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GPM6A encodes the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. Additionally we are shipping Glycoprotein M6A Proteins (5) and Glycoprotein M6A Kits (2) and many more products for this protein.
Showing 10 out of 86 products:
Human Polyclonal GPM6A Primary Antibody for ELISA, WB - ABIN4315546
Morrison, Felix, Cupples, Glazer, Loehr, Dehghan, Demissie, Bis, Rosamond, Aulchenko, Wang, Haritunians, Folsom, Rivadeneira, Benjamin, Lumley, Couper, Stricker, ODonnell, Rice, Chang, Hofman, Levy et al.: Genomic variation associated with mortality among adults of European and African ancestry with heart failure: the cohorts for heart and aging research in genomic epidemiology consortium. ... in Circulation. Cardiovascular genetics 2010
methylation at m6A by METTL3 (show METTL3 Antibodies)/METTL14 (show METTL14 Antibodies) facilitates the methylation of m5C by NSUN2 (show NSUN2 Antibodies), and vice versa. NSUN2 (show NSUN2 Antibodies)-mediated m5C and METTL3 (show METTL3 Antibodies)/METTL14 (show METTL14 Antibodies)-mediated m6A methylation synergistically enhance p21 (show CDKN1A Antibodies) expression at the translational level
loss of METTL3 (show METTL3 Antibodies) leads to increased levels of phosphorylated AKT (show AKT1 Antibodies), which contributes to the differentiation-promoting effects of METTL3 (show METTL3 Antibodies) depletion. Overall, these results provide a rationale for the therapeutic targeting of METTL3 (show METTL3 Antibodies) in myeloid leukemia (show BCL11A Antibodies)
The structure reveals the heterodimeric architecture of the complex and donor substrate binding by METTL3 (show METTL3 Antibodies). Structure-guided mutagenesis indicates that METTL3 (show METTL3 Antibodies) is the catalytic subunit of the complex, whereas METTL14 (show METTL14 Antibodies) has a degenerate active site and plays non-catalytic roles in maintaining complex integrity and substrate RNA binding.
HDAC5 (show HDAC5 Antibodies) emerges as a cellular conductor of MEF2C (show MEF2C Antibodies) and M6a activity and is regulated by miR (show MLXIP Antibodies)-124 and miR (show MLXIP Antibodies)-9 to control neurite development.
For the methylation of adenosine in RNA, Mettl3 (show METTL3 Antibodies) is the catalytically active subunit, while Mettl14 (show METTL14 Antibodies) plays a structural role critical for substrate recognition.
METTL3 (show METTL3 Antibodies) enhances mRNA translation through an interaction with the translation initiation machinery in lung adenocarcinoma cells.
miR (show MLXIP Antibodies)-33a can attenuatenon-small-cell lung carcinoma cells proliferation via targeting to the 3'-untranslated region of METTL3 (show METTL3 Antibodies) mRNA.
Structure of the METTL3 (show METTL3 Antibodies)-METTL14 (show METTL14 Antibodies) complex
findings thus indicate a critical role of correct GPM6A/M6 levels for cognitive function and support a role of the GPM6A duplication for the patient's phenotype
Data indicate that neuronal membrane glycoproteins GPM6A and GPM6B (show GPM6B Antibodies) may act as novel oncogenes in the development of lymphoid leukemia.
GPM6a induces the clustering of lipid rafts and acts as a signal transducer that responds to extracellular signals.
This study demonistrated that M6a is essential for the support of neurite extension in developmental brain.
analysis of actin-independent behavior and membrane deformation exhibited by the four-transmembrane protein M6a
M6a-deficient axons grow actively but are not growth suppressed by antibodies bound to four-transmembrane actin-based glycoprotein M6a concentrated on the edge of the axon growth cone.
expression of shRNA against GPM6A markedly reduced the expression of neuroectodermal-associated genes (OTX1, Lmx1b (show LMX1B Antibodies), En1 (show EN1 Antibodies), Pax2 (show PAX2 Antibodies), Pax5 (show PAX5 Antibodies), Sox1 (show SOX1 Antibodies), Sox2 (show SOX2 Antibodies), and Wnt1 (show WNT1 Antibodies)), and also the number of neural stem cells (NSC) derived from D3mshM6A cells
These results suggest that M6a plays a role in retinal development by regulating neurites, and it may also function to modulate synaptic activities in the adult retina.
This gene encodes the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. This enzyme is involved in the posttranscriptional methylation of internal adenosine residues in eukaryotic mRNAs, forming N6-methyladenosine.
neuronal membrane glycoprotein M6-a
, neuronal proteolipid GPM6A
, glycoprotein M6A
, glycoprotein M6A L homeolog
, glycoprotein M6A, myelin PLP-related membrane protein DM beta