anti-Heat Shock Protein 70 (HSP70) Antibodies

heat shock protein\; may have an important role following forebrain ischemia and may allow astrocytes to protect neurons [RGD, Feb 2006].. Additionally we are shipping HSP70 Kits (88) and HSP70 Proteins (33) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
Anti-Human HSP70 HSP70 3308 P34932
Anti-Mouse HSP70 HSP70 15511 P17879
Anti-Rat HSP70 HSP70 266759 O88600
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Top anti-HSP70 Antibodies at antibodies-online.com

Showing 10 out of 1024 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Caenorhabditis elegans Mouse Un-conjugated AA, BI, ELISA, FACS, ICC, IEM, IF, IHC, WB Hsp70 (C92) Mouse Melanoma. Hsp70 (C92), cell lines. 50 μg Log in to see 3 to 4 Days
€235.84
Details
Cow Rabbit Un-conjugated IHC, WB 100 μg Log in to see 2 to 3 Days
€247.79
Details
Cow Mouse Un-conjugated IHC (fro), IHC (p), WB   100 μg Log in to see 4 to 6 Days
€247.79
Details
Beluga Rabbit HRP ICC, IF, IP, IHC, ELISA, WB Immunocytochemistry/Immunofluorescence analysis using Rabbit Anti-Hsp70 Polyclonal Antibody . Tissue: Heat Shocked HeLa Cells. Species: Human. Fixation: 2% Formaldehyde for 20 min at RT. Primary Antibody: Rabbit Anti-Hsp70 Polyclonal Antibody  at 1:100 for 12 hours at 4°C. Secondary Antibody: FITC Goat Anti-Rabbit (green) at 1:200 for 2 hours at RT. Counterstain: DAPI (blue) nuclear stain at 1:40000 for 2 hours at RT. Localization: Cytoplasm. Magnification: 100x. (A) DAPI (blue) nuclear stain. (B) Anti-Hsp70 Antibody. (C) Composite. Heat Shocked at 42°C for 1h. Immunohistochemistry analysis using Rabbit Anti-HSP70 Polyclonal Antibody . Tissue: colon carcinoma. Species: Human. Fixation: Formalin. Primary Antibody: Rabbit Anti-HSP70 Polyclonal Antibody  at 1:50000 for 12 hours at 4°C. Secondary Antibody: Biotin Goat Anti-Rabbit at 1:2000 for 1 hour at RT. Counterstain: Methyl Green at 200uL for 2 min at RT. 100 μL Log in to see 3 to 4 Days
€438.32
Details
Beluga Rabbit FITC ICC, IF, IP, IHC, ELISA, WB Immunocytochemistry/Immunofluorescence analysis using Rabbit Anti-Hsp70 Polyclonal Antibody . Tissue: Heat Shocked HeLa Cells. Species: Human. Fixation: 2% Formaldehyde for 20 min at RT. Primary Antibody: Rabbit Anti-Hsp70 Polyclonal Antibody  at 1:100 for 12 hours at 4°C. Secondary Antibody: FITC Goat Anti-Rabbit (green) at 1:200 for 2 hours at RT. Counterstain: DAPI (blue) nuclear stain at 1:40000 for 2 hours at RT. Localization: Cytoplasm. Magnification: 100x. (A) DAPI (blue) nuclear stain. (B) Anti-Hsp70 Antibody. (C) Composite. Heat Shocked at 42°C for 1h. Immunohistochemistry analysis using Rabbit Anti-HSP70 Polyclonal Antibody . Tissue: colon carcinoma. Species: Human. Fixation: Formalin. Primary Antibody: Rabbit Anti-HSP70 Polyclonal Antibody  at 1:50000 for 12 hours at 4°C. Secondary Antibody: Biotin Goat Anti-Rabbit at 1:2000 for 1 hour at RT. Counterstain: Methyl Green at 200uL for 2 min at RT. 100 μL Log in to see 3 to 4 Days
€442.92
Details
Beluga Rabbit Alkaline Phosphatase (AP) ICC, IF, IP, IHC, ELISA, WB Immunocytochemistry/Immunofluorescence analysis using Rabbit Anti-Hsp70 Polyclonal Antibody . Tissue: Heat Shocked HeLa Cells. Species: Human. Fixation: 2% Formaldehyde for 20 min at RT. Primary Antibody: Rabbit Anti-Hsp70 Polyclonal Antibody  at 1:100 for 12 hours at 4°C. Secondary Antibody: FITC Goat Anti-Rabbit (green) at 1:200 for 2 hours at RT. Counterstain: DAPI (blue) nuclear stain at 1:40000 for 2 hours at RT. Localization: Cytoplasm. Magnification: 100x. (A) DAPI (blue) nuclear stain. (B) Anti-Hsp70 Antibody. (C) Composite. Heat Shocked at 42°C for 1h. Immunohistochemistry analysis using Rabbit Anti-HSP70 Polyclonal Antibody . Tissue: colon carcinoma. Species: Human. Fixation: Formalin. Primary Antibody: Rabbit Anti-HSP70 Polyclonal Antibody  at 1:50000 for 12 hours at 4°C. Secondary Antibody: Biotin Goat Anti-Rabbit at 1:2000 for 1 hour at RT. Counterstain: Methyl Green at 200uL for 2 min at RT. 100 μL Log in to see 3 to 4 Days
€445.22
Details
