Heat Shock 70kDa Protein 1B (HSPA1B) ELISA Kits

Human Heat Shock 70kDa Protein 1B (HSPA1B) interaction partners

1. Data show that HSPA1B exerts a positive effect on hepatocellular carcinoma (HCC) cell growth and may be involved in the HBV-miR- 340- 5p- ATF7 axis.

2. the presence of HSPA1B 1267GG genotype significantly increases the risk of glaucoma in northern Iran

3. Downregulation of HSPA1b impaired mesenchymal stem cell osteogenic and chondrogenic differentiation.

4. Heat shock protein 70-2 (HSP70-2) expression was detected in 78 % of colorectal cancer (CRC) patients.

5. The rs2763979 locus of the HSP70 genes may be associated with susceptibility to noise-induced hearing loss (NIHL) in Chinese individuals, and other HSP70 genes may also be susceptibility genes for NIHL, but the results must be further replicated in additional independent sample sets.

6. HSPA1B was down-regulated in atrial fibrillation subjects who suffered a stroke.

7. The 1267HSP70-2 polymorphism is associated with obesity in an Iranian population, supporting a possible potential genetic link between obesity and cardiovascular diseases.

8. Polymorphism of HSP70 A1B gene is associated with the development of esophageal Carcinoma.

9. HSPA1B (rs1061581) is associated with a decreased risk of idiopathic pulmonary fibrosis in a Mexican population.

10. Lysine methylation of HSPA1 differs between metastatic breast and ovarian carcinoma.

11. Infertility in males with normal sperm parameters was not significantly associated with HSPA1B:c.1059G>A gene polymorphism.

12. The G allele of the HSP70-2 A+1267G polymorphism confers survival advantages in non-diabetic peritoneal dialysis patients

13. This meta-analysis suggests associations between the HSPA1B +/-1267A/G polymorphism and risk of cancer.

14. HSPA1B A1267G polymorphism is a marker of susceptibility to peptic ulcer in the Iranian population.

15. The A allele of the HSP70-2 PstI polymorphism was associated with enterocutaneous fistulas in this Chinese population.

16. HSP70-2 plays a key role in cancerous growth and invasive potential of RCC cells.

17. genetic polymorphism is associated with Alopecia Areata in Korean population

18. The potential implication of HSPA1A +190G/C, HSPA1B +1267A/G, and HSPA1L +2437T/C polymorphisms in the susceptibility to paranoid schizophrenia in a homogenous Caucasian Polish population, was analyzed.

19. The expression of HSP70-1A and HSP70-1B in T-lymphocytes and monocytes from multiple sclerosis patients under basal conditions was up-regulated that may reflect the immunological activation occurring in these patients.

20. HSPA1B 1267 A/A genotype seems to have a protective role against cataract and the G allele does not seem to have a deleterious role in the development of cataract.

Arabidopsis thaliana Heat Shock 70kDa Protein 1B (HSPA1B) interaction partners

1. Here, the authors determined crystal structures of AtBAG5 alone and in complex with Ca(2+)-free CaM. Structural and biochemical studies revealed that Ca(2+)-free CaM and Hsc70 bind AtBAG5 independently, whereas Ca(2+)-saturated CaM and Hsc70 bind AtBAG5 with negative cooperativity.

2. Data conclude that an HSC70-SGT1 chaperone complex is important for multiple plant environmental responses and that the evolutionarily conserved SGS domain of SGT1 is a key determinant of the HSC70-SGT1 association.

3. HSC70-1 is involved in development and abiotic stress responses in Arabidopsis.

4. These data suggest that both HSC70-1 and the WPP-domain proteins play a role in facilitating WIT1 nuclear envelope targeting; this may be the first described in planta activity for the WPP-domain proteins.

Mouse (Murine) Heat Shock 70kDa Protein 1B (HSPA1B) interaction partners

1. the presence of tumor-derived memebrane bound Hsp70 in tunneling nanotubes with a diameter ranging from 120 to 140 nm predominantly originates from cholesterol-rich-microdomains containing the lipid compound globoyltriaosylceramide, is reported.

2. binding of IL-5 to IL-5Ralpha receptors enhances angiogenic responses by stimulating the expression of HSP70-1 via the eNOS signaling pathway.

3. The present study clearly demonstrated that the ectromelia virus infection upregulates the expression of Hspa1b in order to promote its replication.

4. Downregulation of miR-199b-5p induced differentiation of Bone-marrow mesenchymal stem cells toward cardiomyocyte-like cells partly via the HSF1/HSP70 signaling pathway.

5. HSP70 expression is up-regulated in fatty liver.

6. CM-695, a small molecule that induces the expression of the HSPA1A/B genes, increases the vessel wall levels of Hsp70 and prevents thrombosis at least as efficiently as rivaroxaban without increasing bleeding risk.

7. mHSP70407-426 could assist VEGF to display enhanced anti-tumor effects, which are important for the further application of mHSP70407-426 to enhance antigen-specific immune responses

8. Extracellular Hsp70 and Hsp90, either in soluble form or secreted as part of exosomes from tumor cells, are responsible for tumor induction of cachexia.

9. HSP70 functions as a negative regulator in the TGF-beta- stimulated VEGF synthesis in osteoblasts, and that the suppressive effect of HSP70 is exerted via regulation of p38 MAP kinase.

