anti-Guanine Nucleotide Binding Protein (G Protein) alpha 12 (GNA12) Antibodies

Human Guanine Nucleotide Binding Protein (G Protein) alpha 12 (GNA12) interaction partners

1. Galpha12 plays a crucial role in human airway smooth muscle contraction via RhoA (show RHOA Antibodies)-dependent activation of the PI3K (show PIK3CA Antibodies)/ROCK axis; targeting Galpha12 signaling may elucidate novel therapeutic targets in asthma

2. the current studies provide evidence showing that c-Jun (show JUN Antibodies) directly binds to a consensus binding sequence within the GNA12-5' regulatory region, thereby regulating GNA12 transcription.

3. we conclude that Galpha12 protects HUVECs[ human umbilical vein endothelial cells ] from serum withdrawal-induced apoptosis by retaining miR (show MLXIP Antibodies)-155 expression.

4. RGS22 (show RGS22 Antibodies) acts as a tumor suppressor, repressing human pancreatic adenocarcinoma cell migration by coupling to GNA12/13.

5. preeclampsia is associated with decreased methylation of the GNA12 promoter

6. Data show that N-linked glycosylation of protease-activated receptor-1 (PAR1 (show F2R Antibodies)) at extracellular loop 2 (ECL2) controls G12 (show TCF3 Antibodies)/13 versus Gq G-proteins coupling specificity in response to thrombin (show F2 Antibodies) stimulation.

7. Significance of Galpha12 upregulation in liver tumor progression, implicating Galpha12 as an attractive therapeutic target.

8. Results show that RMP (show ABCA4 Antibodies) serves as a potent factor contributing to portal vein tumor thrombus by promoting IL-6 (show IL6 Antibodies) transcription.

9. A tyrosine residue at the C-terminus of the Galpha subunit plays an important role in controlling activation of G-protein coupled receptors.

10. Galpha12gep oncogene (show RAB1A Antibodies) inhibits FOXO1 (show FOXO1 Antibodies), which may result from the inhibition of FOXO1 (show FOXO1 Antibodies) de novo synthesis by miR (show MLXIP Antibodies)-135b in conjunction with MDM2 (show MDM2 Antibodies)-mediated destabilization of FOXO1 (show FOXO1 Antibodies).

Zebrafish Guanine Nucleotide Binding Protein (G Protein) alpha 12 (GNA12) interaction partners

1. Gpr56 (show GPR56 Antibodies) regulates oligodendrocyte development via interactions with Galpha12/13 and RhoA (show RHOA Antibodies)

2. Galpha12/13 regulate epiboly by inhibiting E-cadherin activity and modulating the actin cytoskeleton.

Mouse (Murine) Guanine Nucleotide Binding Protein (G Protein) alpha 12 (GNA12) interaction partners

1. Galpha12 is required for the development of kidney cysts induced by Pkd1 (show PKD1 Antibodies) mutation in mouse autosomal dominant polycystic kidney disease.

2. Our data reveal a previously unknown role for Galpha12 in regulating efferocytosis and that renal tubular epithelial cells require KIM-1 (show HAVCR1 Antibodies) to mediate this process.

3. Selective inhibition of G12 (show TCF3 Antibodies)/13 signaling in macrophages can augment atheroprotective B-cell populations and ameliorate atherosclerosis.

4. Gpr56 (show GPR56 Antibodies) regulates oligodendrocyte development via interactions with Galpha12/13 and RhoA (show RHOA Antibodies)

5. results suggest that KIM-1 (show HAVCR1 Antibodies) is an endogenous protective mechanism against renal ischemia-reperfusion injury through inhibition of Galpha12.

6. Pkd1 (show PKD1 Antibodies) mutation or deletion leads to the activation of Galpha12, which promotes the maturation of ADAM10 (show ADAM10 Antibodies) that increases the shedding of E-cadherin (show CDH1 Antibodies) in kidney epithelial cells.

7. Galpha12 may play an important role in promoting membrane trafficking and exocytosis for basal and thrombin (show F2 Antibodies)-induced vWF (show VWF Antibodies) secretion, in a process involving SNAP, Galpha12/13 and Galphaq (show GNAQ Antibodies)/11

8. Data indicate that Pyk2 (show PTK2B Antibodies) is a common signaling effector downstream of both G12 (show TCF3 Antibodies)/13 and integrin alphaIIbbeta3 signaling, which contributes to thromboxane generation.

9. PRR5L (show PRR5L Antibodies) degradation promotes mTORC2 (show CRTC2 Antibodies)-mediated PKC-delta (show PKCd Antibodies) phosphorylation and cell migration downstream of Galpha12 in fibroblasts and pulmonary fibrosis.

10. Expression analysis reveals that production of 5-HT7 and Galpha12 proteins in the hippocampus undergoes strong regulation with a pronounced transient increase during early postnatal stages.