Glutathione Peroxidase (GPX4) ELISA Kits

May constitute a glutathione peroxidase-like protective system against oxidative stresses (By similarity).

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human GPX4 GPX4 2879 P36969
Anti-Rat GPX4 GPX4 29328 P36970 , Q91XR8
Anti-Mouse GPX4 GPX4 625249 O70325 , Q91XR9
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Top GPX4 ELISA Kits at

Showing 4 out of 9 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 1.95 7.8 Typical standard curve 96 Tests Log in to see 15 to 18 Days
Mouse 7.81 pg/mL 31.25-2000 pg/mL Typical standard curve 96 Tests Log in to see 15 to 18 Days
Rat 1.17 4.68 Typical standard curve 96 Tests Log in to see 15 to 18 Days
Human < 2.62 ng/mL 6.25 ng/mL - 100 ng/mL   96 Tests Log in to see 11 to 18 Days

More ELISA Kits for GPX4 Interaction Partners

Human Glutathione Peroxidase (GPX4) interaction partners

  1. Results suggest that single nucleotide polymorphism rs713041 in glutathione peroxidase 4 (GPx4) may play a key role in the pathogenesis of preeclampsia (PE).

  2. Targeting Dependency on the GPX4 Lipid Peroxide Repair Pathway for Cancer Therapy.

  3. The results indicate that the single-nucleotide polymorphism rs713041 in GPX4 gene could modulate the pattern of global gene expression. Supplementation with Brazil nuts can modify the gene expression of some selenoproteins depending upon the presence of genetic polymorphisms.

  4. GPX1, GPX3 and GPX4 may be upregulated in response to a change in oxidative stress during an acute coronary syndromes

  5. The proliferation of GPx4 siRNA-treated cells was downregulated compared with that of control siRNA-treated cells. GPx4 knockdown enhanced hydrogen peroxide- and ferrous sulfate-induced cytotoxicity.

  6. High GPX4 expression is associated with oral squamous cell carcinoma.

  7. By screening peptide libraries displayed on T7 phages, and analyzing the X-ray crystal structures of the peptides, we successfully identified one peptide that binds to near Sec73 of catalytic site and two peptides that bind to another site on GPX4. To our knowledge, this is the first study reporting GPX4 inhibitory peptides and their structural information.

  8. use GPX4 and GPX7 as possible markers for improving HCC diagnosis/prognosis.

  9. One SNP (rs3746162) in GPX4 was significantly associated with bladder cancer recurrence after transurethral resection.

  10. Hepatitis C virus (HCV) induces oxidative stress but controls it tightly by inducing ROS scavengers. Among these, GPx4 plays an essential role in the HCV life cycle.

Zebrafish Glutathione Peroxidase (GPX4) interaction partners

  1. We found that the gpx4b gene shows maternal and zygotic gene expression in the embryo proper compared to gpx4a that showed zygotic gene expression in the periderm covering the yolk cell only.

Mouse (Murine) Glutathione Peroxidase (GPX4) interaction partners

  1. Gpx4 was dispensable for the maintenance of cellular health and function of POMC (show POMC ELISA Kits) neurons, even in mice exposed to obesogenic conditions. In contrast, HFHS-fed mice with Gpx4 deletion from AgRP (show AGRP ELISA Kits) neurons displayed increased body adiposity. Gpx4 deletion from dopaminergic neurons induced anxiety behavior, and diminished spontaneous locomotor activity when DJ-1 (show PARK7 ELISA Kits) was co-deleted.

  2. After tamoxifen treatment to ablate Gpx4, Gpx4BIKO mice developed impairment in hippocampus dependent spatial learning and memory function which was associated with neurodegeneration. Consistent with its role as a regulator of ferroptosis, cognitive impairment and neurodegeneration in Gpx4BIKO mice was associated with elevated lipid peroxidation, ERK(1 (show MAPK3 ELISA Kits)/2) activation and overt neuroinflammation.

