Glutathione Peroxidase (GPX4) ELISA Kits

May constitute a glutathione peroxidase-like protective system against oxidative stresses (By similarity). Additionally we are shipping GPX4 Antibodies (118) and GPX4 Proteins (11) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
GPX4 2879 P36969
GPX4 29328 P36970 , Q91XR8
GPX4 625249 O70325 , Q91XR9
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Top GPX4 ELISA Kits at

Showing 3 out of 7 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Delivery Price Details
Mouse 7.81 pg/mL 31.25-2000 pg/mL Typical standard curve 96 Tests 15 to 18 Days
Rat 1.17 4.68 Typical standard curve 96 Tests 15 to 18 Days
Human 1.95 7.8 Typical standard curve 96 Tests 15 to 18 Days

More ELISA Kits for GPX4 Interaction Partners

Human Glutathione Peroxidase (GPX4) interaction partners

  1. GPX4 is highly expressed in renal clear cell carcinoma cells, which is positively correlated with the expression of IGF-1R and COX-2, and can promote cell proliferation and metastasis in vitro.

  2. results clearly show that mRNA expression for all three GPx4 isoforms (cytoplasmic, mitochondrial and nuclear) decline in multiple sclerosis gray matter and in the spinal cord of mice with experimental autoimmune encephalomyelitis

  3. Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer.

  4. Letter: glutathione peroxidase 4 variant rs713041 modulated the risk for cardiac autonomic neuropathy in the studied population with type 1 diabetes.

  5. ALOX12 missense mutations from human cancers abrogate its ability to oxygenate polyunsaturated fatty acids and to induce p53-mediated ferroptosis. Notably, ALOX12 is dispensable for ferroptosis induced by erastin or GPX4 inhibitors; conversely, ACSL4 is required for ferroptosis upon GPX4 inhibition but dispensable for p53-mediated ferroptosis

  6. Results provide evidence that the functional SNPs rs17883901 in GCLC and rs713041 in GPX4 modulate the risk for diabetic retinopathy in the studied population of type 1 diabetes individuals, widening the spectrum of candidate genes for this complication.

  7. FINO2 both indirectly inhibits GPX4 enzymatic function and directly oxidizes iron, ultimately causing widespread lipid peroxidation.

  8. we showed that the activation of ferroptosis by erastin increased the levels of lysosome-associated membrane protein 2a to promote chaperone-mediated autophagy (CMA), which, in turn, promoted the degradation of GPX4. Importantly, inhibition of CMA stabilized GPX4 and reduced ferroptosis. Our results suggest that activation of CMA is involved in the execution of ferroptosis.

  9. GPX4 regulates reactive oxygen species-induced cell death.

  10. that polymorphisms in GPX1 and GPX4 are significantly associated with episodic memory and AD in a South Brazilian population

  11. Crystal structure and functional characterization of selenocysteine-containing GPX4 suggests an alternative mechanism of peroxide reduction.

  12. Results suggest that single nucleotide polymorphism rs713041 in glutathione peroxidase 4 (GPx4) may play a key role in the pathogenesis of preeclampsia (PE).

  13. Targeting Dependency on the GPX4 Lipid Peroxide Repair Pathway for Cancer Therapy.

  14. The results indicate that the single-nucleotide polymorphism rs713041 in GPX4 gene could modulate the pattern of global gene expression. Supplementation with Brazil nuts can modify the gene expression of some selenoproteins depending upon the presence of genetic polymorphisms.

  15. GPX1, GPX3 and GPX4 may be upregulated in response to a change in oxidative stress during an acute coronary syndromes

  16. The proliferation of GPx4 siRNA-treated cells was downregulated compared with that of control siRNA-treated cells. GPx4 knockdown enhanced hydrogen peroxide- and ferrous sulfate-induced cytotoxicity.

  17. High GPX4 expression is associated with oral squamous cell carcinoma.

  18. By screening peptide libraries displayed on T7 phages, and analyzing the X-ray crystal structures of the peptides, we successfully identified one peptide that binds to near Sec73 of catalytic site and two peptides that bind to another site on GPX4. To our knowledge, this is the first study reporting GPX4 inhibitory peptides and their structural information.

  19. use GPX4 and GPX7 as possible markers for improving HCC diagnosis/prognosis.

  20. One SNP (rs3746162) in GPX4 was significantly associated with bladder cancer recurrence after transurethral resection.

Zebrafish Glutathione Peroxidase (GPX4) interaction partners

  1. We found that the gpx4b gene shows maternal and zygotic gene expression in the embryo proper compared to gpx4a that showed zygotic gene expression in the periderm covering the yolk cell only.

Mouse (Murine) Glutathione Peroxidase (GPX4) interaction partners

  1. results clearly show that mRNA expression for all three GPx4 isoforms (cytoplasmic, mitochondrial and nuclear) decline in multiple sclerosis gray matter and in the spinal cord of mice with experimental autoimmune encephalomyelitis

  2. Genetic inactivation of GPX4 increases lipid peroxidation, thus exacerbating GSDMD-mediated pyroptosis in macrophages as well as septic lethality in mice.

  3. Selenium-containing GPX4 is necessary for full viability of mice. Survival of a specific type of interneurons depends on selenocysteine-containing GPX4, thereby preventing fatal epileptic seizures.

  4. paternal acetylated histones and acrosomal nuclear GPx4 are directly involved in fertilization.