Beluga Rabbit Biotin ICC, IF, IP, IHC, ELISA, WB Immunocytochemistry/Immunofluorescence analysis using Rabbit Anti-Hsp70 Polyclonal Antibody . Tissue: Heat Shocked HeLa Cells. Species: Human. Fixation: 2% Formaldehyde for 20 min at RT. Primary Antibody: Rabbit Anti-Hsp70 Polyclonal Antibody  at 1:100 for 12 hours at 4°C. Secondary Antibody: FITC Goat Anti-Rabbit (green) at 1:200 for 2 hours at RT. Counterstain: DAPI (blue) nuclear stain at 1:40000 for 2 hours at RT. Localization: Cytoplasm. Magnification: 100x. (A) DAPI (blue) nuclear stain. (B) Anti-Hsp70 Antibody. (C) Composite. Heat Shocked at 42°C for 1h. Immunohistochemistry analysis using Rabbit Anti-HSP70 Polyclonal Antibody . Tissue: colon carcinoma. Species: Human. Fixation: Formalin. Primary Antibody: Rabbit Anti-HSP70 Polyclonal Antibody  at 1:50000 for 12 hours at 4°C. Secondary Antibody: Biotin Goat Anti-Rabbit at 1:2000 for 1 hour at RT. Counterstain: Methyl Green at 200uL for 2 min at RT. 100 μL Log in to see 3 to 4 Days
€447.52
Details
Beluga Rabbit PE ICC, IF, IP, IHC, ELISA, WB Immunocytochemistry/Immunofluorescence analysis using Rabbit Anti-Hsp70 Polyclonal Antibody . Tissue: Heat Shocked HeLa Cells. Species: Human. Fixation: 2% Formaldehyde for 20 min at RT. Primary Antibody: Rabbit Anti-Hsp70 Polyclonal Antibody  at 1:100 for 12 hours at 4°C. Secondary Antibody: FITC Goat Anti-Rabbit (green) at 1:200 for 2 hours at RT. Counterstain: DAPI (blue) nuclear stain at 1:40000 for 2 hours at RT. Localization: Cytoplasm. Magnification: 100x. (A) DAPI (blue) nuclear stain. (B) Anti-Hsp70 Antibody. (C) Composite. Heat Shocked at 42°C for 1h. Immunohistochemistry analysis using Rabbit Anti-HSP70 Polyclonal Antibody . Tissue: colon carcinoma. Species: Human. Fixation: Formalin. Primary Antibody: Rabbit Anti-HSP70 Polyclonal Antibody  at 1:50000 for 12 hours at 4°C. Secondary Antibody: Biotin Goat Anti-Rabbit at 1:2000 for 1 hour at RT. Counterstain: Methyl Green at 200uL for 2 min at RT. 100 μL Log in to see 3 to 4 Days
€448.67
Details
Beluga Rabbit Streptavidin ICC, IF, IP, IHC, ELISA, WB Immunocytochemistry/Immunofluorescence analysis using Rabbit Anti-Hsp70 Polyclonal Antibody . Tissue: Heat Shocked HeLa Cells. Species: Human. Fixation: 2% Formaldehyde for 20 min at RT. Primary Antibody: Rabbit Anti-Hsp70 Polyclonal Antibody  at 1:100 for 12 hours at 4°C. Secondary Antibody: FITC Goat Anti-Rabbit (green) at 1:200 for 2 hours at RT. Counterstain: DAPI (blue) nuclear stain at 1:40000 for 2 hours at RT. Localization: Cytoplasm. Magnification: 100x. (A) DAPI (blue) nuclear stain. (B) Anti-Hsp70 Antibody. (C) Composite. Heat Shocked at 42°C for 1h. Immunohistochemistry analysis using Rabbit Anti-HSP70 Polyclonal Antibody . Tissue: colon carcinoma. Species: Human. Fixation: Formalin. Primary Antibody: Rabbit Anti-HSP70 Polyclonal Antibody  at 1:50000 for 12 hours at 4°C. Secondary Antibody: Biotin Goat Anti-Rabbit at 1:2000 for 1 hour at RT. Counterstain: Methyl Green at 200uL for 2 min at RT. 100 μL Log in to see 3 to 4 Days
€449.82
Details
Beluga Rabbit PerCP ICC, IF, IP, IHC, ELISA, WB Immunocytochemistry/Immunofluorescence analysis using Rabbit Anti-Hsp70 Polyclonal Antibody . Tissue: Heat Shocked HeLa Cells. Species: Human. Fixation: 2% Formaldehyde for 20 min at RT. Primary Antibody: Rabbit Anti-Hsp70 Polyclonal Antibody  at 1:100 for 12 hours at 4°C. Secondary Antibody: FITC Goat Anti-Rabbit (green) at 1:200 for 2 hours at RT. Counterstain: DAPI (blue) nuclear stain at 1:40000 for 2 hours at RT. Localization: Cytoplasm. Magnification: 100x. (A) DAPI (blue) nuclear stain. (B) Anti-Hsp70 Antibody. (C) Composite. Heat Shocked at 42°C for 1h. Immunohistochemistry analysis using Rabbit Anti-HSP70 Polyclonal Antibody . Tissue: colon carcinoma. Species: Human. Fixation: Formalin. Primary Antibody: Rabbit Anti-HSP70 Polyclonal Antibody  at 1:50000 for 12 hours at 4°C. Secondary Antibody: Biotin Goat Anti-Rabbit at 1:2000 for 1 hour at RT. Counterstain: Methyl Green at 200uL for 2 min at RT. 100 μL Log in to see 3 to 4 Days
€450.97
Details

