anti-Gonadotropin-Releasing Hormone Receptor (GNRHR) Antibodies

Human Gonadotropin-Releasing Hormone Receptor (GNRHR) interaction partners

1. Models showed that congenital Glu(2.53(90))Lys and Glu(2.53(90))Asp mutations disrupt interactions with Ser(3.35(124)) and Trp(6.48(280)) respectively, whereas the Glu(2.53(90))Arg and Trp(6.48(280))Arg mutations preserve intramolecular contacts, but increase distance between the transmembrane helices. This disruption of interhelical contacts accounts for the effects of some disease-associated GnRH receptor mutations.

2. role of ELAVL1 in GnRHR-mediated regulation of gene expression and LH secretion but also indicate that other factors may contribute to the precise fate of mRNA in response to GnRH stimulation of gonadotropes.

3. the first homozygous nonsense mutation in the GNRHR gene (chr4: g. 68619942G>A, c.112C>T, p. Arg38*) that is associated with familial Kallmann syndrome and normosmic CHH.

4. findings expand the GnRHR mutation spectrum and phenotype-genotype correlation in Congenital Hypogonaotrophic Hypogonadism.

5. GnRHR triggers intracellular signaling pathways that acts through ARHGAP18.

6. Data, including identification of GnRH/GnRH-receptor system in both ovary and endometrium, suggest that the spectrum of action of GnRH/GnRH-receptor system extends outside its well-known hypothalamic functions. [REVIEW]

7. c.364C>T in GNRHR is a complete loss-of-function mutation which caused idiopathic hypogonadotropic hypogonadism.

8. GNRHR (and GNRH) are expressed in trophoblast cell populations and fallopian tube epithelium at tubal ectopic pregnancy sites.

9. first description of a GNRHR gene mutation in three patients diagnosed with polycystic ovary syndrome.

10. We showed that GNRHR and LHCGR were highly expressed in some wildtype aldosterone-producing adenoma samples, and that they positively correlated with GnRH-stimulated aldosterone production.

11. Results show that biallelic gonadotropin releasing hormone receptor (GNRHR) mutations are not a frequent cause of age-related androgen decline in men.

12. GnRH receptors on triple negative breast cancer cells can be used for targeted therapy of these cancers with GnRH agonist triptorelin

13. analysis of information transfer via gonadotropin-releasing hormone receptors to extracellular signal-regulated kinase or nuclear factor of activated T-cells

14. study found a novel mutation in PROK2 in two male siblings presenting normosmic congenital hypogonadotropic hypogonadism, in whom a mutation in the GNRHR gene had been previously described, suggesting the possibility of a digenic inheritance

15. Data suggest differences in regulation of expression of PEDF (up-regulation) vs. VEGF (down-regulation) in granulosa cells explain reduced risk of ovarian hyperstimulation syndrome due to ovulation induction using GnRH/GNRHR agonists rather than hCG.

16. A high prevalence of endometriosis, polymorphism in the LHCGR and GnRH1 and progonadoliberin-2 antibodies in serum was found among the patients with severe dysmotility after treatment with GnRH analogs.

17. No abnormalities were found in the patient group for the PROKR2 and GNRH1genes. In addition, no genomic rearrangements were identified in the healthy control individuals for the described genes

18. Mutations were found in the following genes in one or more patients with congenital hypogonadotropic hypogonadism: KAL1, FGFR1, GNRHR, and CHD7

19. Mutations in GNRHR do not appear to be involved in the pathogenesis of constitutional delay of growth and puberty.

20. GnRH, through heterotopic expression of its receptor, may be a potential regulator of CYP11B2 expression levels in some cases of aldosterone-producing adenoma.

Rabbit Gonadotropin-Releasing Hormone Receptor (GNRHR) interaction partners

1. These results suggest that GNRHR-I is constitutively expressed in rabbit corpora lutea independently of luteal stage of pseudopregnant rabbits.

Mouse (Murine) Gonadotropin-Releasing Hormone Receptor (GNRHR) interaction partners

1. GnRH receptorexpression levels depend on JUN and are critical for reproductive function.

2. leptin's direct stimulatory actions on gonadotrope GnRHR correlate with a direct inhibition of expression of the posttranscriptional regulator MSI1. There also is a direct MSI1 interaction with 3'-UTR of Gnrhr mRNA.

