCC.
G2 and S-phase expressed 1 (GTSE1) expression promotes AM progression and correlates with clinical outcomes of patients with acral melanoma (AM), and may represent a promising therapeutic target to suppress AM progression.
GTSE1 is expressed exclusively in late G2 and M phase. From nuclear envelope breakdown until anaphase onset, GTSE1 binds preferentially to the most stable mitotic spindle microtubules and promotes their turnover.
Results indicated for the first time that overexpression of GTSE1 was involved in the progress of HCC, enhancing proliferation and promoting cell invasion in HCC cells.
GTSE1 inhibition of MCAK activity regulates the balance of MT stability that determines the fidelity of chromosome alignment, segregation, and chromosomal stability.
Study identifies GTSE1 as a biomarker for cisplatin resistance in gastric cancer cells and suggests its repressive role in cisplatin induced apoptosis making it a potential therapeutic target for better clinical management of gastric cancer patients.
GTSE1 is a microtubule plus-end tracking protein that regulates EB1-dependent cell migration.
GTSE1 is overexpressed dramatically in lung cancer patients' tissues.
Data show that G2 and S-phase-expressed 1 (GTSE1) protein, a negative regulator of p53, is required for G2 checkpoint recovery and that Plk1 phosphorylation of GTSE1 promotes its nuclear localization.
hGTSE-1 mediated-p21(CIP1/WAF1) stabilization is clearly involved in the ability of cells to counteract cytotoxicity induced by the microtubule poison paclitaxel.
GTSE-1 controls DNA damage-induced apoptosis by affecting p53 function
requires an intact nuclear export signal and functional Mdm2 for the regulation of p53
The protein encoded by this gene is only expressed in the S and G2 phases of the cell cycle, where it colocalizes with cytoplasmic tubulin and microtubules. In response to DNA damage, the encoded protein accumulates in the nucleus and binds the tumor suppressor protein p53, shuttling it out of the nucleus and repressing its ability to induce apoptosis.
G-2 and S-phase expressed 1
, G2 and S phase-expressed protein 1
, G2 and S phase-expressed protein 1-like
, g2 and S phase-expressed protein 1-like
, protein B99 homolog
, G two S phase expressed protein 1