Granzyme M (Lymphocyte Met-Ase 1) (GZMM) ELISA Kits

Human natural killer (NK) cells and activated lymphocytes express and store a distinct subset of neutral serine proteases together with proteoglycans and other immune effector molecules in large cytoplasmic granules. Additionally we are shipping GZMM Antibodies (59) and GZMM Proteins (12) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
GZMM 3004 P51124
GZMM 29252  
GZMM 16904  
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Top GZMM ELISA Kits at antibodies-online.com

Showing 5 out of 23 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Delivery Price Details
Human 24.8 pg/mL 15.6 pg/mL - 1000 pg/mL 96 Tests 13 to 16 Days
$663.16
Details
Mouse 0.06 ng/mL 0.15 ng/mL - 10 ng/mL 96 Tests 13 to 16 Days
$682.11
Details
Rat 8.1 pg/mL 15.625 pg/mL - 1000 pg/mL   96 Tests 15 to 17 Days
$891.06
Details
Pig 8.9 pg/mL 15.625 pg/mL - 1000 pg/mL   96 Tests 15 to 17 Days
$968.71
Details
Pig < 8.9 pg/mL 15.625 pg/mL - 1000 pg/mL   96 Tests 11 to 18 Days
$824.38
Details

Top referenced GZMM ELISA Kits

  1. Human GZMM ELISA Kit for Sandwich ELISA - ABIN6574157 : Bovenschen, Spijkers, Wensink, Schellens, van Domselaar, van Baarle: Elevated granzyme M-expressing lymphocytes during cytomegalovirus latency and reactivation after allogeneic stem cell transplantation. in Clinical immunology (Orlando, Fla.) 2014 (PubMed)

More ELISA Kits for GZMM Interaction Partners

Human Granzyme M (Lymphocyte Met-Ase 1) (GZMM) interaction partners

  1. GzMM has a critical role during early stages of inflammation in ulcerative colitis; in its absence colonic inflammation is enhanced.

  2. We also report that TNFalpha induces the attachment of Met1-linked Ub chains directly to TNF receptor 1, which do not seem to be attached covalently to Lys63-linked or other types of ubiquitin chain.

  3. Granzym M may be important in regulating HCMV latency and reactivation in SCT patients.

  4. GrM is expressed in HCMV-specific CD8thorn T cells and cleaves host cell protein hnRNP K in the presence of RNA.

  5. FADD cleavage by NK cell granzyme M enhances its self-association to facilitate procaspase-8 recruitment for auto-processing leading to caspase cascade.

  6. Results indicate that cellular overexpression of SERPINB4 inhibits recombinant GrM-induced as well as NK cell-mediated cell death.

  7. GrM also exists extracellularly in plasma where it could play a physiological role in controlling blood coagulation by determining plasma FVIII levels via proteolytic processing of its carrier VWF.

  8. Results describe the structural characterization of granzyme M by molecular modeling as well as by detailed comparison with other granzymes.

  9. Noncytotoxic inhibition of cytomegalovirus replication through NK cell protease granzyme M-mediated cleavage of viral phosphoprotein 71.

  10. survivin cleavage by Granzyme M triggers degradation of the survivin-X-linked inhibitor of apoptosis protein (XIAP) complex to free caspase activity leading to cytolysis of target tumor cells

  11. These findings support not only a role for GrM in the innate but also in the adaptive immune response.

  12. GM expression is a distinctive feature of the nasal NK/T-cell, gamma delta T-cell, and intestinal T-cell lymphomas, and suggest that these tumors develop from lymphocytes involved in innate immunity.

  13. granzyme M represents a third major and specialized perforin-dependent cell death pathway that plays a significant role in death mediated by NK cells

  14. proteinase inhibitor 9 was effectively hydrolyzed and inactivated by human granzyme M, raising the possibility that this orphan granzyme bypasses proteinase inhibitor 9 inhibition of granzyme B

  15. Granzyme (Gzm)M can directly degrade inhibitor of caspase-activated DNase (ICAD) to activate CAD, leading to DNA damage; GzmM cleaves DNA damage sensor enzyme poly(ADP-ribose) polymerase to prevent cellular DNA repair and force apoptosis.

  16. Granzyme M targets major components of the cytoskeleton that likely contribute to natural killer (NK) cell-induced cell death.

  17. NPM is essential for cell viability, these data suggest that targeting of NPM by granzyme M may contribute to tumor cell eradication by abolishing NPM function.

  18. Structure-based mutagenesis reveals that the amino-terminus and catalytic triad of GzmM are most essential for proteolytic function.

Mouse (Murine) Granzyme M (Lymphocyte Met-Ase 1) (GZMM) interaction partners

  1. GzMM has a critical role during early stages of inflammation in ulcerative colitis; in its absence colonic inflammation is enhanced.

  2. Granzyme M regulates the release of natural killer cell MIP-1alpha to initiate innate immune responses.

  3. Natural killer (NK) cell GrzM augments the inflammatory cascade downstream of lipopolysaccharide (LPS)-toll-like receptor (TLR)4 signaling, which ultimately results in lethal endotoxicosis.

GZMM Antigen Profile

Antigen Summary

Human natural killer (NK) cells and activated lymphocytes express and store a distinct subset of neutral serine proteases together with proteoglycans and other immune effector molecules in large cytoplasmic granules. These serine proteases are collectively termed granzymes and include 4 distinct gene products: granzyme A, granzyme B, granzyme H, and the protein encoded by this gene, granzyme M. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with GZMM

  • granzyme M (LOC100136381) antibody
  • granzyme M (GZMM) antibody
  • granzyme M (Gzmm) antibody
  • granzyme M (lymphocyte met-ase 1) (Gzmm) antibody
  • Lmet1 antibody
  • MET1 antibody
  • MMET-1 antibody

Protein level used designations for GZMM

granzyme M , HU-Met-1 , Met-1 serine protease , lymphocyte met-ase 1 , met-ase , natural killer cell granular protease , RNK-Met-1 , lymphoctye Met-ase 1

GENE ID SPECIES
100136381 Salmo salar
3004 Homo sapiens
29252 Rattus norvegicus
16904 Mus musculus
100233186 Sus scrofa
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