  5. Gpx4 was dispensable for the maintenance of cellular health and function of POMC neurons, even in mice exposed to obesogenic conditions. In contrast, HFHS-fed mice with Gpx4 deletion from AgRP neurons displayed increased body adiposity. Gpx4 deletion from dopaminergic neurons induced anxiety behavior, and diminished spontaneous locomotor activity when DJ-1 was co-deleted.

  6. After tamoxifen treatment to ablate Gpx4, Gpx4BIKO mice developed impairment in hippocampus dependent spatial learning and memory function which was associated with neurodegeneration. Consistent with its role as a regulator of ferroptosis, cognitive impairment and neurodegeneration in Gpx4BIKO mice was associated with elevated lipid peroxidation, ERK(1/2) activation and overt neuroinflammation.

  7. The structure of the cytoplasmic isoform of mouse phospholipid hydroperoxide glutathione peroxidase (O70325-2 GPx4) with selenocysteine 46 mutated to cysteine is reported.

  8. ferroptosis regulator Gpx4 is critical for hepatocyte survival and proper liver function, and that vitamin E can compensate for its loss by protecting cells against deleterious lipid peroxidation.

  9. These data suggest that systemic inactivation of the Alox15 gene normalizes the reduced fertility of male Sec46Ala-Gpx4(+/-) mice by improving the motility of their sperm. If these data can be confirmed in humans, ALOX15 inhibitors might counteract male infertility related to GPX4 deficiency.

  10. Phospholipid hydroperoxide glutathione peroxidase is involved in the maintenance of male fertility under cryptorchidism in mice

  11. dramatic motor neuron degeneration and paralysis induced by Gpx4 ablation suggest that ferroptosis inhibition by GPX4 is essential for motor neuron health and survival in vivo

  12. The lack of catalytic activity is the major reason for the embryonic lethality of Gpx4 knockout mice.

  13. Homozygous expression of Gpx4 with a targeted substitution of selenocysteine to serine causes early embryonic death as expected but, unexpectedly, male subfertility in heterozygous mice.

  14. GPx4 suppresses the increase in the VEGF-A protein level, which occurs during the development of pathological CNV, thus partly explaining the protective effect of GPx4 against CNV.

  15. Inducible disruption of Gpx4 causes acute renal failure and early death in an Alox15-independent manner

  16. A membrane glycoprotein GPX4 was shown to play a significant role in gamete interactions.

  17. Rat Gpx4 is a moonlighting protein that functions both as a peroxidase, as well as a structural protein.

  18. GPx4-overexpressing mice showed no free fatty acid induced increase in reactive oxygen species and lipid peroxidation

  19. Activity of cutaneous GPx4 is linked to the regulation of COX-2 and hair follicle morphogenesis and provides insight into the function of individual selenoprotein activity in maintaining cutaneous homeostasis.

  20. enzymatic epididymal salvage response is sufficient to maintain full fertility of double GPx4 and GPx5 KO males whatever their age, crossed with young WT female mice

Cow (Bovine) Glutathione Peroxidase (GPX4) interaction partners

  1. GPx-4 has an important role in the physiological control of peroxide tone in the bordering cells of the oviductal lumen

GPX4 Antigen Profile

Antigen Summary

Glutathione peroxidase catalyzes the reduction of hydrogen peroxide, organic hydroperoxide, and lipid peroxides by reduced glutathione and functions in the protection of cells against oxidative damage. Human plasma glutathione peroxidase has been shown to be a selenium-containing enzyme and the UGA codon is translated into a selenocysteine. Through alternative splicing and transcription initiation, rat produces proteins that localize to the nucleus, mitochondrion, and cytoplasm. In humans, experimental evidence for alternative splicing exists\; alternative transcription initiation and the cleavage sites of the mitochondrial and nuclear transit peptides need to be experimentally verified.

Gene names and symbols associated with GPX4

  • glutathione peroxidase 4 (GPX4) antibody
  • glutathione peroxidase 4 (Gpx4) antibody
  • glutathione peroxidase 4a (gpx4a) antibody
  • 1700027O09Rik antibody
  • ATGPX4 antibody
  • cb563 antibody
  • cb691 antibody
  • F11L15.5 antibody
  • glutathione peroxidase 4 antibody
  • GP-GPx4 antibody
  • gpx-4 antibody
  • GSHPx-4 antibody
  • MCSP antibody
  • mtPHGPx antibody
  • Phgpx antibody
  • PHGPxa antibody
  • sb:cb563 antibody
  • snGpx antibody
  • snPHGPx antibody
  • wu:fb82e03 antibody
  • zgc:92253 antibody

Protein level used designations for GPX4

phospholipid hydroperoxidase , phospholipid hydroperoxide glutathione peroxidase, mitochondrial , sperm nucleus glutathione peroxidase , GSHPx-4 , phospholipid hydroperoxide glutathione peroxidase, nuclear , glutathione peroxidase 4 , GPx-4 , sperm nuclei glutathione peroxidase , glutathione peroxidase 4 (phospholipid hydroperoxidase) , phospholipid hydroperoxide glutathione peroxidase

2879 Homo sapiens
29328 Rattus norvegicus
352928 Danio rerio
625249 Mus musculus
819427 Arabidopsis thaliana
399537 Sus scrofa
286809 Bos taurus
100730119 Cavia porcellus
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