General Transcription Factor IIB Proteins (GTF2B)

GTF2B encodes the general transcription factor IIB, one of the ubiquitous factors required for transcription initiation by RNA polymerase II. Additionally we are shipping General Transcription Factor IIB Antibodies (115) and General Transcription Factor IIB Kits (29) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GTF2B 2959 Q00403
GTF2B 229906 P62915
GTF2B 81673 P62916
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Top General Transcription Factor IIB Proteins at antibodies-online.com

Showing 10 out of 18 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 50 Days
$6,749.58
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 50 Days
$6,749.58
Details
Escherichia coli (E. coli) Human GST tag   50 μg 4 Days
$522.50
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Escherichia coli (E. coli) Human His tag 100 μg 15 to 19 Days
$519.23
Details
Escherichia coli (E. coli) Human His tag Validation with Western Blot 10 μg 4 to 8 Days
$394.90
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
$888.80
Details
Wheat germ Human GST tag 10 μg 11 to 12 Days
$340.00
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Yeast Rice His tag   1 mg 60 to 71 Days
$2,834.33
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Yeast Xenopus laevis His tag   1 mg 60 to 71 Days
$2,847.17
Details
Yeast Rat His tag   1 mg 60 to 71 Days
$2,847.17
Details

GTF2B Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, , , ,
Mouse (Murine)

Rat (Rattus)

More Proteins for General Transcription Factor IIB (GTF2B) Interaction Partners

Human General Transcription Factor IIB (GTF2B) interaction partners

  1. a hand-off model in which Ssu72 mediates a conformational transition in TFIIB, accounting for the role of Ssu72 in transcription reinitiation, gene looping, and promoter-terminator cross-talk.

  2. binding of specific DNA sequences changes the protein structure and dynamics, and TFIIB may exist in two conformational states

  3. The role of zinc at Cys3His1 binding site in the absence of TFIIB protein folding

  4. these results establish a new paradigm for TFIIB functionality in human gene expression, which when downregulated has potent anti-viral effects.

  5. Association of the winged helix motif of the TFIIEalpha subunit of TFIIE with either the TFIIEbeta subunit or TFIIB distinguishes its functions in transcription.

  6. TFIIB was involved in the proliferation and growth of HCC cells.

  7. a mode of phospho-TFIIB-independent transcriptional regulation that prioritizes the transcription of p53-target genes during cellular stress.

  8. Data show that TFIIF has an important role in stabilizing TFIIB within the PIC and after transcription initiates.

  9. a six-amino acid human TFIIB tip region is needed for appropriate levels of serine 5 C-terminal domain phosphorylation and mRNA capping and for retention of the required elongation factor TFIIF.

  10. phosphorylation of TFIIB at serine 65 is a critical event in transcription that links the gene promoter and terminator and triggers initiation by RNA pol II

  11. interaction with vitamin D receptor helix H10 residues

  12. Data show that human TATA box binding protein (TBP) can use a shared surface to interact with two different transcription factor IIB (TFIIB) family members to initiate transcription by different RNA polymerases.

  13. The groove in the first cyclin repeat of TFIIB is identified as the FCP1-binding site of TFIIB core domain (TFIIBc), consisting of several hydrophobic and several basic amino acids.

  14. lack of role in bending of TATA-binding protein simultaneously with promotoer DNA

  15. TFIIB interacts with SP1/SP3 at the SP1 site, besides its association with EAR3 and the TATA-less core promoter region.

  16. in addition to its role in regulating TBP binding to a TATA box, the TBP surface is unexpectedly involved in TBP association with all three TFIIB family members

  17. The structural role of Zn2+ binding to the the zinc-ribbon domain of TFIIB was analysed.

  18. Results identify a small nonconserved surface of the transcription factor TFIIB zinc ribbon that is required for RNA polymerase II (pol II) transcription in vivo and for different types of basal pol II transcription in vitro.

  19. A TFIIB conformational change is critical for the formation of activator-dependent transcription complexes.

  20. Collapse of the transcription bubble defines the RNA polymerase II promoter clearance transition.

Mouse (Murine) General Transcription Factor IIB (GTF2B) interaction partners

  1. by acutely targeting TFIIB, we were able to inhibit selectively the former set of genes and ameliorate pressure overload hypertrophy.

  2. TFIIB co-localizes and interacts with alpha-tubulin during oocyte meiosis in the mouse and depletion of TFIIB causes arrest of subsequent embryo development.

  3. Study suggest that components of the transcription machinery decreased in accordance with cell differentiation and that TFIIB is specifically and rapidly degraded by the ubiquitin-proteasome pathway.

General Transcription Factor IIB (GTF2B) Protein Profile

Protein Summary

This gene encodes the general transcription factor IIB, one of the ubiquitous factors required for transcription initiation by RNA polymerase II. The protein localizes to the nucleus where it forms a complex (the DAB complex) with transcription factors IID and IIA. Transcription factor IIB serves as a bridge between IID, the factor which initially recognizes the promoter sequence, and RNA polymerase II.

Gene names and symbols associated with GTF2B

  • Transcription factor IIB (TfIIB)
  • transcription initiation factor iib (CNF01950)
  • transcription initiation factor IIB (tfb)
  • transcription initiation factor IIB (CC1G_14689)
  • transcription initiation factor IIB (HacjB3_18813)
  • transcription initiation factor IIB 2 (HALXA_RS07110)
  • transcription initiation factor IIB 2 (HALXA_RS16310)
  • Transcription initiation factor IIB (tf2b)
  • transcription initiation factor IIB (LOC100283348)
  • general transcription factor 2B S homeolog (gtf2b.S)
  • general transcription factor 2B L homeolog (gtf2b.L)
  • general transcription factor IIB (GTF2B)
  • general transcription factor IIB (gtf2b)
  • general transcription factor IIB (Gtf2b)
  • CG5193 protein
  • Dmel\\CG5193 protein
  • dmTFIIB protein
  • dTfIIB protein
  • gtf2b protein
  • TF2B protein
  • tfiib protein
  • TfllB protein
  • wu:fc44c11 protein
  • XLTFIIB protein
  • zgc:66258 protein

Protein level used designations for GTF2B

CG5193-PA , CG5193-PB , TfIIB-PA , TfIIB-PB , transcription factor IIB , transcription initiation factor iib , transcription initiation factor IIB , transcription initiation factor iiB , Transcription initiation factor IIB , GRMZM2G002828 , hypothetical protein , general transcription factor IIB , general transcription factor TFIIB , RNA polymerase II transcription factor IIB , S300-II , RNA polymerase II alpha initiation factor

GENE ID SPECIES
34430 Drosophila melanogaster
3258410 Cryptococcus neoformans var. neoformans JEC21
9166208 Thermosphaera aggregans DSM 11486
9378258 Coprinopsis cinerea okayama7130
9421549 Halalkalicoccus jeotgali B3
10278802 Methanobacterium sp. AL-21
10395005 Archaeoglobus veneficus SNP6
10772858 Methanothermococcus okinawensis IH1
10797085 Halopiger xanaduensis SH-6
10798947 Halopiger xanaduensis SH-6
100196268 Salmo salar
100283348 Zea mays
494830 Xenopus laevis
394390 Xenopus laevis
2959 Homo sapiens
324823 Danio rerio
479960 Canis lupus familiaris
513231 Bos taurus
229906 Mus musculus
81673 Rattus norvegicus
100359058 Oryctolagus cuniculus
100732994 Cavia porcellus
100155974 Sus scrofa
424518 Gallus gallus
101119003 Ovis aries
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