Heterogeneous Nuclear Ribonucleoprotein A2/B1 (HNRNPA2B1) ELISA Kits

HNRNPA2B1 belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). Additionally we are shipping HNRNPA2B1 Antibodies (124) and HNRNPA2B1 Proteins (10) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
HNRNPA2B1 3181 P22626
HNRNPA2B1 53379 O88569
HNRNPA2B1 362361 A7VJC2
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Top HNRNPA2B1 ELISA Kits at antibodies-online.com

Showing 10 out of 51 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Delivery Price Details
Human 0.31 ng/mL 1.25-80 ng/mL Typical standard curve 96 Tests 13 to 16 Days
$1,026.67
Details
Pig 0.094 ng/mL 0.156-10 ng/mL   96 Tests 12 to 14 Days
$715.00
Details
Guinea Pig 37.5 pg/mL 62.5-4000 pg/mL   96 Tests 12 to 14 Days
$715.00
Details
Rabbit 37.5 pg/mL 62.5-4000 pg/mL   96 Tests 12 to 14 Days
$715.00
Details
Chicken 0.094 ng/mL 0.156-10 ng/mL   96 Tests 12 to 14 Days
$715.00
Details
Monkey 0.094 ng/mL 0.156-10 ng/mL   96 Tests 12 to 14 Days
$715.00
Details
Mouse
  96 Tests 15 to 18 Days
$707.14
Details
Rat
  96 Tests 15 to 18 Days
$707.14
Details
Dog 1.0 ng/mL 2.5-50 ng/mL   96 Tests 15 to 18 Days
$707.14
Details
Sheep
  96 Tests 15 to 18 Days
$707.14
Details

Top referenced HNRNPA2B1 ELISA Kits

  1. Human HNRNPA2B1 ELISA Kit for Sandwich ELISA - ABIN857302 : Jiao, Fan, Cai, Pan, Yan, Dong, Zong, Gan, Xiao: Analysis of Characteristics Similar to Autoimmune Disease in Keloid Patients. in Aesthetic plastic surgery 2016 (PubMed)

  2. Rat (Rattus) HNRNPA2B1 ELISA Kit - ABIN1136585 : Zhang, Huang, Hu, Sheng, Zhao, Luo: Omentum-wrapped scaffold with longitudinally oriented micro-channels promotes axonal regeneration and motor functional recovery in rats. in PLoS ONE 2012 (PubMed)

  3. Human HNRNPA2B1 ELISA Kit for Sandwich ELISA - ABIN416755 : Dowling, Pollard, Larkin, Henry, Meleady, Gately, OByrne, Barr, Lynch, Ballot, Crown, Moriarty, OBrien, Morgan, Clynes: Abnormal levels of heterogeneous nuclear ribonucleoprotein A2B1 (hnRNPA2B1) in tumour tissue and blood samples from patients diagnosed with lung cancer. in Molecular bioSystems 2014 (PubMed)

More ELISA Kits for HNRNPA2B1 Interaction Partners

Human Heterogeneous Nuclear Ribonucleoprotein A2/B1 (HNRNPA2B1) interaction partners

  1. Both low expressions of hnRNP E1 and abnormal expression of HPV16 E2 and E6 could increase the risk of high-grade CIN and cervical cancer. It seemed that they might have an important synergistic effect on the progression of cervical cancer.

  2. Study found that HNRNPA2B1 could be recruited to the 5'UTR of Sp1 mRNA regulating its expression as well as of hnRNPA2B1. Further data indicated that lung cancer patients with higher levels of Sp1 and Nm23-H1 also exhibited high levels of hnRNPA2/B1, suggesting a positive correlation between the levels of Sp1, Nm23-H1 and hnRNPA2B1 during lung cancer formation.

  3. Study demonstrated that dysfunctional mitochondria activate hnRNPA2 which in turn acetylates telomeric histones at H4K8. Using loss and gain-of-function studies also demonstrated that H4K8 acetylation is a signal for telomere shortening in response to mitochondrial stress.

