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Serine/threonine-protein kinase that phosphorylates histone H3 at 'Ser-3' (H3T3ph) during mitosis. Additionally we are shipping Germ Cell Associated 2 (Haspin) Proteins (7) and Germ Cell Associated 2 (Haspin) Kits (4) and many more products for this protein.
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Human Polyclonal GSG2 Primary Antibody for IHC (p), WB - ABIN1882168
Dai, Sultan, Taylor, Higgins: The kinase haspin is required for mitotic histone H3 Thr 3 phosphorylation and normal metaphase chromosome alignment. in Genes & development 2005
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Human Polyclonal GSG2 Primary Antibody for WB - ABIN949715
Wang, Wei, Du, Cao, Zhang, Liu, Liu, Chen, Ma: H3 Thr3 phosphorylation is crucial for meiotic resumption and anaphase onset in oocyte meiosis. in Cell cycle (Georgetown, Tex.) 2016
The mitotic histone kinase Haspin binds to the cohesin regulatory subunit Pds5B through a conserved YGA/R motif in its non-catalytic N terminus, which is similar to the recently reported YSR-motif-dependent binding of Wapl to Pds5B.
The authors' data identify the HIM of Pds5 as a binding motif for Haspin/Hrk1 (show KCNJ4 Antibodies) in fission yeast. The authors' analyses also show that human PDS5B (show PDS5B Antibodies) binds Haspin through the same HIM-PIM (show PIM1 Antibodies) interaction module, indicating that the Haspin localization mechanism is highly conserved.
Autosomal recessive RP associated with mutations in the male germ cell-associated kinase (MAK (show MAK Antibodies)) gene is associated with preservation of foveal vision even in advanced stages of retinal degeneration despite similar rates of peripheral visual field loss to other forms of autosomal recessive RP
This is the first structural model of a bisubstrate inhibitor targeting haspin. The presented structural data represent a model for the future development of more specific haspin inhibitors
Haspin kinase plays a key role in maintaining the slowly exchanging centromere Borealin (show CDCA8 Antibodies) pool.
Haspin activity affects the phosphorylation state of proteins involved in gene expression regulation and splicing.
Haspin inhibitors reveal centromeric roles of Aurora B (show AURKB Antibodies) in chromosome movement and spindle checkpoint signaling
Aurora B (show AURKB Antibodies) phosphorylates Haspin to promote generation of H3T3ph and that Aurora B kinase (show AURKB Antibodies) activity is required for normal chromosomal localization of the CPC, indicating an intimate linkage between Aurora B (show AURKB Antibodies) and Haspin functions in mitosis
findings show phosphorylation of histone H3 (show HIST3H3 Antibodies)-threonine 3 mediated by Haspin cooperates with Bub1 (show BUB1 Antibodies)-mediated histone 2A (show HIST3H2A Antibodies)-serine 121 phosphorylation in targeting the chromosomal passenger complex to the inner centromere in fission yeast and human cells
phosphorylation of H3T3 by Haspin is necessary for chromosomal passenger complex(CPC) accumulation at centromeres; Survivin binds to H3T3ph; H3T3ph generated by Haspin positions CPC at centromeres to regulate selected targets of Aurora B (show AURKB Antibodies) during mitosis
These data uncover a role for haspin as a regulator of bipolar spindle assembly by regulating AURKC (show AURKC Antibodies) function at acentriolar microtubule-organizing centers in oocytes.
Data implicate haspin as a regulator of the chromosomal passenger complex and chromosome segregation during meiosis I.
the tissue-dependent and differentially methylated region functions as a modulator in a DNA methylation (show HELLS Antibodies)-dependent manner; Gsg2 is under epigenetic control
the 193-bp DNA sequence in Haspin promotor is sufficient for the specific, bidirectional, and synchronous expression in germ cells in the testis.
Serine/threonine-protein kinase that phosphorylates histone H3 at 'Ser-3' (H3T3ph) during mitosis. This positions and activates AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle (By similarity).
serine/threonine-protein kinase haspin-like protein
, germ cell associated 2 (haspin)
, putative serine/threonine-protein kinase haspin homolog
, germ cell-specific gene 2 protein
, haploid germ cell-specific nuclear protein kinase
, serine/threonine-protein kinase haspin