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GTPBP1 is upregulated by interferon-gamma and encodes a protein that is a member of the AGP11/GTPBP1 family of GTP-binding proteins. Additionally we are shipping GTP Binding Protein 1 Antibodies (49) and GTP Binding Protein 1 Proteins (7) and many more products for this protein.
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Results show that GBP1 (show GBP1 ELISA Kits) is overexpressed in triple-negative breast cancer (TNBC), under the control of EGFR (show EGFR ELISA Kits) and selectively affects the growth of TNBC cell lines.
These findings confirm the involvement of caspase-1 (show CASP1 ELISA Kits) in non-classical secretion mechanisms and open novel perspectives for the extracellular function of secreted GBP-1 (show GBP1 ELISA Kits).
Taken together, these results provide a new understanding of the antiviral mechanism of human GBP1 (show GBP1 ELISA Kits), which possesses potent anti-Kaposi's sarcoma-associated herpesvirus activity, and suggest the critical role of viral RTA (show RBM9 ELISA Kits) in the evasion of the innate immune response during primary infection by Kaposi's sarcoma-associated herpesvirus.
Elevated hGBP-1 RNA in ovarian tumors correlates with shorter recurrence-free survival. hGBP-1 does not confer paclitaxel resistance on MCF-7 and TMX2-28 breast cancer cells.
In insulitic islets from living patients with recent-onset T1D, most of the overexpressed ISGs, including GBP1 (show GBP1 ELISA Kits), TLR3 (show TLR3 ELISA Kits), OAS1 (show OAS1 ELISA Kits), EIF2AK2 (show EIF2AK2 ELISA Kits), HLA-E (show HLAE ELISA Kits), IFI6 (show IFI6 ELISA Kits), and STAT1 (show STAT1 ELISA Kits), showed higher expression in the islet core compared with the peri (show PLIN1 ELISA Kits)-islet area containing the surrounding immune cells
the study not only highlights the importance of hGBP1 tetramer in stimulated GMP (show NT5C2 ELISA Kits) formation, but also demonstrates its role in the antiviral activity against hepatitis C virus.
GBP1 (show GBP1 ELISA Kits) expression is elevated in human Glioblastoma multiforme tumors and positively correlates with EGFRvIII status in Glioblastoma multiforme specimens, and its expression is inversely correlated with the survival rate of Glioblastoma multiforme patients. Taken together, these results reveal that GBP1 (show GBP1 ELISA Kits) may serve as a potential therapeutic target for Glioblastoma multiforme with EGFRvIII mutation.
GBP1 (show GBP1 ELISA Kits) promotes lymph node metastasis and has a positive correlation with EGFR (show EGFR ELISA Kits) expression in esophageal squamous cell carcinoma.
Molecular dynamics studies showed that only GTP (show AK3 ELISA Kits) decreases the formation of the GBP1 (show GBP1 ELISA Kits):PIM1 (show PIM1 ELISA Kits) complex through an allosteric mechanism, outlining the rational for the identification of new compounds potentially able to revert resistance to paclitaxel.
GBP1 (show GBP1 ELISA Kits) overexpression is necessary for the radioresistant phenotype in clinically relevant radioresistant cells
Guanylate binding protein expression is induced by interferon. Guanylate binding proteins are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP) and are distinguished from the GTP-binding proteins by the presence of 2 binding motifs rather than 3.
, GTP-binding protein 1
, GTP binding protein 1
, GTP-binding protein 1-like
, guanine nucleotide-binding protein 1
, guanylate binding protein 1, interferon-inducible, 67kDa
, interferon-induced guanylate-binding protein 1