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Huntingtin Antibodies

(Huntingtin (HTT))
Huntingtin is a disease gene linked to Huntington's disease, a neurodegenerative disorder characterized by loss of striatal neurons. This is thought to be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product. A fairly broad range in the number of trinucleotide repeats has been identified in normal controls, and repeat numbers in excess of 40 have been described as pathological. The huntingtin locus is large, spanning 180 kb and consisting of 67 exons. The huntingtin gene is widely expressed and is required for normal development. It is expressed as 2 alternatively polyadenylated forms displaying different relative abundance in various fetal and adult tissues. The larger transcript is approximately 13.7 kb and is expressed predominantly in adult and fetal brain whereas the smaller transcript of approximately 10.3 kb is more widely expressed. The genetic defect leading to Huntington's disease may not necessarily eliminate transcription, but may confer a new property on the mRNA or alter the function of the protein. One candidate is the huntingtin-associated protein-1, highly expressed in brain, which has increased affinity for huntingtin protein with expanded polyglutamine repeats. This gene contains an upstream open reading frame in the 5' UTR that inhibits expression of the huntingtin gene product through translational repression. [provided by RefSeq, Jul 2008].
anti-Huntingtin (HTT) (AA 81-190) antibody anti-Huntingtin (HTT) (AA 81-190) antibody anti-Huntingtin (HTT) (AA 81-190) antibody (ABIN516382)

HTT Reactivity: Human IHC (p), ELISA, WB Host: Mouse Monoclonal 3F1 unconjugated

anti-Huntingtin (HTT) (AA 1150-1200) antibody anti-Huntingtin (HTT) (AA 1150-1200) antibody anti-Huntingtin (HTT) (AA 1150-1200) antibody (ABIN350376)

HTT Reactivity: Mouse, Rat IHC, WB Host: Rabbit Polyclonal unconjugated

anti-Huntingtin (HTT) (AA 81-190) antibody anti-Huntingtin (HTT) (AA 81-190) antibody anti-Huntingtin (HTT) (AA 81-190) antibody (ABIN561241)

HTT Reactivity: Human IF, ELISA, WB Host: Mouse Monoclonal 2E10 unconjugated

Huntingtin Antibodies by Reactivity

Find Huntingtin Antibodies for a variety of species such as anti-Human Huntingtin, anti-Rat Huntingtin, anti-Mouse Huntingtin. The species listed below are among those available. Click on a link to go to the corresponding products.

Huntingtin Antibodies by Application

Find Huntingtin Antibodies validated for a specific application such as WB, ELISA, IHC, IHC (p). Some of the available applications are listed below. Click on a link to go to the corresponding products.

Huntingtin Antibodies by Host

Find Huntingtin Antibodies with a specific Host. The Host listed below are among those available. Click on a link to go to the corresponding products.

Huntingtin Antibodies by Binding Specificity

Find Huntingtin Antibodies with a specific epitope. The epitopes listed below are among those available. Click on a link to go to the corresponding products.

Huntingtin Antibodies by Clonality

Find available monoclonal or polyclonal Huntingtin Antibodies. Click on a link to go to the corresponding products.

Huntingtin Antibodies by Clone

Find Huntingtin Antibodies with a specific Clone. The Clone listed below are among those available. Click on a link to go to the corresponding products.

Huntingtin Antibodies by Conjugate

Find Huntingtin Antibodies with a specific conjugate such as Alexa Fluor 488, Alexa Fluor 555, Alexa Fluor 594. The conjugates listed below are among those available. Click on a link to go to the corresponding products.

Popular Huntingtin Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application ELISA, WB
Validations
  • (1)
  • (2)
Cat. No. ABIN516379
Quantity 100 μg
Datasheet Datasheet

