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GRWD1 encodes a glutamate-rich protein that contains five WD-repeat motifs. Additionally we are shipping Glutamate-Rich WD Repeat Containing 1 Kits (7) and Glutamate-Rich WD Repeat Containing 1 Proteins (4) and many more products for this protein.
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GRWD1 overexpression in combination with HPV16 E7 and activated KRAS confers anchorage-independent growth and tumorigenic capacity on normal human fibroblasts. Consistent with this, GRWD1 overexpression is associated with poor prognosis in cancer patients.
Cdt1-binding protein GRWD1 promotes chromatin fluidity by influencing nucleosome structures, e.g., by transient eviction of H2A-H2B, and thereby promotes efficient MCM loading at replication origins.
This gene encodes a glutamate-rich protein that contains five WD-repeat motifs. The encoded protein may play a critical role in ribosome biogenesis and may also play a role in histone methylation through interactions with CUL4-DDB1 ubiquitin E3 ligase.
CUL4- and DDB1-associated WDR protein 4
, WD repeat domain 28
, glutamate rich WD repeat protein GRWD
, glutamate-rich WD repeat-containing protein 1
, regulator of ribosome biogenesis 1 homolog