Synonyms: 519, D2S69E, GNLY, GNLY_HUMAN, Granulysin, LAG 2, LAG2, Lymphocyte activation gene 2, Lymphokine LAG 2, Lymphokine LAG-2, NKG 5, NKG5, Protein NKG5, T cell activation protein 519, T lymphocyte activation gene 519, T-cell activation protein 519, TLA519
Background: Granulysin is a substance released by cytotoxic T cells(CD8) when they are attached to infected body cells. The product of this gene is a member of the saposin-like protein(SAPLIP) family. It is mapped to 2p11.2. Granulysin functions to create holes in the target cell membrane and destroy it. It is able to induce apoptosis in target cells and also has antimicrobial action. This gene is expressed in cytolytic granules with perforin, a pore forming protein, and granzymes that are also involved in cytolysis. In addition to it, Granulysin is broadly antimicrobial, killing microbes that cause, for example, tuberculosis and malaria, and can destroy some tumors. A series of peptides generated from the amino acid sequence of Granulysin are potential antibiotics. It has been found that secretory Granulysin is a key molecule responsible for the disseminated keratinocyte death in SJS/TEN.
Gene Name: GNLY
Production: Natural and recombinant human Granulysin. There is no detectable cross-reactivity with other relevant proteins.
Standard: Expression system for standard: NSO, Immunogen sequence: M1-L145