Top referenced anti-HSP70 Antibodies

  1. Caenorhabditis elegans (C. elegans) Monoclonal HSP70 Primary Antibody for AA, BI - ABIN361707 : Boorstein, Ziegelhoffer, Craig: Molecular evolution of the HSP70 multigene family. in Journal of molecular evolution 1994 (PubMed)
    Show all 44 Pubmed References

  2. Cow (Bovine) Monoclonal HSP70 Primary Antibody for IHC (fro), IHC (p) - ABIN3043650 : Fan, Jiang, Yang, Liu, Song, Pan: Effects of adrenergic agents on stress-induced brain microstructural and immunochemical changes in adult male Wistar rats. in Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft 2011 (PubMed)
    Show all 7 Pubmed References

  3. Algae (Desmodesmus subspicatus) Polyclonal HSP70 Primary Antibody for IP, WB - ABIN2487328 : Muralidharan, Oksman, Pal, Lindquist, Goldberg: Plasmodium falciparum heat shock protein 110 stabilizes the asparagine repeat-rich parasite proteome during malarial fevers. in Nature communications 2012 (PubMed)
    Show all 7 Pubmed References

  4. Rat (Rattus) Polyclonal HSP70 Primary Antibody for ELISA, WB - ABIN1574053 : Pons, Ferrebuz, Quiroz, Romero-Vasquez, Parra, Johnson, Rodriguez-Iturbe: Immune reactivity to heat shock protein 70 expressed in the kidney is cause of salt-sensitive hypertension. in American journal of physiology. Renal physiology 2013 (PubMed)
    Show all 3 Pubmed References

