the present findings reveal that High-altitude polycythemia -induced gastric mucosal lesion inspires the protection responses by up-regulating APOA4 (show APOA4 ELISA Kits) and APOC3 (show APOC3 ELISA Kits), and down-regulating GIF.
study reports that FUT2 secretor variant influences GIF secretion in B12 deficient cases bearing GIF heterozygous mutations, in absence of H. pylori related gastritis
Our genetic screening of 154 families of patients with inherited cobalamin malabsorption revealed population-specific mutations, mutational hotspots, and functionally distinct regions in the three causal genes: CUBN (show CUBN ELISA Kits), AMN (show ABCD1 ELISA Kits), and GIF.
Acute lymphoblastic leukemia and vitamin B12 deficiency secondary to a gastric intrinsic factor gene mutation
crystal structure of the complex between IF-Cbl and the cubilin IF-Cbl-binding-region (CUB(5-8)) determined at 3.3 A resolution
A polymorphism in the gastric intrinsic factor gene is associated with congenital intrinsic factor deficiency.
The parameters obtained for ligand and receptor binding in this study indicate that both full-length 50-kDA intrinsic factor and its 30-kDa and 20-kDa fragments may be involved in assimilation of cobalamin.
The Q5R mutation of the intrinsic factor gene predisposes to adult-onset pernicious anemia & other causes of low vitamin B12. In this mutation, intrinsic factor secretion is preserved but B12 absorption may be impaired.
a specific GIF mutation to be responsible for all Juvenile cobalamin deficiency cases of West-African origin so far was identified
Spasmolytic polypeptide (show TFF2 ELISA Kits)/trefoil (show TFF3 ELISA Kits) factor family 2 (TFF2 (show TFF2 ELISA Kits))-expressing metaplasia (SPEM)was immunoreactive for TFF2 (show TFF2 ELISA Kits), Mist1 and intrinsic factor, suggesting that SPEM derived from transdifferentiation of chief cells.
binds vitamin B12 (cobalamin)
gastric intrinsic factor (vitamin B synthesis) , gastric intrinsic factor , IF , INF , intrinsic factor , pancreatic intrinsic factor , gastric intrinsic factor-like
GENE ID | SPECIES |
---|---|
698704 | Macaca mulatta |
770547 | Gallus gallus |
451215 | Pan troglodytes |
100060988 | Equus caballus |
616252 | Bos taurus |
449477 | Canis lupus familiaris |
2694 | Homo sapiens |
100460421 | Pongo abelii |
100514273 | Sus scrofa |
100583542 | Nomascus leucogenys |
14603 | Mus musculus |
100356172 | Oryctolagus cuniculus |
29319 | Rattus norvegicus |
100726366 | Cavia porcellus |