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Endogenous activator of intestinal guanylate cyclase. Additionally we are shipping GUCA2A Antibodies (67) and GUCA2A Proteins (6) and many more products for this protein.
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Both guanylin and uroguanylin (show GUCA2B ELISA Kits) trigger lipolysis in human visceral adipocytes. Given the lipolytic action of the guanylin system on visceral adipocytes, the herein reported decrease of circulating prouroguanylin concentrations in obese patients may have a role in excessive fat accumulation in obesity.
Results demonstrate that GC-C (show GUCY2C ELISA Kits) and its ligands, guanylin and uroguanylin (show GUCA2B ELISA Kits) are downregulated in ulcerative colitis (UC), and this downregulation is more significant with aggravation of the clinical condition. Therefore, the GC-C (show GUCY2C ELISA Kits) signaling pathway may be implicated in the progression of UC.
The specific cellular distribution of both GN and UGN (show GUCA2B ELISA Kits) differs between duodenum and colon and between human and rat intestines.
There is differential expression of guanylin in colorectal cancer, and the differential expression is associated with tumor stage.
The myristoylated wild-type GCAP1 was found to have the highest Ca(2 (show CA2 ELISA Kits)+) affinity and thermal stability.
guanylin as a significant marker in salivary gland tumor pathology
It is likely that gallbladder epithelial cells synthesize and release guanylin into the bile to regulate electrolyte secretion by a paracrine/luminocrine signaling pathway.
human cortical collecting duct cells are depolarized by guanylin.
Guanylin plays a role in the regulation of ion transport in the colon
guanylin is synthesized as an intrinsic peptide in epithelial cells of the hepatobiliary system and released luminally into the hepatic and cystic bile to regulate electrolyte secretion by a paracrine/luminocrine signaling pathway
GCAP-1, a Ca(2+)/Mg(2+) sensor protein that accelerates retinal guanylyl cyclase (RetGC) in the light and decelerates it in the dark, is inactive in cation-free form.
guanylin and uroguanylin (show GUCA2B ELISA Kits) are produced by mouse intestinal epithelial cells of columnar and secretory lineage
act on the mouse kidney, in part, through a cGMP-dependent, GC-C (show GUCY2C ELISA Kits)-independent mechanism, causing significant natriuresis by renal tubular processes
These findings suggest that guanylin deficiency causes basal chloride secretion and reduced responsiveness to heat stable (show CD24 ELISA Kits) enterotoxin (STa (show SULT2A1 ELISA Kits)) in mouse proximal colon.
existence of two signaling pathways for guanylin peptides in principal cells of mouse cortical collecting duct of kidney
Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins.
guanylate cyclase activator 2A (guanylin 2, intestinal, heat-stable)
, guanylate cyclase-activating protein 1
, guanylate cyclase-activating protein I
, guanylate cyclase activator 2 (guanylin)
, guanylin-like protein
, guanylyl cyclase activating peptide I
, guanylate cyclase activator 2A (guanylin)
, guanylate cyclase activator 2 (guanylin 2, intestinal, heatstable)