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GPN1 encodes a guanosine triphosphatase enzyme. Additionally we are shipping GPN1 Antibodies (54) and many more products for this protein.
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Results show that Gpn1-inhibitable, nuclear polyubiquitination on lysine 216 regulates the half-life of Gpn3 by tagging it for proteasomal degradation.
an acquired PDZ-binding motif in Gpn3 Q279* caused Gpn3 nuclear entry, and inhibited Gpn1 nuclear export and Gpn3-mediated RNAPII nuclear targeting.
GPN1 gene variation is associated with oral cavity and pharyngeal cancer.
Gpn1-Gpn3 interaction was essential to maintain steady-state protein levels of both GTPases
A highly active, evolutionarily conserved nuclear export sequences in XAB1/Gpn1, was identified.
Data show that GPN1/GPN3 define a new family of small GTPases that are specialized for the transport of RNA polymerase II into the nucleus.
RPAP4/GPN1 is a member of a newly discovered GTPase (show RACGAP1 Proteins) family that contains a highly conserved GPN loop motif that is essential, along with its GTP-binding (show RND2 Proteins) motifs, for nuclear localization of POLR2A/RPB1 (show POLR2A Proteins) in a process that also requires microtubule assembly
relieves MBD2 (show DPEP2 Proteins)-mediated transcriptional repression and reactivates transcription from methylated promoters
This gene encodes a guanosine triphosphatase enzyme. The encoded protein may play a role in DNA repair and may function in activation of transcription. Alternatively spliced transcript variants have been described.
, MBD2-interacting protein
, RNA polymerase II associated protein 4
, XPA binding protein 1, GTPase
, XPA binding protein 1
, GPN-loop GTPase 1
, XPA-binding protein 1
, methyl-CpG binding domain protein 2 interacting protein