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GMCL1 encodes a nuclear envelope protein that appears to be involved in spermatogenesis, either directly or by influencing genes that play a more direct role in the process. Additionally we are shipping Germ Cell-Less, Spermatogenesis Associated 1 Proteins (3) and and many more products for this protein.
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Gmcl1 interacts with the DP component of the E2F transcription factor.
the mgcl-1 gene product appears to be essential for appropriate nuclear-lamina organization, which in turn is essential for normal sperm morphogenesis and chromatin remodeling.
mGCL-1 is a factor modulating MDM2-p53 axis by enhanced degradation of MDM2
Dual association of GAGE family members with GCL at the nuclear envelope inner membrane in cells, and with dsDNA in vitro, implicate GAGE proteins in chromatin regulation in germ cells and cancer cells.
Mouse GMCL1 interacts with the DP component of the E2F transcription factor.
GCL binds directly to emerin, and the emerin-repressor complexes might be regulated by barrier to autointegration factor
Germ cell-less protein is not essential for the chromosomal events of meiosis but might be involved in later aspects of spermatogenesis.
These data suggest that zebrafish germ cell-less (gcl) have potentially important roles in the formation of primordial germ cells.
This gene encodes a nuclear envelope protein that appears to be involved in spermatogenesis, either directly or by influencing genes that play a more direct role in the process. This multi-exon locus is the homolog of the mouse and drosophila germ cell-less gene but the human genome also contains a single-exon locus on chromosome 5 that contains an open reading frame capable of encoding a highly-related protein.
, DP-interacting protein
, germ cell-less protein-like 1
, germ cell-less homolog 1
, germ cell-less protein
, spermatogenesis associated 29