Heat Shock 22kDa Protein 8 (HSPB8) ELISA Kits

The protein encoded by HSPB8 belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. Additionally we are shipping Heat Shock 22kDa Protein 8 Antibodies (233) and Heat Shock 22kDa Protein 8 Proteins (26) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
HSPB8 26353 Q9UJY1
HSPB8 80888 Q9JK92
HSPB8 113906 Q9EPX0
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Top Heat Shock 22kDa Protein 8 ELISA Kits at antibodies-online.com

Showing 3 out of 15 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 0.058 ng/mL 0.15 ng/mL - 10 ng/mL 96 Tests Log in to see 13 to 16 Days
Mouse 0.059 ng/mL 0.15 ng/mL - 10 ng/mL 96 Tests Log in to see 13 to 16 Days
Rat 0.59 ng/mL 1.56 ng/mL - 100 ng/mL 96 Tests Log in to see 13 to 16 Days

More ELISA Kits for Heat Shock 22kDa Protein 8 Interaction Partners

Human Heat Shock 22kDa Protein 8 (HSPB8) interaction partners

  1. HSPB8 binds BAG3 to promote spatial sequestration of ubiquitinated proteins.

  2. results strongly suggest that HSP22 represses HCC progression, especially HCC cell migration, by the down-regulation of the PI3K/AKT signaling pathway.

  3. We identified impaired RNA metabolism, secondary to TDP-43 loss of function, as a possible pathological mechanism of HSPB8 toxicity, leading to muscle and nerve degeneration

  4. Data indicated that the HSPB8 expression level was strongly positively correlated with MAPK signaling pathway and CREB pathway and worse prognosis. The methylation level of its DNA was negatively associated with its expression and positively associated with overall survival. These results suggest that HSPB8 could promote the proliferation and inhibit the apoptosis of GC cells by activating ERKCREB signaling.

  5. HSPB2 competes with HSPB8 for binding to BAG3. In contrast, HSPB3 negatively regulates HSPB2 association with BAG3.

  6. Silencing of HSPB8 markedly decreased the mitotic levels of BAG3 in HeLa cells, supporting its crucial role in BAG3 mitotic functions. The results support a role for the HSPB8-BAG3 chaperone complex in quality control of actin-based structure dynamics that are put under high tension, notably during cell cytokinesis.

  7. HSPB8 is involved in regulating the cell cycle and cell migration in MCF-7 cells.

  8. suggest that HSPB8 may act as an intracellular factor against hepatitis C virus replication and that DNAJC5B has the same function, with more relevant results for genotype 3

  9. It has been demonstrated that HSPB8-BAG3-HSP70 ensures the functionality of stress granules and restores proteostasis by targeting defective ribosomal products for degradation.

  10. We report that overexpression of HSPB8 in immortalized motor neurones decreased the accumulation of TDP-25 and TDP-35 and that protection against mislocalized/truncated TDP-43 was observed for HSPB8 in Drosophila melanogaster Overexpression of HSP67Bc, the functional ortholog of human HSPB8, suppressed the eye degeneration caused by the cytoplasmic accumulation of a TDP-43 variant

  11. HSPB8 counteracts accumulation of aberrantly localized misfolded forms of TDP-43 and its 25 KDa fragment involved in most sporadic cases of Amyotrophic Lateral Sclerosis and of Fronto Lateral Temporal Dementia.

  12. expands the understanding of disease mechanisms, tissue involvement, and phenotypic outcome of HSPB8 mutations

  13. our findings suggest the existence of a so-far unrecognized quality control mechanism involving BAG3, HSPB8 and p62/SQSTM1 for accurate remodelling of actin-based mitotic structures that guide spindle orientation.

  14. This study demonstreated that expression of HSPB8 was restricted to GFAP+ astrocytes in patient with multiple sclerosis.

  15. Pangenomic profiling of velcade-sensitive and resistant cells showed that the small heat shock protein HSPB8 was overexpressed in multiple myeloma resistant cells.

  16. HSP22 acts as a positive regulator in TGF-alpha-induced migration of ovarian cancer cells, subsequently directing ovarian cancer toward progression.

  17. HSP22 plays an important role on gastric tumor aggressiveness and prognosis and may act as a promising target for prognostic prediction.

  18. Mutant HSPB8 causes protein aggregates and a reduced mitochondrial membrane potential in dermal fibroblasts from distal hereditary motor neuropathy patients.

  19. The expression of HspB8 inhibits the growth of genetically diverse melanoma cells that include caspase-1 activation outside of the realm of the inflammasome, mTORC1-dependent Beclin-1 upregulation and its cleavage by the activated caspase-1.

