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The protein encoded by GDF10 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily.
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Human Polyclonal GDF10 Primary Antibody for WB - ABIN516005
Cheng, Hsiao, Fan, Lo, Tzen, Wu, Fang, Cheng, Chen, Chang, Jiang, Chang, Lee: Loss of GDF10/BMP3b as a prognostic marker collaborates with TGFBR3 to enhance chemotherapy resistance and epithelial-mesenchymal transition in oral squamous cell carcinoma. in Molecular carcinogenesis 2015
Study shows that GDF10 is down-regulated in patients with oral squamous cell carcinoma, and is an independent risk factor for overall survival. Its expression is regulated by TGFBR3 (show TGFBR3 Antibodies) which shares the signaling inhibiting epithelial-mesenchymal transition.
GDF10 is a stroke-induced signal for axonal sprouting and functional recovery.
new hypoxia-inducible and SOX9 (show SOX9 Antibodies)-regulated genes, Gdf10 and Chm-I (show LECT1 Antibodies). In addition, Mig6 (show ERRFI1 Antibodies) and InhbA (show INHBA Antibodies) were induced by hypoxia, predominantly via HIF-2alpha (show EPAS1 Antibodies)
BMP3b and BMP6 (show BMP6 Antibodies) genes were suppressed by DNA methylation (show HELLS Antibodies) and methylation of BMP3b is significantly frequent in Japanese malignant pleural mesotheliomas (MPMs), suggesting its pathogenic role and the ethnic difference in MPMs.
Results show that Gdf10, expressed in Bergmann glial cells, is affected by the loss of Shh (show SHH Antibodies) as early as E18.5, suggesting a regulation of glial development by Shh (show SHH Antibodies)
Here we show that Runx2 (show RUNX2 Antibodies) is highly expressed in lung cancer cells and downregulates BMP-3B. The ectopic expression of Runx2 (show RUNX2 Antibodies), but not DNA binding mutant Runx2 (show RUNX2 Antibodies), in normal lung fibroblast cells and lung cancer cells resulted in suppression of BMP-3B levels.
data suggest that BMP-3b is secreted from adipocytes, is involved in adipocyte differentiation, and inhibits adipogenesis as a unique complex.
Sca-1 (show Ly6a Antibodies) attenuated GDF10-dependent TGF-beta (show TGFB1 Antibodies) signaling by disrupting the heterodimerization of TbetaRI (show TGFBR1 Antibodies) and TbetaRII receptors.
Gdf10 is expressed in Bergmann glia and is reduced in staggerer mice.
GDF10 gene might have potential effects on body measurement traits in the above mentioned cattle populations and could be used for marker-assisted selection.
The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in mice suggest that the protein encoded by this gene plays a role in skeletal morphogenesis.
growth differentiation factor 10
, bone morphogenetic protein 3B-like
, bone morphogenetic protein 3B
, bone-inducing protein
, prepro bone inducing protein
, growth/differentiation factor 10