anti-Growth Arrest-Specific 7 (GAS7) Antibodies

Mouse (Murine) Growth Arrest-Specific 7 (GAS7) interaction partners

1. Gas7-related M1 gene expression in alveolar macrophage was not dependent on NF-kappaB and STAT1 pathway

2. These results demonstrate GAS7 as a susceptibility gene for schizophrenia.

3. Forced expression of Gas7a or Gas7b isoform in mouse neuroblastoma Neuro2A cells, which express a defective Gas7 gene, rendered the cells proapoptotic and vulnerable to cisplatin-induced apoptosis.

4. Gas7 works through its interaction with N-WASP during neuronal maturation/ differentiation

5. Gas7 in PC12 cells leads to an expanded cell morphology and promotes neurite formation. These processes undergo elongation upon addition of nerve growth factor (NGF).

6. Hoxa7 and Hoxa9 contribute to hematopoietic progenitor homeostasis but are not necessary for MLL-GAS7-mediated leukemogenesis

7. The ability of gas7 to potentiate neuronal differentiation makes it a potential therapeutic target to promote re-establishment of neuronal connections in the injured or diseased brain, such as following stroke.

8. Our data reveal that Gas7 might play a role in cellular migration and cell protection in the ES cells of mouse embryo.

9. These results suggest that Gas7 enhances microtubule polymerization by stabilizing sheet intermediates and is a useful tool for analyzing microtubule transformation.

10. Gas7b has a role in microtubular maintenance

Human Growth Arrest-Specific 7 (GAS7) interaction partners

1. A novel regulatory mechanism of p53 in early onset breast cancer progression through GAS7-CYFIP1-mediated signaling pathways.

2. Polymorphism rs11656696 is not associated with primary open angle glaucoma (POAG) nor any of its endophenotypic traits such as intraocular pressure and cup/disk ratio and is thus not a risk factor for POAG in this Saudi cohort

3. Collectively, our findings provide a novel basis for using miR-181a/GAS7-based therapeutic strategies to reverse gefitinib resistance in NSCLC.

4. Among 8 SNPs in 3 loci that showed at least nominal association (P < 5.00E-02) in the primary cohort, a representative SNP for each loci (rs2157719 for CDKN2B-AS1, rs33912345 for SIX6, and rs9913911 for GAS7) were selected

5. These results demonstrate GAS7 as a susceptibility gene for schizophrenia.

6. Low GAS7C increases cancer cell motility by promoting N-WASP/FAK/F-actin cytoskeleton dynamics. It also enhances beta-catenin stability via hnRNP U/beta-TrCP complex formation.

7. We conclude that lower neuronal Gas7b levels may impact Alzheimer disease progression.

8. The results suggest that regulation to maintain an appropriate concentration of hGas7b is required for healthy neurotransmission.

9. These findings indicate that Gas7 is involved in motor neuron function associated with muscle strength maintenance.

10. Intraocular pressure (IOP)was significantly associated with rs11656696, located in GAS7 at 17p13.1 and with rs7555523, located in TMCO1 at 1q24.1.These data suggest that we have identified two clinically relevant genes involved in IOP regulation.

11. regulates the differentiation of mesenchymal stem cells into osteoblasts by enhancing Runx2-dependent gene expression

12. Knockdown of Gas7 by shRNA preferentially suppressed the Gas7b protein isoform in human preneuronal cells and to reduce apoptosis induced either by serum starvation or by the antineoplastic agents in human neuroblastoma SH-SY5Y cells.

13. This work reports the identification of two human Gas7 cDNA: hGas7-a with 2,427 nucleotides, which encodes 330 amino acids, and hGas7-b with 2,610 nucleotides, which encodes 412 amino acids according to predicted open-reading-frames.

14. hGas7b has a role in microtubular maintenance and is possibly implicated in Alzheimer disease