  4. Arginine methylation reduces hnRNPA2 phase separation, disrupting arginine-mediated contacts. These results highlight the mechanistic role of specific LC domain interactions and modifications conserved across many hnRNP family members but altered by aggregation-causing pathological mutations.

  5. Moreover, SRSF10, hnRNP A1/A2 and Sam68 collaborate to drive the DNA damage-induced splicing response of several transcripts that produce components implicated in apoptosis, cell-cycle control and DNA repair.

  6. High HNRNPA2B1 expression is associated with cervical cancer.

  7. m6A switches may account for the previously seen enhanced hnRNP A2/B1 binding adjacent to m6A; instead of direct binding to m6A, m6A may promote accessibility of hnRNP A2/B1 to certain binding sites, thereby explaining how m6A can facilitate the ability of hnRNP A2/B1 to enhance nuclear events such as pri-miRNA processing

  8. revealed a novel heterozygous missense mutation of hnRNPA2B1 gene (c.929C>T, p. P310L) in the two patients which was then verified in all affected individuals

  9. Cilostazol pretreatment can reduce the excessive expression of inflammatory cytokines and chemokines and hnRNP A2/B1 by the Behcet's disease-related stimulants.

  10. UCP2 stimulates hnRNPA2/B1, GLUT1 and PKM2 expression and sensitizes pancreatic cancer cells to glycolysis inhibition.

  11. We demonstrate that the wild-type sequence harbors an hnRNP A1 and hnRNP A2/B1-binding exonic splicing silencer (ESS) overlapping the 5'splice site (5'ss) that prevents pseudoexon inclusion.we demonstrate that splice switching oligonucleotide (SSO) mediated blocking of the pseudoexon 3'ss and 5'ss effectively restores normal GLA splicing

  12. Data suggest that galectin-3 and heterogeneous ribonucleoprotein particle component hnRNPA2B1 interact as members of the early splicing machinery.

  13. effect of mutations on the aggregation propensity of hnRNPA2

  14. ALS-associated hnRNPA2B1 D290V mutant patient fibroblasts and motor neurons differentiated from iPSCs (iPSC-MNs) demonstrate abnormal splicing changes, likely due to increased nuclear-insoluble hnRNPA2B1. Mutant iPSC-MNs display decreased survival in long-term culture and exhibit hnRNPA2B1 localization to cytoplasmic granules as well as exacerbated changes in gene expression and splicing upon cellular stress.

  15. Motor-neuron disease (MND)-linked RNA-binding proteins (RBPs), TDP-43, FUS, and hnRNPA2B1, bind to and induce structural alteration of UGGAAexp. These RBPs suppress UGGAAexp-mediated toxicity in Drosophila by functioning as RNA chaperones for proper UGGAAexp folding and regulation of pentapeptide repeat translation.

  16. To examine the relationship between amino acid sequence and aggregation propensity, a diverse set of point mutations in the hnRNPA2B1 prion-like domain.

  17. We concluded that hnRNPA2B1 promotes the tumorigenic potential of breast cancer cells, MCF-7 and MDA-MB-231, through the extracellular-signal-regulated kinase 1/2 or signal transducer and activator of transcription 3 pathway, which may serve as a target for future therapies.

  18. results demonstrate that hnRNPA2/B1 promotes tumor cell growth by activating COX-2 signaling in NSCLC cells and imply that the hnRNPA2/B1/COX-2 pathway may be a potential therapeutic target for human lung cancers.

  19. Detection of hnRNP A2/B1 expression may be useful as a biomarker for prediction of glioma progression.

  20. The results indicate both genetic and physical interactions between disease-linked RNA-binding proteinss and DNAJB6/mrj, suggesting etiologic overlap between the pathogenesis of adult-onset inherited myopathies initiated by mutations in hnRNPA2B1 and DNAJB6.

