Heat Shock 22kDa Protein 8 (HSPB8) ELISA Kits

The protein encoded by HSPB8 belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human HSPB8 HSPB8 26353 Q9UJY1
Anti-Mouse HSPB8 HSPB8 80888 Q9JK92
Anti-Rat HSPB8 HSPB8 113906 Q9EPX0
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Top Heat Shock 22kDa Protein 8 ELISA Kits at antibodies-online.com

Showing 3 out of 12 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 0.058 ng/mL 0.15 ng/mL - 10 ng/mL 96 Tests Log in to see 13 to 16 Days
$736.84
Details
Mouse 0.059 ng/mL 0.15 ng/mL - 10 ng/mL 96 Tests Log in to see 13 to 16 Days
$757.89
Details
Rat 0.59 ng/mL 1.56 ng/mL - 100 ng/mL 96 Tests Log in to see 13 to 16 Days
$800.00
Details

More ELISA Kits for Heat Shock 22kDa Protein 8 Interaction Partners

Human Heat Shock 22kDa Protein 8 (HSPB8) interaction partners

  1. HSPB2 (show HSPB2 ELISA Kits) competes with HSPB8 for binding to BAG3 (show BAG3 ELISA Kits). In contrast, HSPB3 (show HSPB3 ELISA Kits) negatively regulates HSPB2 (show HSPB2 ELISA Kits) association with BAG3 (show BAG3 ELISA Kits).

  2. Silencing of HSPB8 markedly decreased the mitotic levels of BAG3 in HeLa cells, supporting its crucial role in BAG3 mitotic functions. The results support a role for the HSPB8-BAG3 chaperone complex in quality control of actin-based structure dynamics that are put under high tension, notably during cell cytokinesis.

  3. HSPB8 is involved in regulating the cell cycle and cell migration in MCF-7 cells.

  4. suggest that HSPB8 may act as an intracellular factor against hepatitis C virus replication and that DNAJC5B has the same function, with more relevant results for genotype 3

  5. It has been demonstrated that HSPB8-BAG3 (show BAG3 ELISA Kits)-HSP70 (show HSP70 ELISA Kits) ensures the functionality of stress granules and restores proteostasis by targeting defective ribosomal products for degradation.

  6. We report that overexpression of HSPB8 in immortalized motor neurones decreased the accumulation of TDP-25 and TDP-35 and that protection against mislocalized/truncated TDP-43 (show TARDBP ELISA Kits) was observed for HSPB8 in Drosophila melanogaster Overexpression of HSP67Bc, the functional ortholog of human HSPB8, suppressed the eye degeneration caused by the cytoplasmic accumulation of a TDP-43 (show TARDBP ELISA Kits) variant

  7. HSPB8 counteracts accumulation of aberrantly localized misfolded forms of TDP-43 (show TARDBP ELISA Kits) and its 25 KDa fragment involved in most sporadic cases of Amyotrophic Lateral Sclerosis and of Fronto Lateral Temporal Dementia.

  8. expands the understanding of disease mechanisms, tissue involvement, and phenotypic outcome of HSPB8 mutations

  9. our findings suggest the existence of a so-far unrecognized quality control mechanism involving BAG3 (show BAG3 ELISA Kits), HSPB8 and p62/SQSTM1 (show SQSTM1 ELISA Kits) for accurate remodelling of actin-based mitotic structures that guide spindle orientation.

  10. This study demonstreated that expression of HSPB8 was restricted to GFAP (show GFAP ELISA Kits)+ astrocytes in patient with multiple sclerosis.

Cow (Bovine) Heat Shock 22kDa Protein 8 (HSPB8) interaction partners

  1. GA genotype of SNP g.507G>A of HSPB8 gene has a probable role in heat tolerance in Sahiwal cattle.

Mouse (Murine) Heat Shock 22kDa Protein 8 (HSPB8) interaction partners

  1. HSP22 functions as a negative regulator in the TGF-beta (show TGFB1 ELISA Kits)-stimulated migration of osteoblasts.

  2. Results revealed that the apoptosis-suppressing effect of heat shock protein B8 was mediated by the PI3K/Akt (show AKT1 ELISA Kits) pathway in an in vitro model of ischemia.

  3. Increased Hsp20 (show HSPB6 ELISA Kits) expression protects against OGDR-induced Golgi fragmentation and apoptosis, likely through interaction with Bax (show BAX ELISA Kits) and subsequent amelioration of the OGDR-induced elevation in p115 cleavage via the Fas (show FAS ELISA Kits)/FasL (show FASL ELISA Kits) signaling pathway.

  4. Translocation of both Hsp22 and iNOS to the mitochondria is necessary for Hsp22-mediated stimulation of oxidative phosphorylation

  5. analysis of the phenotype of cardiomyopathy in cardiac-specific heat shock protein B8 K141N transgenic mouse

  6. The results of this study strongly suggested that Hspb8 and its alpha-crystallin domain might act as pleiotropic prosurvival factor in the adult hippocampus.

  7. Hspb8 mRNA is constitutively expressed in specific brain structures across ontogeny; eventually these structures could be affected by the malfunction or deregulation of the Hspb8 molecule.

  8. Hsp22 represents a previously undescribed activator of both nuclear and mitochondrial functions of STAT3 (show STAT3 ELISA Kits), and its deletion in the context of pressure overload in vivo accelerates the transition into heart failure and increases mortality.

  9. HspB8 increases misfolded SOD1 (show SOD1 ELISA Kits) clearance via autophagy.

  10. Findings show that despite the ubiquitous presence of HSPB8, only motor neurons appear to be affected by the K141N and K141E mutations.

Heat Shock 22kDa Protein 8 (HSPB8) Antigen Profile

Antigen Summary

The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, this gene appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease.

Gene names and symbols associated with HSPB8

  • heat shock protein family B (small) member 8 L homeolog (hspb8.L) antibody
  • heat shock protein family B (small) member 8 (HSPB8) antibody
  • heat shock protein b8 (hspb8) antibody
  • heat shock protein 8 (Hspb8) antibody
  • heat shock protein family B (small) member 8 (Hspb8) antibody
  • AU018630 antibody
  • AW413033 antibody
  • CMT2L antibody
  • Cryac antibody
  • D5Ucla4 antibody
  • DHMN2 antibody
  • E2IG1 antibody
  • fc09c11 antibody
  • H11 antibody
  • H11K antibody
  • HMN2 antibody
  • HMN2A antibody
  • HSP20-like antibody
  • Hsp22 antibody
  • MGC64408 antibody
  • wu:fc04b04 antibody
  • wu:fc09c11 antibody
  • zgc:64202 antibody

Protein level used designations for HSPB8

heat shock 22kDa protein 8 , heat shock 27kDa protein 8 , heat shock protein beta-8 , E2-induced gene 1 protein , alpha-crystallin C chain , protein kinase H11 , small stress protein-like protein HSP22 , H11 kinase , crystallin, alpha C , heat shock protein 20-like protein , heat shock protein 8

GENE ID SPECIES
379472 Xenopus laevis
416988 Gallus gallus
452295 Pan troglodytes
100174469 Pongo abelii
100349029 Oryctolagus cuniculus
791580 Danio rerio
26353 Homo sapiens
403553 Canis lupus familiaris
539524 Bos taurus
574341 Macaca mulatta
80888 Mus musculus
113906 Rattus norvegicus
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