anti-Guanine Nucleotide Binding Protein (G Protein) alpha 12 (GNA12) Antibodies

Human Guanine Nucleotide Binding Protein (G Protein) alpha 12 (GNA12) interaction partners

1. Galpha12 plays a crucial role in human airway smooth muscle contraction via RhoA-dependent activation of the PI3K/ROCK axis; targeting Galpha12 signaling may elucidate novel therapeutic targets in asthma

2. the current studies provide evidence showing that c-Jun directly binds to a consensus binding sequence within the GNA12-5' regulatory region, thereby regulating GNA12 transcription.

3. we conclude that Galpha12 protects HUVECs[ human umbilical vein endothelial cells ] from serum withdrawal-induced apoptosis by retaining miR-155 expression.

4. RGS22 acts as a tumor suppressor, repressing human pancreatic adenocarcinoma cell migration by coupling to GNA12/13.

5. preeclampsia is associated with decreased methylation of the GNA12 promoter

6. Data show that N-linked glycosylation of protease-activated receptor-1 (PAR1) at extracellular loop 2 (ECL2) controls G12/13 versus Gq G-proteins coupling specificity in response to thrombin stimulation.

7. Significance of Galpha12 upregulation in liver tumor progression, implicating Galpha12 as an attractive therapeutic target.

8. Results show that RMP serves as a potent factor contributing to portal vein tumor thrombus by promoting IL-6 transcription.

9. A tyrosine residue at the C-terminus of the Galpha subunit plays an important role in controlling activation of G-protein coupled receptors.

10. Galpha12gep oncogene inhibits FOXO1, which may result from the inhibition of FOXO1 de novo synthesis by miR-135b in conjunction with MDM2-mediated destabilization of FOXO1.

11. CREB is a critical signaling node in Lysophosphatidic acid-Lysophosphatidic acid receptor and Galpha12/gep proto-oncogene stimulated oncogenic signaling in ovarian cancer cells.

12. Galpha12 drives oral squamous cell carcinoma invasion through the up-regulation of IL-6 and IL-8 cytokines.

13. Ga12 activation in podocytes leads to cumulative changes in glomerular collagen expression,proteinuria and glomerulosclerosis.

14. study implicates a G12-stimulated mitogen-activated protein kinase cascade in cancer cell invasion, and supports a role for JNK in cancer progression.

15. In an independent set of 40 banked placental specimens, GNA12 was overexpressed during preeclampsia when co-incident with chronic hypertension

16. that Galpha(i2)-induced signaling can act as a counterbalance to MuRF1-mediated atrophy, indicating that receptors that act through Galpha(i2) might represent potential targets for preventing skeletal muscle wasting.

17. Overexpression of Galpha(s) or Galpha(12) active mutants enhanced androgen-induced androgen receptor transactivation. Galpha(s) active mutant sensitized androgen receptor to castration-level of androgen (R1881).

18. Negative regulation of Gq-mediated pathways in platelets by G(12/13) pathways through Fyn kinase

19. A functional role for JLP in the gep oncogene-regulated neoplastic signaling pathway.

20. Galpha(12/13) regulate AP-1-dependent CYR61 induction in vascular smooth muscle, promoting migration, and they are upregulated with CYR61 in arteriosclerotic lesions.

Zebrafish Guanine Nucleotide Binding Protein (G Protein) alpha 12 (GNA12) interaction partners

1. Gpr56 regulates oligodendrocyte development via interactions with Galpha12/13 and RhoA

2. Galpha12/13 regulate epiboly by inhibiting E-cadherin activity and modulating the actin cytoskeleton.

Mouse (Murine) Guanine Nucleotide Binding Protein (G Protein) alpha 12 (GNA12) interaction partners

1. Galpha12 plays a role in differentiation through NFATc1 and in cell migration and resorption activity through RhoA during osteoclastogenesis.

2. Galpha12 is required for the development of kidney cysts induced by Pkd1 mutation in mouse autosomal dominant polycystic kidney disease.

3. Our data reveal a previously unknown role for Galpha12 in regulating efferocytosis and that renal tubular epithelial cells require KIM-1 to mediate this process.

4. Selective inhibition of G12/13 signaling in macrophages can augment atheroprotective B-cell populations and ameliorate atherosclerosis.

5. Gpr56 regulates oligodendrocyte development via interactions with Galpha12/13 and RhoA

6. results suggest that KIM-1 is an endogenous protective mechanism against renal ischemia-reperfusion injury through inhibition of Galpha12.

7. Pkd1 mutation or deletion leads to the activation of Galpha12, which promotes the maturation of ADAM10 that increases the shedding of E-cadherin in kidney epithelial cells.

8. Galpha12 may play an important role in promoting membrane trafficking and exocytosis for basal and thrombin-induced vWF secretion, in a process involving SNAP, Galpha12/13 and Galphaq/11

9. Data indicate that Pyk2 is a common signaling effector downstream of both G12/13 and integrin alphaIIbbeta3 signaling, which contributes to thromboxane generation.

10. PRR5L degradation promotes mTORC2-mediated PKC-delta phosphorylation and cell migration downstream of Galpha12 in fibroblasts and pulmonary fibrosis.

11. Expression analysis reveals that production of 5-HT7 and Galpha12 proteins in the hippocampus undergoes strong regulation with a pronounced transient increase during early postnatal stages.

12. that Galpha(i2)-induced signaling can act as a counterbalance to MuRF1-mediated atrophy, indicating that receptors that act through Galpha(i2) might represent potential targets for preventing skeletal muscle wasting.

13. Negative regulation of Gq-mediated pathways in platelets by G(12/13) pathways through Fyn kinase

14. Galpha(12/13) regulate AP-1-dependent CYR61 induction in vascular smooth muscle, promoting migration, and they are upregulated with CYR61 in arteriosclerotic lesions.

15. These results suggest that Galpha12 may be a critical signaling molecule in TCR-induced IL-2 production and also relay a signal to suppress Th2 and Th17 cell differentiation.

16. The G alpha(12)-mediated signaling pathway functionally interacts not only with the G alpha(13)- but also with the G alpha(q/11)-mediated signaling systems.

17. Hsp90 binding and acylation of Galpha12 results in localization to lipid rafts

18. data clearly show that Galpha12/Galpha13 proteins as well as Galphaq/Galpha11 protein alone can couple G-protein-coupled receptors to the rapid activation of ras homolog gene family member A(RhoA)

19. intracellular Sphingosine 1-phosphate signaled "inside out" through its cell-surface receptors linked to G12/13-mediated stress fiber formation, important for cell motility

20. Galpha(12) stimulates cell proliferation and neoplastic transformation of NIH3T3 cells by attenuating p38MAPK-associated apoptotic responses, while activating the mitogenic responses through the stimulation of ERK- and JNK-mediated signaling pathways.