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may be involved in osteoblast recruitment into growing bone tissue. Additionally we are shipping and and many more products for this protein.
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HOXB4 (show HOXB4 ELISA Kits) binds to the Hemgn promoter region ex vivo & in vivo. Overexpressed Hemgn in bone marrow cells promoted cellular expansion in liquid cultures & increased self-renewal of myeloid colony-forming units.
Alternative promoters and polyadenylation regulate tissue-specific expression of Hemogen isoforms during hematopoiesis and spermatogenesis
EDAG is a key transcriptional regulator in maintaining the homeostasis of hematopoietic lineage commitment
Using ex vivo culture and HSC (show FUT1 ELISA Kits) transplantation models, study finds that EDAG enhances proliferative potential of human cord blood CD34 (show CD34 ELISA Kits)+ cells, increases survival, prevents cell apoptosis and promotes their repopulating capacity. EDAG overexpression induces rapid entry of CD34 (show CD34 ELISA Kits)+ cells into the cell cycle. Gene expression profile analysis shows that EDAG knockdown leads to down-regulation of positive cell cycle regulators.
a 7-gene signature was identified which correctly predicted the primary prefibrotic myelofibrosis group with a sensitivity of 100% and a specificity of 89%. The 7 genes included MPO (show MPO ELISA Kits), CEACAM8, CRISP3 (show CRISP3 ELISA Kits), MS4A3 (show MS4A3 ELISA Kits), CEACAM6, HEMGN, and MMP8 (show MMP8 ELISA Kits)
EDAG-1 regulates the proliferation and apoptosis of thyroid carcinoma via the PI3K (show PIK3CA ELISA Kits)/Akt (show AKT1 ELISA Kits) signaling pathway.
EDAG forms complex with GATA1 (show GATA1 ELISA Kits) and p300 (show EP300 ELISA Kits) and increases GATA1 (show GATA1 ELISA Kits) acetylation and transcriptional activity by facilitating the interaction between GATA1 (show GATA1 ELISA Kits) and p300 (show EP300 ELISA Kits)
EDAG enhances the protein stability of NPM1 (show NPM1 ELISA Kits) via binding to NPM1 (show NPM1 ELISA Kits), which plays a critical role in the anti-apoptosis of leukaemia cells.
EDAG functions as a positive regulator of erythroid/megakaryocytic differentiation in 32D cells associated with the induction of GATA-1 (show GATA1 ELISA Kits) and its target genes
results suggest a novel function of nuclear negative differentiation regulator (NDR (show STK38 ELISA Kits)) protein in regulating hematopoietic cell development [NDR (show STK38 ELISA Kits)]
These results suggest that EDAG regulates the proliferation and differentiation of hematopoietic cells and resists cell apoptosis through the activation of NF-kappa B (show NFKB1 ELISA Kits).
Hemgn promoter contains critical regulatory elements for its transcription in hematopoietic tissues and Hemgn is a direct target of GATA1 (show GATA1 ELISA Kits) in leukemia cells
The stable transfected cells were identified with RT-PCR and the effect of EDAG/siRNA on the growth of the human erythroleukemia cell line HEL was analyzed.
may be involved in osteoblast recruitment into growing bone tissue
, hemopoietic gene protein
, negative differentiation regulator protein
, nuclear protein
, erythroid differentiation gene 1
, erythroid differentiation-associated gene protein