Heat Shock 105kDa/110kDa Protein 1 Proteins (HSPH1)

Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Additionally we are shipping Heat Shock 105kDa/110kDa Protein 1 Antibodies (168) and Heat Shock 105kDa/110kDa Protein 1 Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HSPH1 288444 Q66HA8
HSPH1 10808 Q92598
HSPH1 15505 Q61699
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Top Heat Shock 105kDa/110kDa Protein 1 Proteins at antibodies-online.com

Showing 8 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$13,741.67
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$13,741.67
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 11 Days
$888.80
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
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Escherichia coli (E. coli) Human His tag   100 μg Log in to see 15 to 18 Days
$448.00
Details
Escherichia coli (E. coli) Rat His tag   100 μg Log in to see 15 to 18 Days
$544.00
Details
Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 11 Days
$364.64
Details
Human Un-conjugated   1 mg Log in to see 6 to 8 Days
$3,283.50
Details

HSPH1 Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus)

Human , , ,
, ,
Mouse (Murine)

Top referenced Heat Shock 105kDa/110kDa Protein 1 Proteins

  1. Human HSPH1 Protein expressed in HEK-293 Cells - ABIN2722568 : Berthenet, Boudesco, Collura, Svrcek, Richaud, Hammann, Causse, Yousfi, Wanherdrick, Duplomb, Duval, Garrido, Jego: Extracellular HSP110 skews macrophage polarization in colorectal cancer. in Oncoimmunology 2016 (PubMed)

More Proteins for Heat Shock 105kDa/110kDa Protein 1 (HSPH1) Interaction Partners

Xenopus laevis Heat Shock 105kDa/110kDa Protein 1 (HSPH1) interaction partners

  1. These studies demonstrate that Xenopus hsp110 gene expression is constitutive and stress inducible in cultured cells and developmentally- and tissue specifically-regulated during early embryogenesis[hsp110]

Human Heat Shock 105kDa/110kDa Protein 1 (HSPH1) interaction partners

  1. expression not an independent prognostic factor in gastric cancer patients with peritoneal metastasis, but might be a new marker of chemosensitivity

  2. Established heat shock protein 110 (HSP110) as a prognostic biomarker of colorectal carcinomas (CRCs) with microsatellite instability-high (MSI-H) by considering the intratumoral heterogeneity of HSP110 expression. The HSP110wt-low MSI-H CRCs were significantly correlated with larger deletions in the HSP110 T17 mononucleotide repeat (>/=4 bp; p < 0.001).

  3. HSP110 HT17 alone correctly classified samples judged to be uncertain with the pentaplex panel.

  4. deletion of the HSP110 T17 repeat was frequently observed in microsatellite-unstable advanced gastric cancers.

  5. Hsp105alpha localizes to the nucleus, interacts with HIF-1alpha and induces HIF-1a accumulation in CoCl2-treated cells.

  6. the expression of HSP110 in colon cancer contributes to STAT3-dependent tumor growth

  7. About 25% of patients with stages II-III colorectal tumors with microsatellite instability have an excellent response to chemotherapy, due to large, biallelic deletions in the T(17) intron repeat of HSP110 in tumor DNA.

  8. HSP105 depletion disrupts the integration of protein phosphatase 2A into the beta-catenin degradation complex, favoring the hyperphosphorylation and degradation of beta-catenin.

  9. A receiver operating characteristic curve constructed with HSP105 and TIM gave a sensitivity of 54.3% and 95% (38/40) specificity in discriminating esophageal squamous cell carcinoma from matched controls.

  10. we measured the binding of human Hsp72 (HSPA1A) to BAG1, BAG2, BAG3, and the unrelated NEF Hsp105. These studies revealed a clear hierarchy of affinities: BAG3 > BAG1 > Hsp105 >> BAG2.

  11. HSPH1 and HSPH2 are bona fide chaperones on their own that collaborate with DNAJA1 and DNAJB1 to hydrolyze ATP and unfold polypeptides and HSPA1A and HSPH1 formed a powerful molecular machinery.

  12. High HSP105 expression is associated with Barrett's esophagus.

  13. It restricts aggregation of denaturated proteins,plays a role in protein folding in cytoplasms,and enhance expression of hsp70 in cell nucleus.(review)

  14. The Hsp105-mediated multilevel regulation of DeltaF508 CFTR folding and quality control provides new opportunities to understand how chaperone machinery regulates the homeostasis and functional expression of misfolded proteins in the cell.

  15. A direct correlation between HSP105 expression and lymphoma aggressiveness was also apparent.

  16. Hsp105alpha and Hsp105beta suppressed the expanded polyQ tract-induced protein aggregation and apoptosis through the induction of Hsp70.

