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Guanylate-binding proteins, such as GBP4, are induced by interferon and hydrolyze GTP to both GDP and GMP (Vestal, 2005 [PubMed 16108726]).[supplied by OMIM, Dec 2008].. Additionally we are shipping GTPBP4 Proteins (5) and GTPBP4 Kits (3) and many more products for this protein.
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GTPBP4 promotes colorectal cancer metastasis by disrupting actin cytoskeleton, which is mediated by the reduced RhoA (show RHOA Antibodies) activity.Up-regulation of GTPBP4 in colorectal carcinoma is responsible for tumor metastasis.
NGB is a tumor suppressor that regulates and requires merlin (show NF2 Antibodies) to suppress cell proliferation
These results suggest that conformational changes in the switch II element of Nog1 (show NOG Antibodies) have a critical importance for the dissociation of preribosome-bound factors during intranucleolar maturation.
Resonance Raman spectroscopy was used to determine the structure of the heme environment in Ngb (show NGB Antibodies) from mice.
GTP-binding proteins are GTPases and function as molecular switches that can flip between two states: active, when GTP is bound, and inactive, when GDP is bound. 'Active' in this context usually means that the molecule acts as a signal to trigger other events in the cell. When an extracellular ligand binds to a G-protein-linked receptor, the receptor changes its conformation and switches on the trimeric G proteins that associate with it by causing them to eject their GDP and replace it with GTP. The switch is turned off when the G protein hydrolyzes its own bound GTP, converting it back to GDP. But before that occurs, the active protein has an opportunity to diffuse away from the receptor and deliver its message for a prolonged period to its downstream target.
G protein-binding protein CRFG
, GTP-binding protein NGB
, chronic renal failure gene protein
, nucleolar GTP-binding protein 1
, GTP binding protein 3
, Nucleolar GTP-binding protein 1 (Chronic renal failure gene protein) (GTP-binding protein NGB)
, chronic renal failure protein
, GTP binding protein NGB
, GTP binding protein 4
, GTP-binding protein