3. the age-dependent basal and regulated Gnrhr transcription could account for the initial blockade and subsequent activation of the reproductive system during development.

4. GnRH-GnRHR system is not essential for growth or motor/sensory/orientation behavior during the first month of life prior to puberty onset. The lack of the GnRH-GnRHR axis, however, did affect females resulting in reduced subcutaneous inguinal fat pad weight and increased glucose with possible insulin resistance.

5. His305 of the GnRH receptor forms two distinct interactions that determine binding to GnRH and couple agonist binding to the conserved transmembrane domain network that activates GPCRs.

6. The aims of this study were to explore whether mRNA-levels of gonadotropin-releasing hormone (Gnrh) and its receptor (Gnrhr) were changed in plaque-bearing Alzheimer's disease transgenic mice.

7. Data confirm that Gnrhr mRNA and protein are expressed in ovaries, granulosa cells, cumulus cells, and oocytes.

8. Msx1 functions as a negative regulator early in pituitary development by repressing the gonadotrope-specific alphaGSU and GnRHR genes.

9. These results suggest decreased GnRH receptor signaling in the mutant animal, compared with wild type.

10. Report down-regulation of ErbB4 expression in hypothalamic neurons induced by G-protein-coupled gonadotropin releasing hormone receptor stimulation.

11. GnRHR neurons were found in different brain areas. Many GnRHR neurons were identified in areas influencing sexual behaviors

12. A comprehensive knowledgebase of the GnRHR signaling in the LbetaT2 cell, was curated.

13. Null Gnrhr mice had small sexual organs, low levels of FSH, LH, and steroid hormones, failure of sexual maturation, infertility, and inability to respond to exogenous GnRH.

14. GnRH and dex synergistically activate the endogenous GnRHR promoter in L beta T2 cells

15. role of regulatory elements and their cognate transcription factors in transactivation of the mGnRHR gene

16. an intact AP-1 element is necessary for GnRH responsiveness of the GnRHR gene; results suggest a critical role for JNK in mediating GnRH regulation of the GnRHR gene

17. the GnRH receptor activating sequence is a composite regulatory element whose functional activity is dependent on the organization of a multi-protein complex consisting of Smads, AP-1 and a member of the forkhead family of DNA binding proteins

18. Data suggest that activin receptor II signaling is critical only for follicle-stimulating hormone homeostasis and not for gonadotrophin-releasing hormone (GnRH)biosynthesis or induction of pituitary GnRH receptor expression.

19. Results suggest that pituitary homeobox 1 (Pitx-1) can direct transactivation of the mouse gonadotropin-releasing hormone receptor gene, in part by DNA binding and in part by an action of Pitx-1 as a cofactor for AP-1 [Pitx-1].

20. NF-Y and Oct-1 bind to the SURG-1 element to direct basal and GnRH-stimulated expression of the mGnRHR gene

Cow (Bovine) Gonadotropin-Releasing Hormone Receptor (GNRHR) interaction partners

1. The GRIA1 polymorphism exists in beef cows but it does not influence antral follicle numbers. The association between GnRHR genotype and age at first calving is likely not causal as this polymorphism is not functional.

2. There was a significant correlation between frequency profile and timing of puberty among the studied breeds, which seems to suggest that genetic variation within bovine GNRHR gene could explain at least part of the reported variability.

3. These results indicate that GnRHR gene can be a potential marker for improving sperm quality traits, and imply that bulls with GA or CT genotype should be selected in breeding program.

4. Seven sequence variants (SVs) have been identified in exon 1 and in the promoter region upstream of the bovine gonadotrophin releasing hormone (GnRH) receptor; g.-108T>C alteration was associated with beneficial effects on fertility

Rainbow Trout (Oncorhynchus mykiss) Gonadotropin-Releasing Hormone Receptor (GNRHR) interaction partners

1. Data show that GnRH stimulates phagocytosis in fish leucocytes through a GnRH-receptor-dependent pathway.

2. Gene expression regulation during sex maturation in male salmon.