  5. Plasmodium falciparum Polyclonal HSP70 Primary Antibody for ICC, IF - ABIN361730 : Bork, Sander, Valencia: An ATPase domain common to prokaryotic cell cycle proteins, sugar kinases, actin, and hsp70 heat shock proteins. in Proceedings of the National Academy of Sciences of the United States of America 1992 (PubMed)
    Show all 10 Pubmed References

  6. Human Polyclonal HSP70 Primary Antibody for ELISA, WB - ABIN543936 : Broquet, Thomas, Masliah, Trugnan, Bachelet: Expression of the molecular chaperone Hsp70 in detergent-resistant microdomains correlates with its membrane delivery and release. in The Journal of biological chemistry 2003 (PubMed)
    Show all 3 Pubmed References

  7. Human Polyclonal HSP70 Primary Antibody for IF (p), IHC (p) - ABIN725360 : Wang, Wang, Feng, Mi, Chen, Shang, Chen: Comparative vesicle proteomics reveals selective regulation of protein expression in chestnut blight fungus by a hypovirus. in Journal of proteomics 2012 (PubMed)
    Show all 3 Pubmed References

  8. Fish Polyclonal HSP70 Primary Antibody for WB - ABIN361870 : Brown, Hong-Brown, Doxsey, Welch: Molecular chaperones and the centrosome. A role for HSP 73 in centrosomal repair following heat shock treatment. in The Journal of biological chemistry 1996 (PubMed)
    Show all 8 Pubmed References

  9. Human Polyclonal HSP70 Primary Antibody for FACS, IF - ABIN388133 : Strausberg, Feingold, Grouse, Derge, Klausner, Collins, Wagner, Shenmen, Schuler, Altschul, Zeeberg, Buetow, Schaefer, Bhat, Hopkins, Jordan, Moore, Max, Wang, Hsieh, Diatchenko, Marusina, Farmer et al.: Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ... in Proceedings of the National Academy of Sciences of the United States of America 2002 (PubMed)
    Show all 6 Pubmed References

  10. Human Monoclonal HSP70 Primary Antibody for IF, IHC - ABIN966316 : Pang: Hospital-based dermatology: my personal journey. in Singapore medical journal 2009 (PubMed)
    Show all 2 Pubmed References

More Antibodies against HSP70 Interaction Partners

Human Heat Shock Protein 70 (HSP70) interaction partners

  1. These results confirmed pro-inflammatory function of extracellular Hsp70.

  2. Serum HSP70 is a biomarker for early diagnosis of lung cancer.

  3. The dimerization of GRPEL2 may activate the folding machinery responsible for protein import into mitochondrial matrix or enhance the chaperone activity of mitochondrial HSP70, thus protecting mitochondrial proteostasis in oxidative stress.

  4. ARD1-mediated Hsp70 acetylation is a regulatory mechanism that temporally balances protein refolding/degradation in response to stress

  5. this study provided a mechanistic understanding of the dynamic nature of the polypeptide-binding pocket in the Hsp70 chaperone cycle.

  6. Hsp70 protected human trabecular meshwork cells injury induced by UVB through Smad pathway; Hsp70 promoted cell proliferation and suppressed apoptosis.

  7. Hsc70 and DNAJC14 are required for the unconventional trafficking of H723R-pendrin.

  8. Laryngopharyngeal reflux may play a role in the development of chronic rhinosinusitis (CRS) through pepsin A reflux, and increased HSP70 expression may be associated with the pathogenic mechanism of mucosal injury in CRS.

  9. Nuclear HSP70 leads to enhancement of vaccinia H1-related phosphatase (VHR) activity via protein-protein interaction rather than its molecular chaperone activity, thereby suppressing excessive ERK activation. Downregulation of either VRK3 or HSP70 rendered cells vulnerable to glutamate-induced apoptosis.

  10. downregulation of Hsp70 and HspBP1 represents a unique feature of patients with preterm prelabor rupture of membranes

  11. we sought to investigate mechanisms mediated by Hsp70 acetylation in relation to apoptotic and autophagic programmed cell death. Upon stress-induced apoptosis, Hsp70 acetylation inhibits apoptotic cell death, mediated by Hsp70 association with apoptotic protease-activating factor (Apaf)-1 and apoptosis-inducing factor (AIF), key modulators of caspase-dependent and -independent apoptotic pathways, respectively

  12. This review article documents reduced levels of mature miR-23a in various tumors, primarily due to epigenetic silencing or alterations in biogenesis pathways. Moreover, inhibition of miR-23a in stressed cells represent a general mechanism for inducing apoptosis and these microRNAs are showed to be regulated by molecular chaperon HSP70

  13. High Hsp70 and Hsp90 expression was associated with worse overall survival and disease-free survival [review and meta-analysis]

  14. The level of Hsp70 was higher in the allergic rhinitis (AR) group compared with the non-AR group. Furthermore, treatment of HNE cells with Th2 cytokines induced secretion of Hsp70 into the extracellular area, and did not influence the production of Hsp70. These results suggest that Hsp70 may play a major role in the pathogenesis of AR.

