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The GLRA3 gene encodes the alpha-3 subunit of the neuronal glycine receptor, a ligand-gated chloride channel composed of ligand-binding alpha and structural beta polypeptides (Kingsmore et al., 1994 [PubMed 7894176]).[supplied by OMIM, Nov 2009].. Additionally we are shipping Glycine Receptor, alpha 3 Antibodies (10) and and many more products for this protein.
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X-ray crystal structure of human homopentameric GlyRalpha3 in complex with AM-3607, a potentiator of the same class with increased potency, and the agonist glycine, at 2.6-A resolution.
3.0 A X-ray structure of the human glycine receptor (show GLRB Proteins)-alpha3 homopentamer in complex with a high affinity, high-specificity antagonist, strychnine
Protein kinase (show CDK7 Proteins) (PK)A-dependent phosphorylation of alpha3 GlyRs (show GARS Proteins) produces a conformational change that propagates to the glycine-binding site.
Results indicate that the multifunctional basic motif of the TM3 (show TPM1 Proteins)-4 loop is capable of mediating a karyopherin-dependent intracellular sorting of full-length GlyRs (show GARS Proteins).
This experiments identify the alpha3 subunit of the glycine receptor (show GLRB Proteins) as a target of modulation in a mouse model of Rett syndrome.
alpha2 and alpha3 GlyRs (show GARS Proteins) are present in various regions of the forebrain and that alpha3 GlyRs (show GARS Proteins) specifically participate in tonic inhibition in the striatum and prefrontal cortex.
loss of alpha3-GlyRs (show GARS Proteins) in mice compromises suprathreshold auditory nerve activity, but not outer hair cell function
GlyRalpha3 KO animals showed significantly impaired prepulse inhibition of the auditory startle response and changes in auditory brainstem response.
Findings suggest that trigeminal primary afferent boutons receive presynaptic modulation via homomeric, extrasynaptic glycine receptor subunit alpha 3, and that different subtypes of glycine receptors may be involved in pre- and postsynaptic inhibition.
The postsynaptic clusters of a3-containing GlyRs (show GARS Proteins) werelocated to efferent synapses of the medial and lateral olivocochlear bundle in the murine organ of Corti beyond the onset of hearing.
Both GlyRalpha2 and GlyRalpha3 modulate local receptive fields in the retina: GlyRalpha3 mediates serial inhibition, whereas GlyRalpha2 participates in crossover inhibition.
Spinal glycine receptor (show GLRB Proteins) alpha3 subunit does not contribute to pain after peripheral nerve injury or formalin injection.
Glycinergic sIPSCs of amacrine cells displayed medium fast kinetics (mean decay time constant tau=11+/-2 ms), which were completely absent in the Glra3-/- mouse.
The GLRA3 gene encodes the alpha-3 subunit of the neuronal glycine receptor, a ligand-gated chloride channel composed of ligand-binding alpha and structural beta polypeptides (Kingsmore et al., 1994
glycine receptor alpha 3 subunit
, glycine receptor subunit alpha-3
, glycine receptor, alpha-3 polypeptide
, ligand gated ion channel
, glycine receptor, alpha 3 subunit
, glycine receptor, alpha 3
, Glycine receptor subunit alpha-3-like
, glycine receptor subunit alpha-3-like