anti-Granzyme M (Lymphocyte Met-Ase 1) (GZMM) Antibodies

Human natural killer (NK) cells and activated lymphocytes express and store a distinct subset of neutral serine proteases together with proteoglycans and other immune effector molecules in large cytoplasmic granules. Additionally we are shipping GZMM Kits (14) and GZMM Proteins (11) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
GZMM 3004 P51124
GZMM 29252  
GZMM 16904  
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Top anti-GZMM Antibodies at antibodies-online.com

Showing 10 out of 54 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Rabbit Un-conjugated WB Western blot analysis of Granzyme M expression in HeLa (A), PC12 (B), NS-1 (C) whole cell lysates. 200 μL 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated ICC, IHC, WB Western Blot; Sample: Human Jurkat cell lysate; Primary Ab: 1µg/ml Rabbit Anti-Human GZMM Antibody Second Ab: 0.2µg/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (Catalog: SAA544Rb19) 100 μg 15 to 18 Days
$316.00
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of GZMM Antibody (Center) in K562 cell line lysates (35 µg/lane). GZMM (arrow) was detected using the purified Pab. 0.4 mL 6 to 8 Days
$484.00
Details
Human Rabbit Un-conjugated ELISA, WB   100 μL Available
$363.46
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis of GZMM Antibody in K562 cell line lysates (35ug/lane) GZMM Antibody IHC analysis in formalin fixed and paraffin embedded human lymph tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. 400 μL 2 to 3 Days
$515.63
Details
Rat Rabbit Un-conjugated ICC, IHC, IHC (p), IP, WB Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE) 100 μL 11 to 14 Days
$390.50
Details
Human Rabbit Un-conjugated ELISA, IHC, WB Western blot analysis of GZMM expression in K562 cell line lysates ;,The lane on the left is treated with the antigen-specific peptide. ABIN6273509 at 1/100 staining Human Melanoma tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. 100 μL 11 to 12 Days
$390.77
Details
Mouse Rabbit Un-conjugated ICC, IHC, WB Figure.DAB staining on IHC-P. Samples: Mouse Tissue 100 μg 13 to 16 Days
$324.00
Details
Rat Rabbit Un-conjugated ICC, IHC, WB Figure.DAB staining on IHC-P. Samples: Rat Tissue 100 μg 13 to 16 Days
$342.00
Details
Human Rabbit Un-conjugated IF/ICC, IHC, IP, WB Western blot analysis of Human K562 cell lysate, using Human GZMM Antibody (1 µg/ml) and HRP-conjugated Goat Anti-Rabbit antibody ( Western blot analysis of Human Jurkat cell lysate, using Rabbit Anti-Human GZMM Antibody (1 µg/ml) and HRP-conjugated Goat Anti-Rabbit antibody (abx400043, 0.2 µg/ml). 100 μg 11 to 18 Days
$412.19
Details

Top referenced anti-GZMM Antibodies

  1. Human Monoclonal GZMM Primary Antibody for ELISA, WB - ABIN516325 : Schiffer, Letzian, Jost, Mladenov, Hristodorov, Huhn, Fischer, Barth, Thepen: Granzyme M as a novel effector molecule for human cytolytic fusion proteins: CD64-specific cytotoxicity of Gm-H22(scFv) against leukemic cells. in Cancer letters 2013 (PubMed)

More Antibodies against GZMM Interaction Partners

Human Granzyme M (Lymphocyte Met-Ase 1) (GZMM) interaction partners

  1. GzMM has a critical role during early stages of inflammation in ulcerative colitis; in its absence colonic inflammation is enhanced.

  2. We also report that TNFalpha induces the attachment of Met1-linked Ub chains directly to TNF receptor 1, which do not seem to be attached covalently to Lys63-linked or other types of ubiquitin chain.

