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The protein encoded by HTATSF1 functions as a cofactor for the stimulation of transcriptional elongation by HIV-1 Tat, which binds to the HIV-1 promoter through Tat-TAR interaction.
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Human Polyclonal HTATSF1 Primary Antibody for ELISA, WB - ABIN451602
Zhou, Deng, Lacoste, Park, Pumfery, Kashanchi, Brady, Kumar: Coordination of transcription factor phosphorylation and histone methylation by the P-TEFb kinase during human immunodeficiency virus type 1 transcription. in Journal of virology 2004
Dog (Canine) Polyclonal HTATSF1 Primary Antibody for WB - ABIN2774210
Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: Large-scale mapping of human protein-protein interactions by mass spectrometry. ... in Molecular systems biology 2007
CA150 (show TCERG1 Antibodies) FF domains recognize multiple sites within the Tat-SF1 protein conforming to the consensus motif (D/E)(2/5)-F/W/Y-(D/E)(2/5).
This study validates Tat-SF1 as an HDF (show Vcan Antibodies) in CD4 (show CD4 Antibodies)+ T cell-derived SupT1 cells.
these findings suggest that Tat-SF1 functions independently in transcription and splicing of cellular genes.
These results support the notion that Tat (show TAT Antibodies)-induced neuropathogenesis is mediated by multiple mechanisms involving both intracellular and extracellular Tat (show TAT Antibodies) protein.
phosphorylated by P-TEFb (show CCNT1 Antibodies) kinase during HIV-1 transcription in Tat (show TAT Antibodies)/TAR (show RBM8A Antibodies) dependent manner
Intracellular HIV-1 Tat (show TAT Antibodies) protein represses constitutive LMP2 (show PSMB9 Antibodies) transcription increasing proteasome activity by interfering with the binding of IRF-1 (show IRF1 Antibodies) to STAT1 (show STAT1 Antibodies)
Tat-SF1 is not required for regulating HIV-1 transcription, but is required for maintaining the ratios of different classes of HIV-1 transcripts.
The protein encoded by this gene functions as a cofactor for the stimulation of transcriptional elongation by HIV-1 Tat, which binds to the HIV-1 promoter through Tat-TAR interaction. This protein may also serve as a dual-function factor to couple transcription and splicing and to facilitate their reciprocal activation. Alternatively spliced transcript variants have been found for this gene.
HIV-1 Tat specific factor 1
, HIV TAT specific factor 1
, HIV Tat-specific factor 1
, HTATSF1 protein
, HIV Tat-specific factor 1 homolog
, cofactor required for Tat activation of HIV-1 transcription