  20. findings show that during heat shock recovery NF-kappaB activates selective removal of misfolded or aggregated proteins by controlling expression of BAG3 and HSPB8 and by modulating the level of the BAG3-HspB8 complex

Cow (Bovine) Heat Shock 22kDa Protein 8 (HSPB8) interaction partners

  1. GA genotype of SNP g.507G>A of HSPB8 gene has a probable role in heat tolerance in Sahiwal cattle.

Mouse (Murine) Heat Shock 22kDa Protein 8 (HSPB8) interaction partners

  1. These results strongly suggest that HSP22 interacts with mTOR and regulates TNF-alpha-induced IL-6 synthesis in osteoblasts.

  2. HSP22 functions as a negative regulator in the TGF-beta-stimulated migration of osteoblasts.

  3. Results revealed that the apoptosis-suppressing effect of heat shock protein B8 was mediated by the PI3K/Akt pathway in an in vitro model of ischemia.

  4. Increased Hsp20 expression protects against OGDR-induced Golgi fragmentation and apoptosis, likely through interaction with Bax and subsequent amelioration of the OGDR-induced elevation in p115 cleavage via the Fas/FasL signaling pathway.

  5. Translocation of both Hsp22 and iNOS to the mitochondria is necessary for Hsp22-mediated stimulation of oxidative phosphorylation

  6. analysis of the phenotype of cardiomyopathy in cardiac-specific heat shock protein B8 K141N transgenic mouse

  7. The results of this study strongly suggested that Hspb8 and its alpha-crystallin domain might act as pleiotropic prosurvival factor in the adult hippocampus.

  8. Hspb8 mRNA is constitutively expressed in specific brain structures across ontogeny; eventually these structures could be affected by the malfunction or deregulation of the Hspb8 molecule.

  9. protection of mitochondrial function during ischemia via NO-sensitive mechanism

  10. Hsp22 represents a previously undescribed activator of both nuclear and mitochondrial functions of STAT3, and its deletion in the context of pressure overload in vivo accelerates the transition into heart failure and increases mortality.

  11. HspB8 increases misfolded SOD1 clearance via autophagy.

  12. Findings show that despite the ubiquitous presence of HSPB8, only motor neurons appear to be affected by the K141N and K141E mutations.

  13. H11 kinase promotes the synthesis of glycogen, an essential fuel for the stressed heart in both conditions of overload and ischemia

  14. Hsp22-mediated cardiac hypertrophy promotes an increased expression and activity, and a subcellular redistribution of the proteasome.

Heat Shock 22kDa Protein 8 (HSPB8) Antigen Profile

Antigen Summary

The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, this gene appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease.

Gene names and symbols associated with HSPB8

  • heat shock protein family B (small) member 8 (HSPB8) antibody
  • heat shock protein family B (small) member 8 L homeolog (hspb8.L) antibody
  • heat shock protein 8 (hspa8) antibody
  • heat shock protein b8 (hspb8) antibody
  • heat shock protein 8 (Hspb8) antibody
  • heat shock protein family B (small) member 8 (Hspb8) antibody
  • AU018630 antibody
  • AW413033 antibody
  • CMT2L antibody
  • Cryac antibody
  • D5Ucla4 antibody
  • DHMN2 antibody
  • E2IG1 antibody
  • fc09c11 antibody
  • H11 antibody
  • H11K antibody
  • HMN2 antibody
  • HMN2A antibody
  • hsc70 antibody
  • HSP20-like antibody
  • Hsp22 antibody
  • MGC64408 antibody
  • wu:fb01g06 antibody
  • wu:fc04b04 antibody
  • wu:fc09c11 antibody
  • wu:fi48b06 antibody
  • zgc:64202 antibody

Protein level used designations for HSPB8

E2-induced gene 1 protein , alpha-crystallin C chain , heat shock 27kDa protein 8 , heat shock protein beta-8 , protein kinase H11 , small stress protein-like protein HSP22 , heat shock 22kDa protein 8 , H11 kinase , heat shock 70 kDa protein 8 , heat shock 70kDa protein 8 , heat shock cognate 71 kDa protein , heat shock cognate 71-kd protein , crystallin, alpha C , heat shock protein 20-like protein , heat shock protein 8

26353 Homo sapiens
379472 Xenopus laevis
403553 Canis lupus familiaris
416988 Gallus gallus
452295 Pan troglodytes
539524 Bos taurus
574341 Macaca mulatta
100174469 Pongo abelii
100349029 Oryctolagus cuniculus
573376 Danio rerio
791580 Danio rerio
80888 Mus musculus
113906 Rattus norvegicus
100734199 Cavia porcellus
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