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Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Additionally we are shipping GRPEL2 Proteins (4) and many more products for this protein.
Showing 10 out of 35 products:
Human Polyclonal GRPEL2 Primary Antibody for IHC, WB - ABIN6681043
Wu, Xiong, Li, Yang, Ge et al.: Integrated Proteomic and Transcriptomic Analysis Reveals Long Noncoding RNA HOX Transcript Antisense Intergenic RNA (HOTAIR) Promotes Hepatocellular Carcinoma Cell Proliferation by Regulating Opioid ... in Molecular & cellular proteomics : MCP 2019
Human Polyclonal GRPEL2 Primary Antibody for ICC, IF - ABIN4316323
Konovalova, Liu, Manjunath, Baral, Neupane, Hilander, Yang, Balboa, Terzioglu, Euro, Varjosalo, Tyynismaa: Redox regulation of GRPEL2 nucleotide exchange factor for mitochondrial HSP70 chaperone. in Redox biology 2018
The dimerization of GRPEL2 may activate the folding machinery responsible for protein import into mitochondrial matrix or enhance the chaperone activity of mitochondrial HSP70, thus protecting mitochondrial proteostasis in oxidative stress.
Data suggest that two putative NEF (nucleotide exchange factors) orthologs, GRPEL1 and GRPEL2, modulate function of mitochondrial HSP70 (mtHSP70); both GRPEL1 and GRPEL2 associate with mtHSP70 as hetero-oligomeric subcomplex and regulate mtHSP70 transport. (GRPEL = mitochondrial GrpE-like protein; HSP70 = heat-shock protein 70)
Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins. Stimulates ATPase activity of mt-HSP70. May also serve to modulate the interconversion of oligomeric (inactive) and monomeric (active) forms of mt-HSP70.
grpE protein homolog 2, mitochondrial
, AFAP1-like protein 1
, actin filament-associated protein 1-like 1