  15. The article results indicate that the heat-shock protein HSP70-2 (+1538 A/G) and HSP70-hom (+2437 C/T) SNPs are highly associated with renal complications in Type 2 Diabetes Mellitus among the South Indian population.

  16. HSP70-Hrd1 axis represents a potential therapeutic target for restoring the oncorepressor activity of unstable lymphoma-associated Blimp-1 mutants.

  17. verified the interaction of cellular chaperon HSP70 with Porcine reproductive and respiratory syndrome virus NSP12, and demonstrated that NSP12 could recruit HSP70 to maintain its own stability and benefit for the virus replication

  18. Modulatory action of extracellular HSP70 on A549 inflammatory response through RAGE was able to evoke important expression changes in monocyte, showing its relevance in influencing the interaction between cancer and immune system cell.

  19. Here the authors show that in budding yeast, Hsf1 basally associates with the chaperone Hsp70 and this association is transiently disrupted by heat shock, providing the first evidence that a chaperone repressor directly regulates Hsf1 activity.

  20. Pharmacological or genetic activation of heat shock protein 70 (Hsp70) protects against loss of parkin Function. Heat shock protein members may act as compensatory factors for parkin loss of function and that the exploitation of these factors may be of potential therapeutic value.

Tomato (Solanum lycopersicum) Heat Shock Protein 70 (HSP70) interaction partners

  1. Experimental evidence show: apoptozole forms aggregates under aqueous conditions that could interact with HSP70 proteins in a non-specific manner.

  2. Disrupts the Hsp70-Bag3 interaction.

  3. Increased Hsp70 expression levels are associated with squamous cell carcinoma of the head and neck.

  4. Hsp70 and Hsp90 chaperones coregulate heat shock gene expression within a network of mutual, but factor-specific, interactions with heat stress transcription factors.

  5. salicylic acid-mediated potentiation of Hsp70 is due to modulation of heat shock factors by salicylic acid.

Pig (Porcine) Heat Shock Protein 70 (HSP70) interaction partners

  1. HSP70 indirectly interacted with Smad3.

  2. There was a significant decrease in the systemic HSP70 levels of trauma groups (moderate and severe hemorrhage) when compared to the sham trauma group, which was significantly decreased compared to baseline values in severe hemorrhage over the entire time course.

  3. Host HSP70 and Classical swine fever virus NS5A protein complex formation is confirmed by coimmunoprecipitation and GST-pulldown studies.

  4. This study evaluated the expression of 70kDa heat shock proteins and the concentration of thiobarbituric acid reactive substances and nitric oxide ions as markers of oxidative stress in swine.

  5. This study revealed that HSP70 is an essential host factor required for the replication of porcine reproductive and respiratory syndrome virus.

  6. A specific interaction between Hsp70 and porcine circovirus type 2 Cap (capsid protein) was confirmed by colocalization by confocal microscopy and co-immunoprecipitation.

  7. This work investigated the expression of heat shock protein 70 by Western blot in swine liver. Animals in an intensive/indoor confinement system showed significantly higher HSP70 values compared with those in an extensive/outdoor system.

  8. The results indicate that Heat shock protein 70 (Hsp70) mediates distinct stress-related functions in different tissues during transportation. Heat shock factor-1 (HSF-1) levels were reduced at 1 and 4 h only in the hearts of transported pigs.

  9. These results indicated that the expression of Hsp70 in the intestinal piglets was upregulated by IUGR, and different intestinal sites had different responses to stress.

  10. Induction of tolerance to heat shock correlated with the induced expression of heat shock protein 70. HSP70 and compatible osmolytes have distinct roles in cellular adaptation to these stresses.

