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Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Additionally we are shipping Histone H3.3 Antibodies (33) and Histone H3.3 Proteins (5) and many more products for this protein.
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Downregulation of the H3.3 histone chaperone HIRA (show HIRA ELISA Kits) similarly impairs late gastrulation.
DLP (show DMD ELISA Kits) and ASF1 (show SRSF1 ELISA Kits) are part of a predeposition complex, which is recruited by XNP (show ATRX ELISA Kits) and is necessary to prevent DNA exposure in the nucleus.
FACT and PBAP complexes are recruited to chromatin boundaries in a GAGA factor-dependent manner, and are needed for H3.3 replacement to execute boundary functions.
describe a mechanism of chromatin regulation whereby the variant H3.3 is deposited at particular loci, including active rDNA arrays
Histone H3.3 gene may be required to provide postmeiotic histone H3.3 in the male germ line in transition to chromatin packaging in sperm.
Deposition and inheritance of actively modified H3.3 in regulatory regions maintains transcriptionally active chromatin.
H3F3A is the most frequently mutated giant cell tumor of bone driver gene. H3F3A mutations are not present in atypical giant cell tumor of bone.
H3F3A mutational testing may be a useful adjunct to differentiate giant cell tumor of bone from giant cell-rich sarcoma.
Report H3F3A/B mutations in cell tumors of bone, chondroblastomas, and aneurysmal bone cysts.
We determined the incidence of H3.3 G34 mutations in primary malignant bone tumors as assessed by genotype and H3.3 G34W immunostaining
The kinase activity of Aurora B (show AURKB ELISA Kits) on serine 31 of histone H3.3 was biochemically confirmed with nucleosomal substrates in vitro.
This study showed that heterozygous K27M mutations in H3F3A (n = 4) or HIST1H3B (n = 3) across all primary, contiguous, and metastatic tumor sites in all Diffuse intrinsic pontine glioma.
Study examined the relationship of K27M mutations in the distinct histone H3 (show HIST3H3 ELISA Kits) variants (i.e. HIST1H3B and H3F3A) with specific pontine glioma biology
study found spinal high-grade gliomas in children and adults frequently harbor H3F3A (K27M) mutations
H3F3A and H3F3B mutation analysis appears to be a highly specific, although less sensitive, diagnostic tool for the distinction of GCTB and chondroblastoma from other giant cell-containing tumors.
we describe three interesting cases of paediatric glial and glioneuronal tumours harbouring both BRAF (show BRAF ELISA Kits) V600E and H3F3A K27M mutations.
results point to the importance of integrating histone modifications and MyoD (show MYOD1 ELISA Kits) chromatin binding for coordinated gene activation and repression during myogenic differentiation.
Data show that circulating histone H3 (show HIST3H3 ELISA Kits) increased significantly in necrotizing pancreatitis.
In H3f3a and H3f3b null mouse embryonic stem cells, H3.3 deficiency results in reduced levels of H3K9me3 level, H4K20me3 and ATRX (show ATRX ELISA Kits) at the telomeres, accompanied with an increase in telomeric transcription.
an important function of H3.3 is to support chromosomal heterochromatic structures, thus maintaining genome integrity during mammalian development.
Data indicate a function of the histone H3S28 phosphorylation mark in the activation of mammalian genes in response to MAP kinase (show MAPK1 ELISA Kits) pathway activation.
Data indicate that increased tumor necrosis factor (Tnfa (show TNF ELISA Kits)) and monocyte chemotactic protein 1 (Mcp1 (show CCL2 ELISA Kits); also known as Ccl2 (show CCL2 ELISA Kits)) expression in fatty liver at the chromatin level corresponds to changes in the level of histone H3 (show HIST3H3 ELISA Kits) acetylation.
An H3K9/S10 methyl-phospho switch modulates Polycomb and Pol II binding at repressed genes during differentiation.
Histone H3.3 regulates dynamic chromatin states during spermatogenesis.
H3.3 is a crucial maternal factor (show ZAR1 ELISA Kits) for oocyte reprogramming
Data demonstrate the importance of H3.3 in maintaining a chromatin landscape in embryonic stem cells that is important for proper gene regulation during differentiation.
Data suggest the combination of three genes RPL32 (show RPL32 ELISA Kits), RPS18 (show RPS18 ELISA Kits), and H3F3A is the most suitable for accurate normalization.
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene contains introns and its mRNA is polyadenylated, unlike most histone genes. The protein encoded is a replication-independent member of the histone H3 family.
H3 histone, family 3A
, H3 histone, family 3B (H3.3B)
, H3L-like histone
, histone H3.3
, histone H3.3 variant
, histone H3.3A
, histone variant 3.3
, histone variant H3.3