HECT Domain and Ankyrin Repeat Containing, E3 Ubiquitin Protein Ligase 1 (HACE1) ELISA Kits

E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Additionally we are shipping HACE1 Antibodies (38) and HACE1 Proteins (4) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
HACE1 57531 Q8IYU2
HACE1 209462 Q3U0D9
HACE1 361866 D3ZBM7
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Top HACE1 ELISA Kits at antibodies-online.com

Showing 5 out of 12 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 6.25 pg/mL 25-1600 pg/mL Typical standard curve 96 Tests Log in to see 15 to 18 Days
$910.56
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Mouse
  96 Tests Log in to see 11 to 18 Days
$589.86
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Rat
  96 Tests Log in to see 11 to 18 Days
$589.86
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Cow
  96 Tests Log in to see 15 to 18 Days
$1,029.60
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Chicken
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$1,095.60
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More ELISA Kits for HACE1 Interaction Partners

Human HECT Domain and Ankyrin Repeat Containing, E3 Ubiquitin Protein Ligase 1 (HACE1) interaction partners

  1. A functional interplay between HACE1 and Rac1 in cancer, is reported.

  2. Results identified HACE1 Ser-385 as a pivotal amino acid residue that is phosphorylated in response to CNF1 or VEGF treatments and that expression of activated Rac1 is sufficient to induce HACE1 phosphorylation and controlling its oligomerization state.

  3. Results indicated that HACE1 rs9404576 polymorphism may be associated with Wilms' tumor susceptibility in the Chinese population.

  4. 3-deazaneplanocin A treatment increased HACE1 gene expression which was further increased by the addition of trichostatine A (TSA), a promising therapeutic compound for the treatment of human B-Lymphoma

  5. Mechanistic studies showed that HACE1 exerts its inhibitory role on virus-induced signaling by disrupting the MAVS-TRAF3 complex.

  6. HACE1 can act as a haploinsufficient tumor suppressor gene in most B-cell lymphomas and can be downregulated by deacetylation of its promoter region chromatin

  7. Hepatocellular carcinoma patients with low HACE1 expression levels exhibited poorer overall survival and HACE1 was found to be an independent prognostic factor for survival.

  8. HACE1 as a specific E3 ligase that polyubiquitinates YB-1 through non-canonical K27 linked ubiquitin chains.

  9. Biallelic loss-of-function mutations in HACE1 are associated with an autosomal recessive neurodevelopmental syndrome.

  10. supports a critical role for HACE1 in breast cancer progression and identifies patients that may benefit from Rac-targeted therapies

  11. contrary to previous report, overexpression of HACE1 by transduction of recombinant protein did not affect proliferation or survival of NKTCL cell lines. We therefore conclude that HACE1 is not directly involved in NKTCL pathophysiology

  12. HACE1-OPTN axis synergistically suppresses growth and tumorigenicity of lung cancer cells.

  13. Ubiquitylation and activation of RAB11a is promoted by a beta2 adrenergic receptor-HACE1 complex.

  14. HACE1 reduces oxidative stress and mutant Huntingtin toxicity by promoting the NRF2 response.

  15. All stages of HCCs presented HACE1 methylation, indicating that the HACE1 gene has been methylated from the early stages of HCCs.

  16. HACE1 is tumor suppressor gene located within the 6q21 region, and loss of function of multiple tumor suppressor genes within 6q21 may be a critical determinant of NK cell lymphomagenesis.

  17. HACE1 is an antagonist of cell migration through its ability to degrade active Rac1.

  18. common variants in HACE1 and LIN28B influence neuroblastoma susceptibility and indicate that both genes likely have a role in disease progression.

  19. The HACE1 expression increases the ubiquitylation of Rac1, when the GTPase is activated by point mutations or by the GEF-domain of Dbl.

  20. The 6q21-22 region was confirmed as a celiac disease susceptibility locus and harbors multiple independent associations, some of which may implicate ubiquitin-pathways in celiac disease susceptibility, such as mutations in gene HACE1.

Mouse (Murine) HECT Domain and Ankyrin Repeat Containing, E3 Ubiquitin Protein Ligase 1 (HACE1) interaction partners

  1. Authors show that the genetic ablation of hace1 in the YAC128 mouse model of HD accelerates motor deficits and exacerbates cognitive and psychiatric phenotypes in vivo.

  2. HACE1 controls TNF-elicited cell fate decisions and exerts tumor suppressor and anti-inflammatory activities via a TNFR1-RIP3 kinase-necroptosis pathway.

  3. Increased reactive oxygen species (ROS) production due to Hace1 loss leads to glutamine addiction as a mechanism to cope with increased ROS-induced oxidative stress.

  4. Data indicate that HECT E3 ubiquitin ligase HACE1 deficiency accelerates pressure overload-induced heart failure.

  5. HACE1-OPTN axis synergistically suppresses growth and tumorigenicity of lung cancer cells.

  6. Hace1 controls ROS generation of vertebrate Rac1-dependent NADPH oxidase complexes.

HACE1 Antigen Profile

Antigen Summary

E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB (By similarity).

Gene names and symbols associated with HACE1

  • HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 (HACE1) antibody
  • HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 (hace1) antibody
  • HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 L homeolog (hace1.L) antibody
  • HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1 (Hace1) antibody
  • 1700042J16Rik antibody
  • A730034A22Rik antibody
  • BC025474 antibody
  • HACE1 antibody

Protein level used designations for HACE1

HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1 , E3 ubiquitin-protein ligase HACE1 , HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1 , E3 ubiquitin-protein ligase HACE1-like , e3 ubiquitin-protein ligase HACE1-like

GENE ID SPECIES
100071887 Equus caballus
462900 Pan troglodytes
734146 Xenopus (Silurana) tropicalis
100342048 Oryctolagus cuniculus
100399774 Callithrix jacchus
100438368 Pongo abelii
100475389 Ailuropoda melanoleuca
100548893 Meleagris gallopavo
100562508 Anolis carolinensis
100581995 Nomascus leucogenys
446912 Xenopus laevis
421788 Gallus gallus
57531 Homo sapiens
475010 Canis lupus familiaris
100156102 Sus scrofa
527565 Bos taurus
209462 Mus musculus
361866 Rattus norvegicus
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