  11. a parameter of early mRNA expression during intestinal ischemia reperfusion injury

  12. HSP-70 is an endogenous protectant of which its actions may be unmasked and/or potentiated with exogenous administration before brain injury

  13. Data demonstrate that lipopolysaccharides evoke a heat shock response, with an increase heat shock proteins 70 and Hsp32) and of VEGF, a specific endothelial cell growth factor.

  14. Extremely low frequency magnetic field exposure induced an increase in the mRNA levels which was statistically significant for Hsp70.

Arabidopsis thaliana Heat Shock Protein 70 (HSP70) interaction partners

  1. ability of multiple unrelated Hsp70-binding elements to support protein import verified that the majority of TPs utilize an N-terminal Hsp70-binding domain during translocation and expand the mechanistic view of the import process

  2. temperature regulated expression of AtHSP70-4 may be mediated by cell cycle transcription factors and participate in plant acclimations to non-stress temperature changes

  3. This work describes a detailed quantitative interaction study between the novel plastidial chaperone receptor OEP61 and isoforms of the chaperone types Hsp70 and Hsp90 using the optical method of total internal reflection ellipsometry.

  4. Chloroplasts have two chaperone systems facilitating protein translocation into the stroma: the cpHsc70 system and the Hsp93/Tic40 system.

  5. A working hypothesis is that Hsp70 has a defense-promoting activity(s) that HopI1 or high temperature can subvert.

  6. Hsc70-4 and CHIP were highly induced in ppi2 mutant plants, where they mediated the degradation of chloroplast-targeted precursors through the ubiquitin-26S proteasome system.

  7. The MAPK-EGR-1-HSP70 pathway regulates the cigarette smoke-induced inflammatory process.

Mouse (Murine) Heat Shock Protein 70 (HSP70) interaction partners

  1. binding of IL-5 to IL-5Ralpha receptors enhances angiogenic responses by stimulating the expression of HSP70-1 via the eNOS signaling pathway.

  2. The present study clearly demonstrated that the ectromelia virus infection upregulates the expression of Hspa1b in order to promote its replication.

  3. Downregulation of miR-199b-5p induced differentiation of Bone-marrow mesenchymal stem cells toward cardiomyocyte-like cells partly via the HSF1/HSP70 signaling pathway.

  4. HSP70 expression is up-regulated in fatty liver.

  5. CM-695, a small molecule that induces the expression of the HSPA1A/B genes, increases the vessel wall levels of Hsp70 and prevents thrombosis at least as efficiently as rivaroxaban without increasing bleeding risk.

  6. mHSP70407-426 could assist VEGF to display enhanced anti-tumor effects, which are important for the further application of mHSP70407-426 to enhance antigen-specific immune responses

  7. Extracellular Hsp70 and Hsp90, either in soluble form or secreted as part of exosomes from tumor cells, are responsible for tumor induction of cachexia.

  8. HSP70 functions as a negative regulator in the TGF-beta- stimulated VEGF synthesis in osteoblasts, and that the suppressive effect of HSP70 is exerted via regulation of p38 MAP kinase.

  9. The data implicate an involvement of Hsp70 oxidatively damaged protein degradation by the 20S proteasome.

  10. interaction between BAG3 and HSP70 is essential for BAG3 to stabilize small heat shock proteins and maintain cardiomyocyte protein homeostasis

  11. Data show that Klotho protein is present in the heart, and reduced levels of myocardial Klotho in aging mice is accompanied by lower levels heat shock protein 70 (HSP70) in the myocardium.

  12. analysis of the intracellular pathways implicated in Hsp70 regulated signal transduction showed the involvement of both PI3K/AKT and NF-kappaB.

  13. HSPA1A/B induction is a novel approach to delay thrombus formation with minimal bleeding risk in knockout mice

  14. Hsp70 expression was observed trophoblast cells and decidual cells and was relatively constant throughout the pregnancy.

  15. The results of comparative analysis of interaction between the protein cytotoxic complex Tag 7-Hsp70 and the Tag 7 component of this complex with TNFR1 receptor in solution and in tumor cells are presented.

  16. the protective effect of HSP70 may be associated with inhibition of NF-kappaB and stimulation of NOS/NO signaling pathways

  17. activation of the HSP70-TLR4 axis, stimulated at least in part by albumin, in the tubular cell is a newly identified mechanism associated with induction of tubulointerstitial inflammation.