  3. Granzym M may be important in regulating HCMV latency and reactivation in SCT patients.

  4. GrM is expressed in HCMV-specific CD8thorn T cells and cleaves host cell protein hnRNP K in the presence of RNA.

  5. FADD cleavage by NK cell granzyme M enhances its self-association to facilitate procaspase-8 recruitment for auto-processing leading to caspase cascade.

  6. Results indicate that cellular overexpression of SERPINB4 inhibits recombinant GrM-induced as well as NK cell-mediated cell death.

  7. GrM also exists extracellularly in plasma where it could play a physiological role in controlling blood coagulation by determining plasma FVIII levels via proteolytic processing of its carrier VWF.

  8. Results describe the structural characterization of granzyme M by molecular modeling as well as by detailed comparison with other granzymes.

  9. Noncytotoxic inhibition of cytomegalovirus replication through NK cell protease granzyme M-mediated cleavage of viral phosphoprotein 71.

  10. survivin cleavage by Granzyme M triggers degradation of the survivin-X-linked inhibitor of apoptosis protein (XIAP) complex to free caspase activity leading to cytolysis of target tumor cells

  11. These findings support not only a role for GrM in the innate but also in the adaptive immune response.

  12. GM expression is a distinctive feature of the nasal NK/T-cell, gamma delta T-cell, and intestinal T-cell lymphomas, and suggest that these tumors develop from lymphocytes involved in innate immunity.

  13. granzyme M represents a third major and specialized perforin-dependent cell death pathway that plays a significant role in death mediated by NK cells

  14. proteinase inhibitor 9 was effectively hydrolyzed and inactivated by human granzyme M, raising the possibility that this orphan granzyme bypasses proteinase inhibitor 9 inhibition of granzyme B

  15. Granzyme (Gzm)M can directly degrade inhibitor of caspase-activated DNase (ICAD) to activate CAD, leading to DNA damage; GzmM cleaves DNA damage sensor enzyme poly(ADP-ribose) polymerase to prevent cellular DNA repair and force apoptosis.

  16. Granzyme M targets major components of the cytoskeleton that likely contribute to natural killer (NK) cell-induced cell death.

  17. NPM is essential for cell viability, these data suggest that targeting of NPM by granzyme M may contribute to tumor cell eradication by abolishing NPM function.

  18. Structure-based mutagenesis reveals that the amino-terminus and catalytic triad of GzmM are most essential for proteolytic function.

Mouse (Murine) Granzyme M (Lymphocyte Met-Ase 1) (GZMM) interaction partners

  1. GzMM has a critical role during early stages of inflammation in ulcerative colitis; in its absence colonic inflammation is enhanced.

  2. Granzyme M regulates the release of natural killer cell MIP-1alpha to initiate innate immune responses.

  3. Natural killer (NK) cell GrzM augments the inflammatory cascade downstream of lipopolysaccharide (LPS)-toll-like receptor (TLR)4 signaling, which ultimately results in lethal endotoxicosis.

GZMM Antigen Profile

Protein Summary

Human natural killer (NK) cells and activated lymphocytes express and store a distinct subset of neutral serine proteases together with proteoglycans and other immune effector molecules in large cytoplasmic granules. These serine proteases are collectively termed granzymes and include 4 distinct gene products: granzyme A, granzyme B, granzyme H, and the protein encoded by this gene, granzyme M. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with GZMM

  • granzyme M (LOC100136381) antibody
  • granzyme M (GZMM) antibody
  • granzyme M (Gzmm) antibody
  • granzyme M (lymphocyte met-ase 1) (Gzmm) antibody
  • Lmet1 antibody
  • MET1 antibody
  • MMET-1 antibody

Protein level used designations for GZMM

granzyme M , HU-Met-1 , Met-1 serine protease , lymphocyte met-ase 1 , met-ase , natural killer cell granular protease , RNK-Met-1 , lymphoctye Met-ase 1

GENE ID SPECIES
100136381 Salmo salar
3004 Homo sapiens
29252 Rattus norvegicus
16904 Mus musculus
100233186 Sus scrofa
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