anti-Growth Arrest-Specific 7 (GAS7) Antibodies

Mouse (Murine) Growth Arrest-Specific 7 (GAS7) interaction partners

1. These results demonstrate GAS7 as a susceptibility gene for schizophrenia.

2. Forced expression of Gas7a or Gas7b isoform in mouse neuroblastoma Neuro2A cells, which express a defective Gas7 gene, rendered the cells proapoptotic and vulnerable to cisplatin-induced apoptosis.

3. Gas7 works through its interaction with N-WASP during neuronal maturation/ differentiation

4. Gas7 in PC12 cells leads to an expanded cell morphology and promotes neurite formation. These processes undergo elongation upon addition of nerve growth factor (NGF).

5. Hoxa7 (show HOXA7 Antibodies) and Hoxa9 (show HOXA9 Antibodies) contribute to hematopoietic progenitor homeostasis but are not necessary for MLL-GAS7-mediated leukemogenesis

6. The ability of gas7 to potentiate neuronal differentiation makes it a potential therapeutic target to promote re-establishment of neuronal connections in the injured or diseased brain, such as following stroke.

7. Our data reveal that Gas7 might play a role in cellular migration and cell protection in the ES cells of mouse embryo.

8. These results suggest that Gas7 enhances microtubule polymerization by stabilizing sheet intermediates and is a useful tool for analyzing microtubule transformation.

Human Growth Arrest-Specific 7 (GAS7) interaction partners

1. Collectively, our findings provide a novel basis for using miR (show MLXIP Antibodies)-181a/GAS7-based therapeutic strategies to reverse gefitinib resistance in NSCLC.

2. Among 8 SNPs in 3 loci that showed at least nominal association (P < 5.00E-02) in the primary cohort, a representative SNP for each loci (rs2157719 for CDKN2B (show CDKN2B Antibodies)-AS1 (show PTGDR Antibodies), rs33912345 for SIX6 (show SIX6 Antibodies), and rs9913911 for GAS7) were selected

3. These results demonstrate GAS7 as a susceptibility gene for schizophrenia.

4. Low GAS7C increases cancer cell motility by promoting N-WASP/FAK (show PTK2 Antibodies)/F-actin cytoskeleton dynamics. It also enhances beta-catenin (show CTNNB1 Antibodies) stability via hnRNP U (show HNRNPU Antibodies)/beta-TrCP (show BTRC Antibodies) complex formation.

5. These findings indicate that Gas7 is involved in motor neuron function associated with muscle strength maintenance.

6. Intraocular pressure (IOP)was significantly associated with rs11656696, located in GAS7 at 17p13.1 and with rs7555523, located in TMCO1 (show TMCO1 Antibodies) at 1q24.1.These data suggest that we have identified two clinically relevant genes involved in IOP regulation.

7. regulates the differentiation of mesenchymal stem cells into osteoblasts by enhancing Runx2 (show RUNX2 Antibodies)-dependent gene expression

8. Knockdown of Gas7 by shRNA preferentially suppressed the Gas7b protein isoform in human preneuronal cells and to reduce apoptosis induced either by serum starvation or by the antineoplastic agents in human neuroblastoma (show ARHGEF16 Antibodies) SH-SY5Y cells.

9. This work reports the identification of two human Gas7 cDNA: hGas7-a with 2,427 nucleotides, which encodes 330 amino acids, and hGas7-b with 2,610 nucleotides, which encodes 412 amino acids according to predicted open-reading-frames.