Application IF, IHC (p), WB
Validations
  • (1)
  • (1)
Cat. No. ABIN6254174
Quantity 600 μg
Datasheet Datasheet
Reactivity Human
Application IHC, ELISA, WB
Validations
  • (2)
Cat. No. ABIN100604
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rabbit
Application IHC (fro), IP, WB
Validations
  • (2)
  • (1)
Cat. No. ABIN2474102
Quantity 0.1 mg
Datasheet Datasheet
Reactivity Human
Application ELISA, WB
Validations
  • (2)
Cat. No. ABIN516380
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Rabbit
Application IHC, IHC (fro), IHC (p), IP, WB
Validations
  • (2)
Cat. No. ABIN790678
Quantity 50 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application FM, IHC, ELISA, WB
Validations
  • (1)
Cat. No. ABIN1607890
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (1)
Cat. No. ABIN3042565
Quantity 100 μg
Datasheet Datasheet
Reactivity Rat
Application ELISA, ICC, IF (cc), IF (p), IHC (fro), IHC (p)
Validations
  • (1)
Cat. No. ABIN1387692
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, WB
Validations
  • (1)
Cat. No. ABIN6262422
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, WB
Validations
  • (1)
Cat. No. ABIN561240
Quantity 50 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, WB
Validations
  • (1)
Cat. No. ABIN516383
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application IF, ELISA
Validations
  • (1)
Cat. No. ABIN516386
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application IHC (p), ELISA, WB
Validations
  • (1)
Cat. No. ABIN1735629
Quantity 50 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rabbit
Application IHC (fro), IP, WB
Validations
  • (1)
Cat. No. ABIN119306
Quantity 0.1 mg
Datasheet Datasheet

Latest Publications for our Huntingtin Antibodies

Meunier, Merienne, Jollé, Déglon, Pellerin: "Astrocytes are key but indirect contributors to the development of the symptomatology and pathophysiology of Huntington's disease." in: Glia, Vol. 64, Issue 11, pp. 1841-56, (2018) (PubMed).

Yao, Cui, Al-Ramahi, Sun, Li, Hou, Difiglia, Palacino, Wu, Ma, Botas, Lu: "A striatal-enriched intronic GPCR modulates huntingtin levels and toxicity." in: eLife, Vol. 4, (2015) (PubMed).

Shirasaki, Greiner, Al-Ramahi, Gray, Boontheung, Geschwind, Botas, Coppola, Horvath, Loo, Yang: "Network organization of the huntingtin proteomic interactome in mammalian brain." in: Neuron, Vol. 75, Issue 1, pp. 41-57, (2012) (PubMed).

Parker, Vazquez-Manrique, Tourette, Farina, Offner, Mukhopadhyay, Orfila, Darbois, Menet, Tissenbaum, Neri: "Integration of ?-catenin, sirtuin, and FOXO signaling protects from mutant huntingtin toxicity." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 32, Issue 36, pp. 12630-40, (2012) (PubMed).

Thompson, Aiken, Kaltenbach, Agrawal, Illes, Khoshnan, Martinez-Vincente, Arrasate, ORourke, Khashwji, Lukacsovich, Zhu, Lau, Massey, Hayden, Zeitlin, Finkbeiner, Green, LaFerla, Bates, Huang et al.: "IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome. ..." in: The Journal of cell biology, Vol. 187, Issue 7, pp. 1083-99, (2009) (PubMed).

Imarisio, Carmichael, Korolchuk, Chen, Saiki, Rose, Krishna, Davies, Ttofi, Underwood, Rubinsztein: "Huntington's disease: from pathology and genetics to potential therapies." in: The Biochemical journal, Vol. 412, Issue 2, pp. 191-209, (2008) (PubMed).

Hall, Georgel: "CHD proteins: a diverse family with strong ties." in: Biochemistry and cell biology = Biochimie et biologie cellulaire, Vol. 85, Issue 4, pp. 463-76, (2007) (PubMed).

Vonsattel: "Huntington disease models and human neuropathology: similarities and differences." in: Acta neuropathologica, Vol. 115, Issue 1, pp. 55-69, (2007) (PubMed).

Lee, Yoshihara, Littleton: "Cytoplasmic aggregates trap polyglutamine-containing proteins and block axonal transport in a Drosophila model of Huntington's disease." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 9, pp. 3224-9, (2004) (PubMed).

Zainelli, Ross, Troncoso, Fitzgerald, Muma: "Calmodulin regulates transglutaminase 2 cross-linking of huntingtin." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 24, Issue 8, pp. 1954-61, (2004) (PubMed).

Aliases for Huntingtin Antibodies

huntingtin (HTT) Antibodies
huntingtin (htt) Antibodies
huntingtin (LOC373520) Antibodies
huntingtin (Htt) Antibodies
AI256365 Antibodies
C430023I11Rik Antibodies
CG9995 Antibodies
dHtt Antibodies
dhtt Antibodies
Dmel\\CG9995 Antibodies
hd Antibodies
HD Antibodies
Hd Antibodies
Hdh Antibodies
Hsap\\HD Antibodies
HTT Antibodies
Htt Antibodies
htt Antibodies
huntington Antibodies
it15 Antibodies
IT15 Antibodies
SLC6A4 Antibodies
ZHD Antibodies
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