anti-Gastrin (GAST) Antibodies

Human Gastrin (GAST) interaction partners

1. Gastrin and BCL2 (show BCL2 Antibodies) apoptosis regulator (Bcl2 (show BCL2 Antibodies)) are highly expressed in gastric cancer tissues, and they are correlated with the clinicopathologic features.

2. Everolimus down-regulates the systemic levels of gastrin and glucagon (show GCG Antibodies) in patients with pancreatic neuroendocrine tumors.

3. we suggest that gastrin contributes to the emergence of MDR of SGC7901 cells via the degradation of p27Kip1 (show CDKN1B Antibodies)

4. Results demonstrate that gastrin increases the expression of the autophagy markers MAP1LC3B (show MAP1LC3B Antibodies)-II and SQSTM1 (show SQSTM1 Antibodies) in gastric adenocarcinoma cells. Gastrin induces autophagy via activation of the STK11 (show STK11 Antibodies)-PRKAA2 (show PRKAA2 Antibodies)-ULK1 (show ULK1 Antibodies) and that this signaling pathway is involved in increased migration and cell survival.

5. PTHLH is a gastrin-regulated growth factor that might contribute to gastric epithelial cell homeostasis.

6. Gastrin is expressed in both in (show INS Antibodies)sulin(+) and somatostatin(+) cells in adults with type 2 diabetes.

7. Gastrin induced ABCG2 expression by activating NF-kappaB (show NFKB1 Antibodies) and thereby modulated the side population proportion, tumor cell metastatic potential and invasion activity in pancreatic cancer.

8. CTGF (show CTGF Antibodies) is overexpressed in gastric cancer and adjacent tissue compared to normal gastric tissue. Gastrin induces expression of CTGF (show CTGF Antibodies) in gastric epithelial cells.

9. Data show that 6 of 20 primary pancreatic neuroendocrine tumors (PNETs) had positive staining for multiple hormones gastrin, insulin (show INS Antibodies), glucagon (show GCG Antibodies), and somatostatin (show SST Antibodies), and positive expression of 1 or more hormones was found in 9 of 12 nonfunctioning PNETs [NF-PNETs]) patients.

10. Gastrin role in gastric epithelial homeostasis and gastric carcinogenesis

Mouse (Murine) Gastrin (GAST) interaction partners

1. Gastrin induces nuclear export and proteasome degradation of menin in duodenal glial cells.

2. PTHLH is a gastrin-regulated growth factor that might contribute to gastric epithelial cell homeostasis.

3. Renal-selective silencing of Gast by the renal subcapsular injection of Gast siRNA in BALB/c mice decreases renal dopamine production and increases blood pressure.

4. Gastrin is expressed in insulin (show INS Antibodies) secreting cells of adult diabetic mice.

5. CTGF (show CTGF Antibodies) is overexpressed in gastric cancer and adjacent tissue compared to normal gastric tissue. Gastrin induces expression of CTGF (show CTGF Antibodies) in gastric epithelial cells.

6. Ihh (show IHH Antibodies) signaling mediates gastrin-induced proliferation of epithelial cells in stomachs of adult mice.

7. mouse corneal afferent sensory neurons expressed CCK (show CCK Antibodies) and GAST, and the CCK1R (show CCKAR Antibodies) receptors.

8. Data indicate that epithelial Gli2 (show GLI2 Antibodies) expression was sufficient to stimulate Il-1beta (show IL1B Antibodies) expression, repress Gast gene expression and increase proliferation, leading to antral hyperplasia.

9. Initiation of antral gastric cancer is associated with progressive epigenetic silencing of TFF1 (show TFF1 Antibodies), which can be suppressed by the hormone gastrin.

10. Regulation of mouse gastrin gene in vivo. Mechanisms involved in transcriptional control of the gastrin gene.

Guinea Pig Gastrin (GAST) interaction partners

1. Serum gastrin decreased significantly in the cholesterol gallstone groups compared to the control group.