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GDF1 encodes a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. Additionally we are shipping GDF1 Kits (60) and GDF1 Proteins (7) and many more products for this protein.
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Rare inherited and de novo variants in 2,871 congenital heart disease probands identified GDF1, MYH6 (show MYH6 Antibodies), and FLT4 (show FLT4 Antibodies) as causative genes.
Our results suggest that the GDF1 rs4808863 polymorphism contributes to an increased risk of fetal CHDs, especially the subtypes of AVSD, LVOTO and left-right laterality defects.
This implies that Gdf1 potentiates Nodal activity by stabilizing a low molecular weight fraction that is susceptible to neutralization by soluble Acvr2 (show ACVR2A Antibodies).
indicate that the expression of growth/differentiation factor 1 (GDF1) is up-regulated in human dilated cardiomyopathy (DCM)hearts and murine hypertrophic hearts.
GDF1 may be associated with congenital heart defects risk, and these variations contribute at least in part to the development of some subtypes of conotruncal defects in the Chinese Han population.
Molecular genetic basis of a kindred with 5 siblings with right atrial isomerism involved mutations in GDF1.
Heterozygous loss-of-function mutations in the human GDF1 gene contribute to cardiac defects ranging from tetralogy of Fallot to transposition of the great arteries.
GDF1 expression is correlated with progression and aggressive behaviors in cervical cancer, suggesting a tumor-promoting role for GDF1 in the progression of this malignancy.
Epigenetic silencing of GDF1 abrogates the growth-inhibitory SMAD (show SMAD1 Antibodies) signaling and renders proliferation advantage to gastric epithelial cells during carcinogenesis
GDF1 in the heart is a novel mediator that protects against the development of post-infarction cardiac remodelling via negative regulation of the MEK (show MDK Antibodies)-ERK1/2 and Smad (show SMAD1 Antibodies) signalling pathways.
Data indicate that the expression of growth/differentiation factor 1 (GDF1) is up-regulated in human dilated cardiomyopathy (DCM)hearts and murine hypertrophic hearts.
Recombinant mouse GDF1 signaling in zebrafish depends on EGF (show EGF Antibodies)-CFC (show TBCC Antibodies) proteins, but not on Nodal signals. GDF1 binds to and signal through Activin (show Actbeta Antibodies) receptors only in the presence of EGF (show EGF Antibodies)-CFC (show TBCC Antibodies) proteins.
GDF-1 and Nodal converge on ALK4 in the anterior primitive streak to control the formation of organizing centers that are necessary for normal forebrain and branchial arch development
Results suggest that GDF1 and GDF3 (show GDF3 Antibodies) together represent the functional mammalian homologs of Vg1.
GDF1 regulates the activity and signaling range of Nodal through direct interaction
This gene encodes a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site that is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in rodents suggest that this protein is involved in the establishment of left-right asymmetry in early embryogenesis and in neural development in later embryogenesis. This protein is transcribed from a bicistronic mRNA that also encodes the longevity assurance gene.
, embryonic growth/differentiation factor 1