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Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Additionally we are shipping General Transcription Factor IIE, Polypeptide 2 Proteins (8) and many more products for this protein.
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Human Polyclonal GTF2E2 Primary Antibody for ICC, IF - ABIN4358742
Kuschal, Botta, Orioli, Digiovanna, Seneca, Keymolen, Tamura, Heller, Khan, Caligiuri, Lanzafame, Nardo, Ricotti, Peverali, Stephens, Zhao, Lehmann, Baranello, Levens, Kraemer, Stefanini: GTF2E2 Mutations Destabilize the General Transcription Factor Complex TFIIE in Individuals with DNA Repair-Proficient Trichothiodystrophy. in American journal of human genetics 2016
functional analysis of Trichothiodystrophy causative TFIIEbeta mutation demonstrates that mutant TFIIEbeta strongly reduces the total amount of the entire TFIIE complex, with a remarkable temperature-sensitive transcription defect.
The N-terminal half of TFIIEalpha forms an extended winged helix (WH) domain with an additional helix, followed by a zinc-finger domain. TFIIEbeta contains the WH2 domain, followed by two coiled-coil helices intertwining with TFIIEalpha.
We underline role of TFIIE in transcription and its distinction from nucleotide excision repair. Trichothiodystrophy individuals with mutations in GTF2E2 highlight the importance of the direct interaction between TFIIH and TFIIE in transcription process.
PC4 plays essential roles in the transition step from transcription initiation to elongation by binding to melted DNA in collaboration with TFIIEbeta.
introduced point mutations into two regions located near the carboxy terminus of TFIIE beta and identified the functionally essential amino acid residues that bind to RNA polymerase II
TFIIE is an alpha/beta heterodimer in solution; A model for the quaternary architecture of the complex is proposed that provides a structural framework to discuss the function of TFIIE in the context of RNA polymerase II transcription initiation.
These data suggest a model in which TFIIE binds to a position adjacent to the initiation site via the forkhead domain, enabling TFIIH to begin opening the promoter.
Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.
, general transcription factor II E, polypeptide 2 (beta subunit, 34kD)
, general transcription factor IIE subunit 2
, general transcription factor IIE, polypeptide 2 (beta subunit, 34kD)
, transcription initiation factor IIE subunit beta
, general transcription factor II E, polypeptide 2 (beta subunit)
, general transcription factor IIE, polypeptide 2 (beta subunit)