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The protein encoded by GKN1 is found to be down-regulated in human gastric cancer tissue as compared to normal gastric mucosa. Additionally we are shipping Gastrokine 1 Antibodies (107) and Gastrokine 1 Kits (41) and many more products for this protein.
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Human Gastrokine 1 Protein expressed in Wheat germ - ABIN1355172
Fahlbusch, Ruebner, Huebner, Volkert, Zuern, Thiel, Koch, Menendez-Castro, Wachter, Hartner, Rascher: The tumor suppressor gastrokine-1 is expressed in placenta and contributes to the regulation of trophoblast migration. in Placenta 2013
Data show that ubiquitin protein ligase E3 component n-recognin 5 protein (UBR5) bound the tumor suppressor gastrokine 1 (GKN1) and increased its ubiquitination to reduce the protein stability of GKN1.
These results did not confirm GKN1 as a potential biomarker for gastric cancer.
Low GKN1 expression is associated with gastric cancer.
GKN1 may contribute to the maintenance of gastric epithelial homeostasis and inhibit gastric carcinogenesis by down-regulating the gastrin-cholecystokinin B receptor (show CCKBR Proteins) signaling pathway.
Gastrokine 1 indirectly participates in actin stabilization since its overexpression in gastric cancer cells strongly increases the expression of tight and adherens junction proteins
AMP-18 appears to act through PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) pathways to increase p21 (show CDKN1A Proteins) phosphorylation, thereby reducing its nuclear accumulation to overcome the antiproliferative effects of TNF-alpha (show TNF Proteins).
Results suggest a potential association between CRP and GPC5 variants with lung cancer risk; variation in GKN1 is associated with chemotherapy response in the Chinese Han population.
GKN1 inhibits metastasis in gastric cancer cells.
GKN1 may shorten telomeres by acting as a potential c-myc (show MYC Proteins) inhibitor that eventually leads to senescence and apoptosis in gastric cancer cells
GKN1 expression in the gastric mucosa of gastric cancer patients is decreased; this is associated with progression and prognosis of gastric cancer.
The protein encoded by this gene is found to be down-regulated in human gastric cancer tissue as compared to normal gastric mucosa.
, 18 kDa antrum mucosa protein
, protein CA11 homolog
, BRICHOS domain containing 1