  17. Heat shock protein 105 is overexpressed in a variety of human tumors

  18. HSP105 appears to chaperone the responses to endoplasmic reticulum (ER) stress through its interactions with GRP78 and GSK3, and without HSP105 cell death following ER stress proceeds by a non-caspase-3-dependent process.

  19. HSP105 analysis may be a helpful tool as a poor prognostic indicator and as a diagnostic aid in problematic lesions.

  20. HSP 105 is thought to be a more relevant tumor-associated antigen in malignant melanoma than is HSP 70.

Mouse (Murine) Heat Shock 105kDa/110kDa Protein 1 (HSPH1) interaction partners

  1. These observations suggest that GGA administration is a therapeutic candidate for depressive diseases by increasing hippocampal BDNF levels via HSP105 expression.

  2. Hsp105 may play an important role in the refolding of denatured proteins and protection against stress-induced cell death in mammalian cells.

  3. Hsp110 over-expression increases the immunogenicity of the murine CT26 colon tumor.

  4. Data suggest that Hsp105 has opposite effects on stress-induced apoptosis depending on the cell type; a pro-apoptotic effect in embryonal cells and an anti-apoptotic effect in neuronal cells.

  5. enhances activation of p38, release of cytochrome c and caspase activation; may play important roles in organogenesis, during which marked apoptosis occurs, by enhancing apoptosis during mouse embryogenesis

  6. Hsp105alpha is suggested to regulate the substrate binding cycle of Hsp70/Hsc70 by inhibiting the ATPase activity of Hsp70/Hsc70, thereby functioning as a negative regulator of the Hsp70/Hsc70 chaperone system.

  7. The constitutive overexpression of HSP105 in cancer cells is involved in malignant transformation by protecting tumor cells from apoptosis.

  8. it is suggested that Hsp105 suppresses the stress-induced apoptosis at its initial step, the translocation of Bax to mitochondria

  9. HSP105 appears to chaperone the responses to endoplasmic reticulum (ER) stress through its interactions with GRP78 and GSK3, and without HSP105 cell death following ER stress proceeds by a non-caspase-3-dependent process.

  10. hsp110/105 KO mice are resistant to ischemic injury and that the protective effects of hsp110/105 deficiency in cerebral ischemia may partly be mediated by an increase in the chaperone activity of Hsp70.

Heat Shock 105kDa/110kDa Protein 1 (HSPH1) Protein Profile

Protein Summary

Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (By similarity).

Gene names and symbols associated with HSPH1

  • heat shock protein family H (Hsp110) member 1 (hsph1)
  • heat shock protein family H (Hsp110) member 1 S homeolog (hsph1.S)
  • heat shock protein family H (Hsp110) member 1 (HSPH1)
  • heat shock protein 105 kDa (LOC100546590)
  • heat shock protein family H (Hsp110) member 1 (Hsph1)
  • heat shock 105kDa/110kDa protein 1 (Hsph1)
  • heat shock protein family H (Hsp110) member 1 L homeolog (hsph1.L)
  • 105kDa protein
  • AI790491 protein
  • hsp-E7I protein
  • HSP105 protein
  • HSP105A protein
  • HSP105B protein
  • Hsp110 protein
  • hsph1 protein
  • hsph1a protein
  • hsph1b protein
  • NY-CO-25 protein

Protein level used designations for HSPH1

heat shock 105kD , heat shock protein 105 , heat shock 105kDa/110kDa protein 1b , heat shock 105kDa/110kDa protein 1 , heat shock protein 105 kDa-like , heat shock 105kDa , heat shock 110 kDa protein , heat shock protein 105 kDa , antigen NY-CO-25 , heat shock 105kD alpha , heat shock 105kD beta , heat shock 105kDa protein 1 , 42 degrees C-HSP , HSP105 42 C-HSP , heat shock protein 110 , heat shock protein, 105 kDa , heat shock-related 100 kDa protein E7I , heat shock 105kDa/110kDa protein 1a

GENE ID SPECIES
394775 Xenopus (Silurana) tropicalis
446527 Xenopus laevis
452522 Pan troglodytes
477322 Canis lupus familiaris
721956 Macaca mulatta
100062150 Equus caballus
100352543 Oryctolagus cuniculus
100394735 Callithrix jacchus
100466800 Ailuropoda melanoleuca
100546590 Meleagris gallopavo
100599947 Nomascus leucogenys
288444 Rattus norvegicus
10808 Homo sapiens
15505 Mus musculus
444063 Xenopus laevis
418917 Gallus gallus
100048931 Sus scrofa
507165 Bos taurus
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