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Accurate transcription initiation on TATA-containing class II genes involves the ordered assembly of RNA polymerase II (POLR2A\; MIM 180660) and several general initiation factors (summarized by DeJong and Roeder, 1993 [PubMed 8224848]).
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TFIIA is the principal TASP1 substrate that orchestrates craniofacial morphogenesis.
In a cohort of youth at risk for bipolar disorder, pathway analysis showed an enrichment of the glucocorticoid receptor (GR (show NR3C1 ELISA Kits)) pathway with the genes MED1 (show MED1 ELISA Kits), HSPA1L (show HSPA1L ELISA Kits), GTF2A1 and TAF15, which might underlie the previously reported role of stress response in the risk for bipolar disorder in vulnerable populations.
Data suggest that many TATA-box-containing promoters contain a TFIIA recognition element (IIARE) that activates transcription by increasing the recruitment of RNA polymerase II, TFIIA (TF2A1/TF2A2 subunits), TAF4 (show TAF4 ELISA Kits), and P300 (show EP300 ELISA Kits). (TAF4 (show TAF4 ELISA Kits) = TATA box binding protein (TBP (show TBP ELISA Kits))-associated factor, RNA polymerase II, C1; P300 (show EP300 ELISA Kits) = E1A binding protein p300 (show EP300 ELISA Kits))
The interaction of TBP (show TBP ELISA Kits)-like protein with TFIIA is essential to suppress proteasome-dependent turnover of TBP (show TBP ELISA Kits)-like protein
Our results provide first evidence that Taspase1 processing affects TFIIA regulation of TFIID and suggest that Taspase1 processing of TFIIA is required to establish INR-selective core promoter activity in the presence of NC2.
spatial positioning of the DNA-bound activation domain is important for efficient activation, possibly by maximizing its interactions with the transcriptional machinery including the TBP (show TBP ELISA Kits)-TFIIA-TFIIB (show GTF2B ELISA Kits)-promoter quaternary complex
Results present the X-ray structures of human and yeast TATA box-binding protein /transcription factor IIA/DNA complexes at 2.1A and 1.9A resolution, respectively
transcription factor IIA may regulate the intracellular molecular state and the function of TATA-binding protein-like protein (TLP) through its property of binding to TLP
Transfected taspase 1 enhances cleavage of TFIIA, and RNA interference knockdown of endogenous taspase 1 diminishes cleavage of TFIIA in vivo.
TFIIA induces a conformational change within the TBP (show TBP ELISA Kits)/TATA complex that enhances its stability under both in vitro and physiological salt conditions.
GTF2A1 alone, or GTF2A1 plus HAAO (show HAAO ELISA Kits) are excellent candidate biomarkers for detecting Ovarian cancer
Accurate transcription initiation on TATA-containing class II genes involves the ordered assembly of RNA polymerase II (POLR2A\; MIM 180660) and several general initiation factors (summarized by DeJong and Roeder, 1993
general transcription facter IIA subunit 1 variant 1
, transcription initiation factor IIA subunit 1
, transcription factor IIA large subunit-2
, general transcription factor IIA, 1, 19/37kDa
, TFIIA alpha, p55
, transcription factor IIA large subunit-1
, TFIIA alpha/beta
, general transcription factor IIA subunit 1
, general transcription factor IIa, 1 (37kD and 19kD subunits)
, TFIIA large subunit
, general transcription factor 2a, 1
, glucose regulated protein, 58kD pseudogene
, transcription initiation factor TFIIA 42 kDa subunit