anti-Heterogeneous Nuclear Ribonucleoprotein A2/B1 (HNRNPA2B1) Antibodies

HNRNPA2B1 belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). Additionally we are shipping HNRNPA2B1 Kits (51) and HNRNPA2B1 Proteins (10) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
HNRNPA2B1 3181 P22626
HNRNPA2B1 53379 O88569
HNRNPA2B1 362361 A7VJC2
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Top anti-HNRNPA2B1 Antibodies at antibodies-online.com

Showing 10 out of 131 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Dog Rabbit Un-conjugated IHC, WB WB Suggested Anti-HNRNPA2B1 Antibody Titration:  0.2-1 ug/ml  Positive Control:  Jurkat cell lysate HNRNPA2B1 is supported by BioGPS gene expression data to be expressed in Jurkat WB Suggested Anti-HNRNPA2B1  Antibody Titration: 0.2-1 µg/mL  Positive Control: Jurkat cell lysate  HNRNPA2B1 is supported by BioGPS gene expression data to be expressed in Jurkat 100 μL Log in to see 2 to 3 Days
$289.00
Details
Mouse Rabbit Un-conjugated IHC, WB Immunohistochemistry of paraffin-embedded human kidney using HNRNPA2B1 antibody at dilution of 1:200 (x400 lens). Immunohistochemistry of paraffin-embedded Rat brain using HNRNPA2B1 antibody at dilution of 1:100 (x400 lens). 100 μL Log in to see 13 to 14 Days
$523.93
Details
Chicken Mouse Un-conjugated ICC, IHC (fro), IF, IHC (p), IP, ELISA, WB Western blot for Anti-hnRNP-A2/B1 on HeLa cell extract 50 μL Log in to see 7 to 8 Days
$447.65
Details
Human Goat Un-conjugated ELISA, IHC, WB ABIN1781995 (0.3µg/ml) staining of MCF7 lysate (35µg protein in RIPA buffer). Detected by chemiluminescence. ABIN1781995 (0.01µg/ml) staining of NIH3T3 nuclear lysate (35µg protein in RIPA buffer). Detected by chemiluminescence. 100 μg Log in to see 6 to 7 Days
$429.84
Details
Chicken Mouse Un-conjugated ICC, IF, IP, WB Western Blot: hnRNP A2B1 Antibody (DP3B3) [ABIN267486] - hnRNP A2B1 expression in HeLa cells. Lane 1= 15 ug of HeLa nuclear extracts Lane 2= Co-IP of hnRNP A2B1. Image and data from confirmed customer review. Western Blot: hnRNP A2B1 Antibody (DP3B3) [ABIN267486] - Cell line lysates were separated on SDS-PAGE and probed with 2 ug/mL Monoclonal Anti-hnRNP-A2/B1 Clone: DP3B3. The antibody was developed using Goat Anti-Mouse IgG-Peroxidase and a chemiluminescent substrate. Lanes 1. HEK-293T 2. HeLa 3. G361 4. MDBK 5. MDCK 6. CHO 0.1 mL Log in to see 7 to 9 Days
$516.98
Details
Human Rabbit Un-conjugated IF/ICC, IHC, WB Western blot analysis of extracts of various cell lines, using HNRNPA2B1 antibody (ABIN5970508) at 1/1000 dilution. Immunohistochemistry of paraffin-embedded human colon using HNRNPA2B1 Antibody (ABIN5970508) at dilution of 1/200 (40x lens). 100 μL Log in to see 11 to 16 Days
$426.40
Details
Dog Rabbit Un-conjugated IC, IF, IHC, WB Immunofluorescent analysis of hnRNP A2/B1 staining in HeLa cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a hidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Immunohistochemical analysis of hnRNP A2/B1 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugad compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated ELISA, ICC, IF, IHC, WB Western blot analysis of extracts of hela , using HNRNPA2B1 antibody. The lane on the left is treated with the antigen-specific peptide. Western blot analysis of extracts of rat spleen cell lines, using HNRNPA2B1 antibody. 100 μL Log in to see 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated IF, IHC, WB Immunohistochemistry of paraffin-embedded human kidney using HNRNPA2B1 antibody at dilution of 1:200 (x400 lens). 100 μL Log in to see 11 to 13 Days
$366.77
Details
Human Rabbit Un-conjugated IF, ELISA, WB Western blot analysis of extracts from HepG2 cells, using hnRNP A2/B1 Antibody. The lane on the right is treated with the synthesized peptide. Immunofluorescence analysis of HeLa cells, using hnRNP A2/B1 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details

