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TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB.
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These results suggest that Mediator structural shifts induced by activator binding help stably orient pol II prior to transcription initiation within the human mediator-RNA polymerase II-TFIIF assembly.
Gdown1 competes with TFIIF for binding to the RPB1 and RPB5 subunits of Pol II, thereby inhibiting an essential function of TFIIF in preinitiation complex assembly.
Data show that TFIIF has an important role in stabilizing TFIIB (show GTF2B ELISA Kits) within the PIC and after transcription initiates.
role of associated carboxyl-terminal domain phosphatase in dephosphorylating phosphoserines 2 and 5 of RNA polymerase II
The alpha 1 helix of human RAP74 has an important role in the initiation and elongation of RNA chains
The NMR solution structure of the C-terminal domain of RAP74 has been determined, and NMR methods have been used to map the binding sites of the C-terminus of CTD phosphatase/FCP1 (show CTDP1 ELISA Kits) on the RAP74 C-terminal fragment.
cocrystal structure of the winged-helix domain of human RNA polymerase II-associating protein 74 bound to the alpha-helical C terminus of human FCP1 (show CTDP1 ELISA Kits)
NMR structure of a complex containing this TFIIF subunit and the RNA polymerase II carboxyl-terminal domain phosphatase FCP1 (show CTDP1 ELISA Kits).
Interaction of TFIIF subunit RAP74 with recombinant androgen receptor (show AR ELISA Kits) N-terminal activation domain AF1 (show EFNA5 ELISA Kits) leads to imposition of helical structure on the AF1 (show EFNA5 ELISA Kits) domain.
TFIIF supports elongation and suppresses pausing by stabilizing the post-translocated elongation complex
TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation.
, general transcription factor IIF 74 kDa subunit
, general transcription factor IIF subunit 1
, transcription initiation factor IIF subunit alpha
, transcription initiation factor RAP74
, general transcription factor IIF, polypeptide 1, 74kDa
, transcription initiation factor IIF alpha subunit
, general transcription factor IIF polypeptide 1 (74kD subunit)
, RAP74 subunit of transcription factor IIF