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Increased seminal granulysin has a negative impact on spermatogenesis in infertile men in general and in infertility associated with varicocele in particular.
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The results suggest granulysin as a novel marker for a subset of cytotoxic natural killer cell derived malignancies
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These results suggest that the 15 kDa granulysin exhibits a novel mechanism in bacteria killing in a way that's different from most antimicrobial peptides.
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Decreased blood granulysin at the protein level, is linked to the immunological condition of latent tuberculosis infection.
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Carbamate pesticides significantly reduced the intracellular levels of perforin, GrA, GrB, Gr3/K, and GRN in NK-92CI cells.
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serum GNLY is closely associated with the clinical characteristics of nasopharyngeal carcinoma and may be a potential biomarker for nasopharyngeal carcinoma
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GNLY delivers Gzms into three protozoan parasites (Trypanosoma cruzi, Toxoplasma gondii and Leishmania major), in which the Gzms generate superoxide and inactivate oxidative defense enzymes to kill the parasite.
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Studies indicate that cytotoxic mechanisms mediated by granulysin and TRAIL (TNF-related apoptosis inducing ligand) seem to be less secondary effects on normal tissues.
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High Granulysin expression is associated with Cutaneous T Cell Lymphoma and Sezary Syndrome.
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A three-way interaction between SNPs in HLA-DQ and GNLY was identified in terms of HBV clearance.
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GNLY-expressing lymphocytes, probably attracted by IL-15, not only participate partially in myocardial cell apoptosis, but also hasten resolution of cardiac leukocyte infiltration in patients with myocardial infarction.
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Peptides encoded by this gene display antimicrobial activity against S. typhimurium, L. monocytogenes, E. coli, S. aureus, C. neoformans, C. albicans, L. major, and M. tuberculosis.
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Serum granulysin levels were significantly elevated in both acute and chronic alopecia areata patients.
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Human, but not rodent, cytotoxic granules also contain granulysin, an antimicrobial peptide in addition to granzymes; study shows that granulysin delivers granzymes into bacteria to kill diverse bacterial strains.
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It was concluded taht granulysin induces apoptosis on hematological tumor cells and on cells from B-cell lymphocytic leukemia patients, opening the door to research on its use as a new anti-tumoral treatment.
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suggested that the alteration of circulating granulysin has potential function in host immune response against TB and HIV/TB coinfection
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study to determine: expression of GNLY at the gene and protein levels at the maternal-fetal interface, relationship(s) between GNLY and perforin, and GNLY secretion by stimulated NK cells
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Granulysin is closely associated with the characteristics of NK-cell neoplasms and serum granulysin may serve as a novel biomarker for these disorders.
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GNLY polymorphism genotypes and diplotypes were associated with the chronicity of HBV
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recombinant 15 kDa granulysin is not cytolytic but is a potent inducer of monocytic differentiation to dendritic cells