  18. Studied the protein expression of BCL2, FGF-R1, and HSP70 after short-time magnetic thermoablative tumor treatment using immunohistochemistry in a human BT474 breast cancer mouse xenograft model.

  19. Knockdown lines were created for specific DSBs in regions of the chromosome that are coding for HSPA1B. Clonogenic cell survival was significantly lower in irradiated Hsp70 KD cells with low mHsp70 expression, than in ctrl cells.

  20. Hsp70.1-deficient mice were more resistant to developing experimental autoimmune encephalomyelitis (EAE) compared with their wild-type littermates, suggesting Hsp70.1 plays a role in promoting myelin oligodendrocyte glycoprotein specific T cell response.

Cow (Bovine) Heat Shock Protein 70 (HSP70) interaction partners

  1. In vitro acute heat stress and Geranylgeranylacetone induction increased the level of Hsp70 which upregulated the expression of TLR2/4 and NOD1/2 in both the cell cultured models. However, the expression level of TLR4 was found to be highest followed by NOD2, TLR2 and NOD1.

  2. protects glutamatergic synaptic transmission in olfactory cortex cells, against acute anoxia

  3. A new SNP in the 3'-UTR of the hsp 70-1 gene in Bos taurus and Bos indicus

  4. The purified 44-kD ATPase domain from HSP70 exhibited intrinsic ATP-ADP exchange activity and acid-stable autophosphorylation at Thr204.

  5. The effect of culture conditions on expression of heat shock protein 70 and Bax protein in bovine blastocysts is reported.

  6. that HSC70 preconditioning (1) attenuates the TNF-alpha response to endotoxin in macrophages in vitro, (2) induces cardiac functional tolerance to endotoxin and (3) reduces NF-kappaB activity, and TNF-alpha and ICAM-1 levels in heart tissue.

  7. the presence of SNPs (C/- and G/T) in the 5'-UTR region of inducible Hsp70.1 ameliorates HS response and tolerance to heat of bovine peripheral blood mononuclear cells

  8. This study showed that Hsp70 concentration is a reliable indicator of chronic stress but is not a reliable indicator of a single stressor when animals are exposed to multiple chronic stressors.

  9. Five novel SNPs located in the 3' flanking region of the inducible bovine HSP70A1A gene were identified in a Chinese Holstein population.

  10. Heat shock increased both HSP70 and IFNT expression in blastocysts.

  11. the promoter region of bovine hsp70.1 gene is polymorphic and may be useful in selection of dairy cows for relatively better thermotolerance and higher milk production.

  12. More DNMT1 mRNA was detected in the transgenic somatic cell nuclear transfer (SCNT) group than the other three groups. Hsp 70.1 mRNA was detected in the in vitro fertilzation embryos. Mash2 mRNA was present at highest levels in transgenic SCNT embryos.

  13. In Sahiwal cattle the mRNA expression of HSP70 and its protein concentration were higher (P<0.05) during peak summer (44 degrees C) and winter (10 degrees C) as compared to Frieswal cattle. This investigation supports the earlier information on the higher adaptability of indigenous cattle breeds to hot and humid conditions compared to the crossbreds of temperate cattle breeds.

  14. Inhibition of Hsp70 by using the Hsp70 inhibitor KNK437 or knock down Hsp70 using siRNA exaggerated and overexpression of Hsp70 prevented the second phase disruption of lung endothelial integrity.

  15. Prostaglandin E synthase interacts with inducible heat shock protein 70 after heat stress in bovine primary dermal fibroblast cells.

  16. Hsp70-1A is a biomarker of low beef tenderness across the cattle breeds. [HSP70-1a]

  17. It is suggested that 9 SNPs increase the susceptibility to mastitis due to their low polymorphisms and can be used as molecular markers to breed the dairy cows resistant to mastitis.