Top referenced anti-HNRNPA2B1 Antibodies

  1. Chicken Monoclonal HNRNPA2B1 Primary Antibody for ICC, IHC (fro) - ABIN108622 : Kamma, Horiguchi, Wan, Matsui, Fujiwara, Fujimoto, Yazawa, Dreyfuss: Molecular characterization of the hnRNP A2/B1 proteins: tissue-specific expression and novel isoforms. in Experimental cell research 1999 (PubMed)
    Show all 11 Pubmed References

  2. Chicken Monoclonal HNRNPA2B1 Primary Antibody for ICC, IHC (fro) - ABIN108621 : Maeto, Knott, Linero, Ellenberg, Scolaro, Castilla: Differential effect of acute and persistent Junin virus infections on the nucleo-cytoplasmic trafficking and expression of heterogeneous nuclear ribonucleoproteins type A and B. in The Journal of general virology 2011 (PubMed)
    Show all 11 Pubmed References

  3. Monoclonal HNRNPA2B1 Primary Antibody for IHC (fro), IF - ABIN534217 : Sato, Idogawa, Honda, Fujii, Kawashima, Takekuma, Hoshika, Hirohashi, Yamada: Beta-catenin interacts with the FUS proto-oncogene product and regulates pre-mRNA splicing. in Gastroenterology 2005 (PubMed)
    Show all 3 Pubmed References

  4. Chicken Monoclonal HNRNPA2B1 Primary Antibody for ICC, IF - ABIN267486 : Hou, Lersch, Gee, Ponthier, Lo, Wu, Turck, Koury, Krainer, Mayeda, Conboy: Decrease in hnRNP A/B expression during erythropoiesis mediates a pre-mRNA splicing switch. in The EMBO journal 2002 (PubMed)
    Show all 2 Pubmed References

  5. Human Monoclonal HNRNPA2B1 Primary Antibody for IF, ELISA - ABIN561313 : McDonald, Aulas, Destroismaisons, Pickles, Beleac, Camu, Rouleau, Vande Velde: TAR DNA-binding protein 43 (TDP-43) regulates stress granule dynamics via differential regulation of G3BP and TIA-1. in Human molecular genetics 2011 (PubMed)

  6. Human Polyclonal HNRNPA2B1 Primary Antibody for IHC, WB - ABIN6672566 : Wei, Dai, Zhou, He, Yao, Zhao, Guo, Yang: Oroxylin A activates PKM1/HNF4 alpha to induce hepatoma differentiation and block cancer progression. in Cell death & disease 2018 (PubMed)

More Antibodies against HNRNPA2B1 Interaction Partners

Human Heterogeneous Nuclear Ribonucleoprotein A2/B1 (HNRNPA2B1) interaction partners

  1. Study found that HNRNPA2B1 could be recruited to the 5'UTR of Sp1 mRNA regulating its expression as well as of hnRNPA2B1. Further data indicated that lung cancer patients with higher levels of Sp1 and Nm23-H1 also exhibited high levels of hnRNPA2/B1, suggesting a positive correlation between the levels of Sp1, Nm23-H1 and hnRNPA2B1 during lung cancer formation.

  2. Study demonstrated that dysfunctional mitochondria activate hnRNPA2 which in turn acetylates telomeric histones at H4K8. Using loss and gain-of-function studies also demonstrated that H4K8 acetylation is a signal for telomere shortening in response to mitochondrial stress.