  3. The structure of the cytoplasmic isoform of mouse phospholipid hydroperoxide glutathione peroxidase (O70325-2 GPx4) with selenocysteine 46 mutated to cysteine is reported.

  4. ferroptosis regulator Gpx4 is critical for hepatocyte survival and proper liver function, and that vitamin E can compensate for its loss by protecting cells against deleterious lipid peroxidation.

  5. These data suggest that systemic inactivation of the Alox15 gene normalizes the reduced fertility of male Sec46Ala-Gpx4(+/-) mice by improving the motility of their sperm. If these data can be confirmed in humans, ALOX15 inhibitors might counteract male infertility related to GPX4 deficiency.

  6. Phospholipid hydroperoxide glutathione peroxidase (show GPX1 ELISA Kits) is involved in the maintenance of male fertility under cryptorchidism in mice

  7. dramatic motor neuron degeneration and paralysis induced by Gpx4 ablation suggest that ferroptosis inhibition by GPX4 is essential for motor neuron health and survival in vivo

  8. The lack of catalytic activity is the major reason for the embryonic lethality of Gpx4 knockout mice.

  9. Homozygous expression of Gpx4 with a targeted substitution of selenocysteine to serine causes early embryonic death as expected but, unexpectedly, male subfertility in heterozygous mice.

  10. GPx4 suppresses the increase in the VEGF-A protein level, which occurs during the development of pathological CNV, thus partly explaining the protective effect of GPx4 against CNV.

Cow (Bovine) Glutathione Peroxidase (GPX4) interaction partners

  1. GPx-4 has an important role in the physiological control of peroxide tone in the bordering cells of the oviductal lumen

GPX4 Antigen Profile

Antigen Summary

Glutathione peroxidase catalyzes the reduction of hydrogen peroxide, organic hydroperoxide, and lipid peroxides by reduced glutathione and functions in the protection of cells against oxidative damage. Human plasma glutathione peroxidase has been shown to be a selenium-containing enzyme and the UGA codon is translated into a selenocysteine. Through alternative splicing and transcription initiation, rat produces proteins that localize to the nucleus, mitochondrion, and cytoplasm. In humans, experimental evidence for alternative splicing exists\; alternative transcription initiation and the cleavage sites of the mitochondrial and nuclear transit peptides need to be experimentally verified.

Gene names and symbols associated with GPX4

  • glutathione peroxidase 4 (GPX4) antibody
  • glutathione peroxidase 4 (Gpx4) antibody
  • glutathione peroxidase 4a (gpx4a) antibody
  • 1700027O09Rik antibody
  • ATGPX4 antibody
  • cb563 antibody
  • cb691 antibody
  • F11L15.5 antibody
  • glutathione peroxidase 4 antibody
  • GP-GPx4 antibody
  • gpx-4 antibody
  • GSHPx-4 antibody
  • MCSP antibody
  • mtPHGPx antibody
  • Phgpx antibody
  • PHGPxa antibody
  • sb:cb563 antibody
  • snGpx antibody
  • snPHGPx antibody
  • wu:fb82e03 antibody
  • zgc:92253 antibody

Protein level used designations for GPX4

phospholipid hydroperoxidase , phospholipid hydroperoxide glutathione peroxidase, mitochondrial , sperm nucleus glutathione peroxidase , GSHPx-4 , phospholipid hydroperoxide glutathione peroxidase, nuclear , glutathione peroxidase 4 , GPx-4 , sperm nuclei glutathione peroxidase , glutathione peroxidase 4 (phospholipid hydroperoxidase) , phospholipid hydroperoxide glutathione peroxidase

2879 Homo sapiens
29328 Rattus norvegicus
352928 Danio rerio
625249 Mus musculus
819427 Arabidopsis thaliana
399537 Sus scrofa
286809 Bos taurus
100730119 Cavia porcellus
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