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GTF2B encodes the general transcription factor IIB, one of the ubiquitous factors required for transcription initiation by RNA polymerase II. Additionally we are shipping General Transcription Factor IIB Antibodies (120) and General Transcription Factor IIB Kits (20) and many more products for this protein.
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binding of specific DNA sequences changes the protein structure and dynamics, and TFIIB may exist in two conformational states
The role of zinc at Cys3His1 binding site in the absence of TFIIB protein folding
these results establish a new paradigm for TFIIB functionality in human gene expression, which when downregulated has potent anti-viral effects.
Association of the winged helix motif of the TFIIEalpha subunit of TFIIE with either the TFIIEbeta subunit or TFIIB distinguishes its functions in transcription.
TFIIB was involved in the proliferation and growth of HCC (show FAM126A Proteins) cells.
a mode of phospho-TFIIB-independent transcriptional regulation that prioritizes the transcription of p53 (show TP53 Proteins)-target genes during cellular stress.
Data show that TFIIF (show GTF2F1 Proteins) has an important role in stabilizing TFIIB within the PIC and after transcription initiates.
a six-amino acid human TFIIB tip region is needed for appropriate levels of serine 5 C-terminal domain phosphorylation and mRNA capping and for retention of the required elongation factor (show TSFM Proteins) TFIIF (show GTF2F1 Proteins).
phosphorylation of TFIIB at serine 65 is a critical event in transcription that links the gene promoter and terminator and triggers initiation by RNA pol II
interaction with vitamin D receptor (show VDR Proteins) helix H10 (show H1F0 Proteins) residues
by acutely targeting TFIIB, we were able to inhibit selectively the former set of genes and ameliorate pressure overload hypertrophy.
TFIIB co-localizes and interacts with alpha-tubulin (show TUBA4A Proteins) during oocyte meiosis in the mouse and depletion of TFIIB causes arrest of subsequent embryo development.
Study suggest that components of the transcription machinery decreased in accordance with cell differentiation and that TFIIB is specifically and rapidly degraded by the ubiquitin-proteasome pathway.
This gene encodes the general transcription factor IIB, one of the ubiquitous factors required for transcription initiation by RNA polymerase II. The protein localizes to the nucleus where it forms a complex (the DAB complex) with transcription factors IID and IIA. Transcription factor IIB serves as a bridge between IID, the factor which initially recognizes the promoter sequence, and RNA polymerase II.
, transcription factor IIB
, transcription initiation factor iib
, transcription initiation factor IIB
, transcription initiation factor iiB
, Transcription initiation factor IIB
, hypothetical protein
, general transcription factor IIB
, general transcription factor TFIIB
, RNA polymerase II transcription factor IIB
, RNA polymerase II alpha initiation factor