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E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Additionally we are shipping HACE1 Antibodies (28) and HACE1 Proteins (4) and many more products for this protein.
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Results indicated that HACE1 rs9404576 polymorphism may be associated with Wilms' tumor susceptibility in the Chinese population.
3-deazaneplanocin A treatment increased HACE1 gene expression which was further increased by the addition of trichostatine A (TSA (show PRDX2 ELISA Kits)), a promising therapeutic compound for the treatment of human B-Lymphoma
Mechanistic studies showed that HACE1 exerts its inhibitory role on virus-induced signaling by disrupting the MAVS (show MAVS ELISA Kits)-TRAF3 (show TRAF3 ELISA Kits) complex.
HACE1 can act as a haploinsufficient tumor suppressor gene in most B-cell lymphomas and can be downregulated by deacetylation of its promoter region chromatin
Hepatocellular carcinoma patients with low HACE1 expression levels exhibited poorer overall survival and HACE1 was found to be an independent prognostic factor for survival.
HACE1 as a specific E3 ligase that polyubiquitinates YB-1 through non-canonical K27 linked ubiquitin chains.
Biallelic loss-of-function mutations in HACE1 are associated with an autosomal recessive neurodevelopmental syndrome.
supports a critical role for HACE1 in breast cancer progression and identifies patients that may benefit from Rac (show AKT1 ELISA Kits)-targeted therapies
contrary to previous report, overexpression of HACE1 by transduction of recombinant protein did not affect proliferation or survival of NKTCL cell lines. We therefore conclude that HACE1 is not directly involved in NKTCL pathophysiology
HACE1-OPTN (show OPTN ELISA Kits) axis synergistically suppresses growth and tumorigenicity of lung cancer cells.
HACE1 controls TNF (show TNF ELISA Kits)-elicited cell fate decisions and exerts tumor suppressor and anti-inflammatory activities via a TNFR1 (show TNFRSF1A ELISA Kits)-RIP3 kinase-necroptosis pathway.
Increased reactive oxygen species (ROS (show ROS1 ELISA Kits)) production due to Hace1 loss leads to glutamine (show GFPT1 ELISA Kits) addiction as a mechanism to cope with increased ROS (show ROS1 ELISA Kits)-induced oxidative stress.
Data indicate that HECT E3 ubiquitin ligase HACE1 deficiency accelerates pressure overload-induced heart failure.
Hace1 controls ROS (show ROS1 ELISA Kits) generation of vertebrate Rac1-dependent NADPH oxidase (show NOX1 ELISA Kits) complexes.
E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB (By similarity).
HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1
, E3 ubiquitin-protein ligase HACE1
, HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1
, E3 ubiquitin-protein ligase HACE1-like
, e3 ubiquitin-protein ligase HACE1-like