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The protein encoded by GDF10 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily.
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Study shows that GDF10 is down-regulated in patients with oral squamous cell carcinoma, and is an independent risk factor for overall survival. Its expression is regulated by TGFBR3 (show TGFBR3 ELISA Kits) which shares the signaling inhibiting epithelial-mesenchymal transition.
GDF10 is a stroke-induced signal for axonal sprouting and functional recovery.
new hypoxia-inducible and SOX9 (show SOX9 ELISA Kits)-regulated genes, Gdf10 and Chm-I (show LECT1 ELISA Kits). In addition, Mig6 (show ERRFI1 ELISA Kits) and InhbA (show INHBA ELISA Kits) were induced by hypoxia, predominantly via HIF-2alpha (show EPAS1 ELISA Kits)
BMP3b and BMP6 (show BMP6 ELISA Kits) genes were suppressed by DNA methylation and methylation of BMP3b is significantly frequent in Japanese malignant pleural mesotheliomas (MPMs), suggesting its pathogenic role and the ethnic difference in MPMs.
Results show that Gdf10, expressed in Bergmann glial cells, is affected by the loss of Shh (show SHH ELISA Kits) as early as E18.5, suggesting a regulation of glial development by Shh (show SHH ELISA Kits)
Here we show that Runx2 (show RUNX2 ELISA Kits) is highly expressed in lung cancer cells and downregulates BMP-3B. The ectopic expression of Runx2 (show RUNX2 ELISA Kits), but not DNA binding mutant Runx2 (show RUNX2 ELISA Kits), in normal lung fibroblast cells and lung cancer cells resulted in suppression of BMP-3B levels.
data suggest that BMP-3b is secreted from adipocytes, is involved in adipocyte differentiation, and inhibits adipogenesis as a unique complex.
Sca-1 (show Ly6a ELISA Kits) attenuated GDF10-dependent TGF-beta (show TGFB1 ELISA Kits) signaling by disrupting the heterodimerization of TbetaRI (show TGFBR1 ELISA Kits) and TbetaRII receptors.
Gdf10 is expressed in Bergmann glia and is reduced in staggerer mice.
GDF10 gene might have potential effects on body measurement traits in the above mentioned cattle populations and could be used for marker-assisted selection.
The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in mice suggest that the protein encoded by this gene plays a role in skeletal morphogenesis.
growth differentiation factor 10
, bone morphogenetic protein 3B-like
, bone morphogenetic protein 3B
, bone-inducing protein
, prepro bone inducing protein
, growth/differentiation factor 10