Mouse (Murine) Heterogeneous Nuclear Ribonucleoprotein A2/B1 (HNRNPA2B1) interaction partners

  1. HnRNP A2/B1 loss results in alternative splicing (AS), including skipping of an exon in amyotrophic lateral sclerosis (ALS)-associated D-amino acid oxidase (DAO) that reduces D-serine metabolism.

  2. A1 and A2/B1, which are required for transcript degradation

  3. Findings suggest that hnRNP A2/B1 has an important role in regulation of the innate immune system, especially at the level of monocyte/macrophage activation.

  4. hnRNPA2/B1 plays a functional role in SMC differentiation from stem cells in vitro and embryonic branchial arch artery development.

  5. splicing repressors hnRNP A1 and A2, as well as the polypyrimidine-tract-binding protein PTB, contribute to control of pyruvate kinase isoform M1 and M2 expression

  6. overproduction of TNF-alpha leads to aberrant expression of hnRNP-A2 in the rheumatoid joint and subsequently to autoimmune reactions, which may enhance the inflammatory and destructive process.

  7. These results are consistent with a model where hnRNP E1 recruited to A2RE RNA granules by binding to hnRNP A2 inhibits translation of A2RE RNA during granule transport.

  8. Active Fyn phosphorylates hnRNP A2 and stimulates translation of an myelin basic protein (MBP) A2RE (A2 response element) -containing reporter construct.

  9. A common mechanism of mitochondrial respiratory stress-induced activation of nuclear target genes that involves hnRNP A2 as a transcription coactivator, is described.

HNRNPA2B1 Antigen Profile

Antigen Summary

This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. This gene has been described to generate two alternatively spliced transcript variants which encode different isoforms.

Gene names and symbols associated with HNRNPA2B1

  • heterogeneous nuclear ribonucleoprotein A2/B1 (HNRNPA2B1) antibody
  • heterogeneous nuclear ribonucleoprotein A2/B1 S homeolog (hnrnpa2b1.S) antibody
  • heterogeneous nuclear ribonucleoprotein A2/B1 (hnrnpa2b1) antibody
  • heterogeneous nuclear ribonucleoprotein A2/B1 (Hnrnpa2b1) antibody
  • heterogeneous nuclear ribonucleoproteins A2/B1 (LOC100353281) antibody
  • 9130414A06Rik antibody
  • hnRNP antibody
  • hnrnp-A antibody
  • hnrnpa2 antibody
  • HNRNPA2B1 antibody
  • hnrnpb1 antibody
  • Hnrpa2 antibody
  • Hnrpa2b1 antibody
  • hnrpb1 antibody
  • MGC53135 antibody
  • rnpa2 antibody
  • snrpb1 antibody

Protein level used designations for HNRNPA2B1

heterogeneous nuclear ribonucleoproteins A2/B1 , hnRNP A2 / hnRNP B1 , nuclear ribonucleoprotein particle A2 protein , heterogeneous nuclear ribonucleoprotein A2/B1 , Heterogeneous nuclear ribonucleoprotein A2 homolog 1 , heterogenous nuclear ribonucleoprotein A2/B1 , hnRNP A2/B1 , heterogeneous nuclear ribonucleoprotein A2 , heterogeneous nuclear ribonucleoprotein B0a , heterogeneous nuclear ribonucleoprotein B0b , heterogeneous nuclear ribonucleoprotein B1

GENE ID SPECIES
3181 Homo sapiens
380082 Xenopus laevis
420627 Gallus gallus
463299 Pan troglodytes
475260 Canis lupus familiaris
549680 Xenopus (Silurana) tropicalis
701821 Macaca mulatta
100561250 Anolis carolinensis
100583405 Nomascus leucogenys
53379 Mus musculus
362361 Rattus norvegicus
100521762 Sus scrofa
507564 Bos taurus
100715127 Cavia porcellus
101107187 Ovis aries
100353281 Oryctolagus cuniculus
100068539 Equus caballus
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