  3. Arginine methylation reduces hnRNPA2 phase separation, disrupting arginine-mediated contacts. These results highlight the mechanistic role of specific LC domain interactions and modifications conserved across many hnRNP family members but altered by aggregation-causing pathological mutations.

  4. Moreover, SRSF10, hnRNP A1/A2 and Sam68 collaborate to drive the DNA damage-induced splicing response of several transcripts that produce components implicated in apoptosis, cell-cycle control and DNA repair.

  5. High HNRNPA2B1 expression is associated with cervical cancer.

  6. m6A switches may account for the previously seen enhanced hnRNP A2/B1 binding adjacent to m6A; instead of direct binding to m6A, m6A may promote accessibility of hnRNP A2/B1 to certain binding sites, thereby explaining how m6A can facilitate the ability of hnRNP A2/B1 to enhance nuclear events such as pri-miRNA processing

  7. revealed a novel heterozygous missense mutation of hnRNPA2B1 gene (c.929C>T, p. P310L) in the two patients which was then verified in all affected individuals

  8. Cilostazol pretreatment can reduce the excessive expression of inflammatory cytokines and chemokines and hnRNP A2/B1 by the Behcet's disease-related stimulants.

  9. UCP2 stimulates hnRNPA2/B1, GLUT1 and PKM2 expression and sensitizes pancreatic cancer cells to glycolysis inhibition.

  10. We demonstrate that the wild-type sequence harbors an hnRNP A1 and hnRNP A2/B1-binding exonic splicing silencer (ESS) overlapping the 5'splice site (5'ss) that prevents pseudoexon inclusion.we demonstrate that splice switching oligonucleotide (SSO) mediated blocking of the pseudoexon 3'ss and 5'ss effectively restores normal GLA splicing

  11. Data suggest that galectin-3 and heterogeneous ribonucleoprotein particle component hnRNPA2B1 interact as members of the early splicing machinery.

  12. effect of mutations on the aggregation propensity of hnRNPA2

  13. ALS-associated hnRNPA2B1 D290V mutant patient fibroblasts and motor neurons differentiated from iPSCs (iPSC-MNs) demonstrate abnormal splicing changes, likely due to increased nuclear-insoluble hnRNPA2B1. Mutant iPSC-MNs display decreased survival in long-term culture and exhibit hnRNPA2B1 localization to cytoplasmic granules as well as exacerbated changes in gene expression and splicing upon cellular stress.

  14. Motor-neuron disease (MND)-linked RNA-binding proteins (RBPs), TDP-43, FUS, and hnRNPA2B1, bind to and induce structural alteration of UGGAAexp. These RBPs suppress UGGAAexp-mediated toxicity in Drosophila by functioning as RNA chaperones for proper UGGAAexp folding and regulation of pentapeptide repeat translation.

  15. To examine the relationship between amino acid sequence and aggregation propensity, a diverse set of point mutations in the hnRNPA2B1 prion-like domain.

  16. We concluded that hnRNPA2B1 promotes the tumorigenic potential of breast cancer cells, MCF-7 and MDA-MB-231, through the extracellular-signal-regulated kinase 1/2 or signal transducer and activator of transcription 3 pathway, which may serve as a target for future therapies.

  17. results demonstrate that hnRNPA2/B1 promotes tumor cell growth by activating COX-2 signaling in NSCLC cells and imply that the hnRNPA2/B1/COX-2 pathway may be a potential therapeutic target for human lung cancers.

  18. Detection of hnRNP A2/B1 expression may be useful as a biomarker for prediction of glioma progression.

  19. The results indicate both genetic and physical interactions between disease-linked RNA-binding proteinss and DNAJB6/mrj, suggesting etiologic overlap between the pathogenesis of adult-onset inherited myopathies initiated by mutations in hnRNPA2B1 and DNAJB6.

  20. hnRNPA2B1, hnRNPD, hnRNPL , and YBX1 might play important roles in gastric cancer tumorigenesis.