10. The data implicate an involvement of Hsp70 oxidatively damaged protein degradation by the 20S proteasome.

11. interaction between BAG3 and HSP70 is essential for BAG3 to stabilize small heat shock proteins and maintain cardiomyocyte protein homeostasis

12. Data show that Klotho protein is present in the heart, and reduced levels of myocardial Klotho in aging mice is accompanied by lower levels heat shock protein 70 (HSP70) in the myocardium.

13. analysis of the intracellular pathways implicated in Hsp70 regulated signal transduction showed the involvement of both PI3K/AKT and NF-kappaB.

14. HSPA1A/B induction is a novel approach to delay thrombus formation with minimal bleeding risk in knockout mice

15. Hsp70 expression was observed trophoblast cells and decidual cells and was relatively constant throughout the pregnancy.

16. The results of comparative analysis of interaction between the protein cytotoxic complex Tag 7-Hsp70 and the Tag 7 component of this complex with TNFR1 receptor in solution and in tumor cells are presented.

17. the protective effect of HSP70 may be associated with inhibition of NF-kappaB and stimulation of NOS/NO signaling pathways

18. activation of the HSP70-TLR4 axis, stimulated at least in part by albumin, in the tubular cell is a newly identified mechanism associated with induction of tubulointerstitial inflammation.

19. Studied the protein expression of BCL2, FGF-R1, and HSP70 after short-time magnetic thermoablative tumor treatment using immunohistochemistry in a human BT474 breast cancer mouse xenograft model.

20. Knockdown lines were created for specific DSBs in regions of the chromosome that are coding for HSPA1B. Clonogenic cell survival was significantly lower in irradiated Hsp70 KD cells with low mHsp70 expression, than in ctrl cells.

Pig (Porcine) Heat Shock 70kDa Protein 1B (HSPA1B) interaction partners

1. overexpression of the HSP70.2 gene in multiple organs of transgenic mice improves survival during heatstroke by reducing hyperthermia, circulatory shock, and cerebral ischemia and damage

Cow (Bovine) Heat Shock 70kDa Protein 1B (HSPA1B) interaction partners

1. hsp70 gene is a promising candidate gene to be validated in independent cattle populations and functional studies related to cold stress resilience in cattle.

2. In vitro acute heat stress and Geranylgeranylacetone induction increased the level of Hsp70 which upregulated the expression of TLR2/4 and NOD1/2 in both the cell cultured models. However, the expression level of TLR4 was found to be highest followed by NOD2, TLR2 and NOD1.

3. protects glutamatergic synaptic transmission in olfactory cortex cells, against acute anoxia

4. A new SNP in the 3'-UTR of the hsp 70-1 gene in Bos taurus and Bos indicus

5. The purified 44-kD ATPase domain from HSP70 exhibited intrinsic ATP-ADP exchange activity and acid-stable autophosphorylation at Thr204.

6. The effect of culture conditions on expression of heat shock protein 70 and Bax protein in bovine blastocysts is reported.

7. that HSC70 preconditioning (1) attenuates the TNF-alpha response to endotoxin in macrophages in vitro, (2) induces cardiac functional tolerance to endotoxin and (3) reduces NF-kappaB activity, and TNF-alpha and ICAM-1 levels in heart tissue.

8. the presence of SNPs (C/- and G/T) in the 5'-UTR region of inducible Hsp70.1 ameliorates HS response and tolerance to heat of bovine peripheral blood mononuclear cells

9. This study showed that Hsp70 concentration is a reliable indicator of chronic stress but is not a reliable indicator of a single stressor when animals are exposed to multiple chronic stressors.

10. Five novel SNPs located in the 3' flanking region of the inducible bovine HSP70A1A gene were identified in a Chinese Holstein population.

11. Heat shock increased both HSP70 and IFNT expression in blastocysts.

12. the promoter region of bovine hsp70.1 gene is polymorphic and may be useful in selection of dairy cows for relatively better thermotolerance and higher milk production.

13. More DNMT1 mRNA was detected in the transgenic somatic cell nuclear transfer (SCNT) group than the other three groups. Hsp 70.1 mRNA was detected in the in vitro fertilzation embryos. Mash2 mRNA was present at highest levels in transgenic SCNT embryos.

14. In Sahiwal cattle the mRNA expression of HSP70 and its protein concentration were higher (P<0.05) during peak summer (44 degrees C) and winter (10 degrees C) as compared to Frieswal cattle. This investigation supports the earlier information on the higher adaptability of indigenous cattle breeds to hot and humid conditions compared to the crossbreds of temperate cattle breeds.

15. Inhibition of Hsp70 by using the Hsp70 inhibitor KNK437 or knock down Hsp70 using siRNA exaggerated and overexpression of Hsp70 prevented the second phase disruption of lung endothelial integrity.

16. Prostaglandin E synthase interacts with inducible heat shock protein 70 after heat stress in bovine primary dermal fibroblast cells.

17. Hsp70-1A is a biomarker of low beef tenderness across the cattle breeds. [HSP70-1a]

18. It is suggested that 9 SNPs increase the susceptibility to mastitis due to their low polymorphisms and can be used as molecular markers to breed the dairy cows resistant to mastitis.