HSP70 Antigen Profile

Protein Summary

heat shock protein\; may have an important role following forebrain ischemia and may allow astrocytes to protect neurons

Gene names and symbols associated with HSP70

  • heat shock protein family A (Hsp70) member 4 (HSPA4) antibody
  • CG5834 gene product from transcript CG5834-RA (Hsp70Bbb) antibody
  • heat shock protein 70 (HSP70) antibody
  • heat shock protein family A (Hsp70) member 6 (HSPA6) antibody
  • heat shock 70kDa protein 2 (HSPA2) antibody
  • heat shock 70 kD protein cognate (HSP70) antibody
  • Hsp70 family chaperone (HSP70) antibody
  • Heat shock protein 70 (PCC7424_2419) antibody
  • Heat shock protein 70 (Isop_1041) antibody
  • Heat shock protein 70, putative (CGB_C3390W) antibody
  • Heat shock protein 70 (Bacsa_1698) antibody
  • heat shock protein 70 (dnaK-B) antibody
  • heat shock protein 70 (LOC100305036) antibody
  • heat shock protein 1B (Hspa1b) antibody
  • heat shock protein family A member 4 (Hspa4) antibody
  • heat shock 70kDa protein 1A (HSPA1A) antibody
  • heat shock protein 1 (hsp1) antibody
  • Heat Shock Protein (hsp-70) antibody
  • heat shock cognate 70-kd protein (hsp70) antibody
  • APG-2 antibody
  • ARABIDOPSIS HEAT SHOCK PROTEIN 70 antibody
  • ATHSP70 antibody
  • CG5834 antibody
  • CG31354 antibody
  • DmelCG5834 antibody
  • heat shock protein 70 antibody
  • HS24/P52 antibody
  • hsc70 antibody
  • hsp68 antibody
  • Hsp70 antibody
  • Hsp70-1 antibody
  • HSP70-2 antibody
  • hsp70-5 antibody
  • Hsp70.1 antibody
  • hsp70B antibody
  • HSP70B' antibody
  • Hsp70Bb antibody
  • hsp70Bb-prime antibody
  • hsp70RY antibody
  • Hsp110 antibody
  • HSPA1 antibody
  • HSPA1B antibody
  • HSPA2 antibody
  • HSPA6 antibody
  • HSPH2 antibody
  • irp94 antibody
  • LOC100305036 antibody
  • RY antibody

Protein level used designations for HSP70

heat shock 70 kDa protein 4 , heat shock 70-related protein APG-2 , heat shock 70kD protein 4 , heat shock protein, 110 kDa , hsp70 RY , Hsp70Bbb , CG5834-PA , Hsp70Bbb-PA , heat shock 70 kDa protein 1 , Heat shock 70 kDa protein 6 , heat shock 70 kDa protein , heat shock 70 kDa protein B' , dnaK-type molecular chaperone , heat shock protein 70 , heat shock 70 kD protein cognate , hypothetical protein , Heat shock protein 70 , CF Hsp70 , Heat shock cognate 71 kDa protein , 68 kDa heat shock protein , heat shock 70 kDa protein 1B , heat shock 70kDa protein 1B , heat shock protein 70.1 , heat shock protein, 70 kDa 1 , ischemia responsive 94 kDa protein , 70 kda heat shock protein-2 , HSP70.2 , chaperone , heat shock 70 kD protein 2 , heat shock 70 kDa protein 2 , heat-shock 70-kilodalton protein 1B , CL45_1 , CL45_1(648) , CL45_1_ov , Heat shock 70 kDa protein , heat shock protein 70 kDa , hsp 70-1 , npi119-hsp1 , heat shock 70 kDa protein 1A/1B , Heat shock cognate 70 kDa protein , heat shock cognate 70-kd protein

GENE ID SPECIES
3308 Homo sapiens
50022 Drosophila melanogaster
403612 Canis lupus familiaris
100134914 Solanum lycopersicum
396906 Sus scrofa
423504 Gallus gallus
692373 Bombyx mori
820438 Arabidopsis thaliana
3636229 Candida albicans SC5314
7095334 Grapevine leafroll-associated virus 10
7110730 Cyanothece sp. PCC 7424
10155152 Isosphaera pallida ATCC 43644
10187290 Cryptococcus gattii WM276
10259602 Bacteroides salanitronis DSM 18170
10889164 Simkania negevensis Z
100305036 Ictalurus punctatus
15511 Mus musculus
266759 Rattus norvegicus
282254 Bos taurus
542423 Zea mays
100913152 Ovis aries
172757 Caenorhabditis elegans
100301691 Oncorhynchus mykiss
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