Mouse (Murine) Heterogeneous Nuclear Ribonucleoprotein A2/B1 (HNRNPA2B1) interaction partners

  1. HnRNP A2/B1 loss results in alternative splicing (AS), including skipping of an exon in amyotrophic lateral sclerosis (ALS)-associated D-amino acid oxidase (DAO) that reduces D-serine metabolism.

  2. A1 and A2/B1, which are required for transcript degradation

  3. Findings suggest that hnRNP A2/B1 has an important role in regulation of the innate immune system, especially at the level of monocyte/macrophage activation.

  4. hnRNPA2/B1 plays a functional role in SMC differentiation from stem cells in vitro and embryonic branchial arch artery development.

  5. splicing repressors hnRNP A1 and A2, as well as the polypyrimidine-tract-binding protein PTB, contribute to control of pyruvate kinase isoform M1 and M2 expression

  6. overproduction of TNF-alpha leads to aberrant expression of hnRNP-A2 in the rheumatoid joint and subsequently to autoimmune reactions, which may enhance the inflammatory and destructive process.

  7. These results are consistent with a model where hnRNP E1 recruited to A2RE RNA granules by binding to hnRNP A2 inhibits translation of A2RE RNA during granule transport.

  8. Active Fyn phosphorylates hnRNP A2 and stimulates translation of an myelin basic protein (MBP) A2RE (A2 response element) -containing reporter construct.

  9. A common mechanism of mitochondrial respiratory stress-induced activation of nuclear target genes that involves hnRNP A2 as a transcription coactivator, is described.

HNRNPA2B1 Antigen Profile

Protein Summary

This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. This gene has been described to generate two alternatively spliced transcript variants which encode different isoforms.

Gene names and symbols associated with HNRNPA2B1

  • heterogeneous nuclear ribonucleoprotein A2/B1 (HNRNPA2B1) antibody
  • heterogeneous nuclear ribonucleoprotein A2/B1 S homeolog (hnrnpa2b1.S) antibody
  • heterogeneous nuclear ribonucleoprotein A2/B1 (hnrnpa2b1) antibody
  • heterogeneous nuclear ribonucleoprotein A2/B1 (Hnrnpa2b1) antibody
  • heterogeneous nuclear ribonucleoproteins A2/B1 (LOC100353281) antibody
  • 9130414A06Rik antibody
  • hnRNP antibody
  • hnrnp-A antibody
  • hnrnpa2 antibody
  • HNRNPA2B1 antibody
  • hnrnpb1 antibody
  • Hnrpa2 antibody
  • Hnrpa2b1 antibody
  • hnrpb1 antibody
  • MGC53135 antibody
  • rnpa2 antibody
  • snrpb1 antibody

Protein level used designations for HNRNPA2B1

heterogeneous nuclear ribonucleoproteins A2/B1 , hnRNP A2 / hnRNP B1 , nuclear ribonucleoprotein particle A2 protein , heterogeneous nuclear ribonucleoprotein A2/B1 , Heterogeneous nuclear ribonucleoprotein A2 homolog 1 , heterogenous nuclear ribonucleoprotein A2/B1 , hnRNP A2/B1 , heterogeneous nuclear ribonucleoprotein A2 , heterogeneous nuclear ribonucleoprotein B0a , heterogeneous nuclear ribonucleoprotein B0b , heterogeneous nuclear ribonucleoprotein B1

GENE ID SPECIES
3181 Homo sapiens
380082 Xenopus laevis
420627 Gallus gallus
463299 Pan troglodytes
475260 Canis lupus familiaris
549680 Xenopus (Silurana) tropicalis
701821 Macaca mulatta
100561250 Anolis carolinensis
100583405 Nomascus leucogenys
53379 Mus musculus
362361 Rattus norvegicus
100521762 Sus scrofa
507564 Bos taurus
100715127 Cavia porcellus
101107187 Ovis aries
100353281 Oryctolagus cuniculus
100068539 Equus caballus
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